2016
Is Radiotherapy Warranted Following Intrahepatic Cholangiocarcinoma Resection? The Impact of Surgical Margins and Lymph Node Status on Survival
Hammad A, Berger N, Eastwood D, Tsai S, Turaga K, Christian K, Johnston F, Pawlik T, Gamblin T. Is Radiotherapy Warranted Following Intrahepatic Cholangiocarcinoma Resection? The Impact of Surgical Margins and Lymph Node Status on Survival. Annals Of Surgical Oncology 2016, 23: 912-920. PMID: 27654107, DOI: 10.1245/s10434-016-5560-1.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedBile Duct NeoplasmsBile Ducts, IntrahepaticCholangiocarcinomaComorbidityDatabases, FactualFemaleHumansLymphatic MetastasisMaleMargins of ExcisionMiddle AgedNeoplasm GradingNeoplasm StagingNeoplasm, ResidualPropensity ScoreRadiotherapy, AdjuvantRetrospective StudiesSurvival RateConceptsPositive resection marginsLymph node statusResection marginsPredictors of survivalIntrahepatic cholangiocarcinoma resectionIntrahepatic cholangiocarcinomaPropensity score matchingNode statusT stageSurvival outcomesImpact of surgical marginsLymph node negative patientsSurgically resected intrahepatic cholangiocarcinomaNegative predictors of survivalReceipt of RTNegative resection marginsNode negative patientsImpact of radiotherapyNational Cancer DatabaseNode negative diseaseResected intrahepatic cholangiocarcinomaImprove survival outcomesTumor T stageEarly-stage diseaseIntrahepatic cholangiocarcinoma patientsRadiotherapy for intrahepatic cholangiocarcinoma: An analysis of the National Cancer Database.
Hammad A, Younan G, Rajeev R, Berger N, Turaga K, Johnston F, Christians K, Gamblin T. Radiotherapy for intrahepatic cholangiocarcinoma: An analysis of the National Cancer Database. Journal Of Clinical Oncology 2016, 34: 379-379. DOI: 10.1200/jco.2016.34.4_suppl.379.Peer-Reviewed Original ResearchPositive resection marginsPredictors of survivalNational Cancer DatabaseResection marginsIntrahepatic cholangiocarcinomaSurgical resectionCancer DatabaseSurgically resected intrahepatic cholangiocarcinomaNegative predictors of survivalPositive predictor of survivalReceipt of RTResection margin statusImpact of radiotherapyResected intrahepatic cholangiocarcinomaKaplan-Meier methodR0 statusNegative marginsLiver resectionImproved survivalRadiotherapyMargin statusResectionMultivariate regression modelFemale sexImpact survival
2010
Histopathologic Basis for the Favorable Survival after Resection of Intraductal Papillary Mucinous Neoplasm-Associated Invasive Adenocarcinoma of the Pancreas
Poultsides GA, Reddy S, Cameron JL, Hruban RH, Pawlik TM, Ahuja N, Jain A, Edil BH, Iacobuzio-Donahue CA, Schulick RD, Wolfgang CL. Histopathologic Basis for the Favorable Survival after Resection of Intraductal Papillary Mucinous Neoplasm-Associated Invasive Adenocarcinoma of the Pancreas. Annals Of Surgery 2010, 251: 470-476. PMID: 20142731, PMCID: PMC3437748, DOI: 10.1097/sla.0b013e3181cf8a19.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmPancreatic ductal adenocarcinomaResection of IPMNsAdverse pathologic characteristicsInvasive pancreatic adenocarcinomaAdvanced T stageLymph node metastasisInvasive adenocarcinomaPancreatic adenocarcinomaFavorable survivalNode metastasisPathologic characteristicsT stageVascular invasionRegional lymph node metastasisFavorable biologic behaviorMicroscopic margin involvementPancreatic resection databasePositive resection marginsCox regression analysisHigh tumor gradePapillary mucinous neoplasmPoor tumor differentiationCurative intentMargin involvement
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