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    Andrew Wang, MD/PhD, AB

    Associate Professor of Internal Medicine (Rheumatology)
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    Associate Professor of Internal Medicine (Rheumatology)

    Biography

    I obtained my AB from Harvard University and my MD, PhD degrees in 2011 from University of Texas Southwestern with additional training done at the University of Paris. As a part of his MD/PhD training in the laboratories of Drs. Edward Wakeland and Chandra Mohan, I identified a key role for the CXCR4/SDF-1 axis in end-organ targeting (in mouse and man), an important insight in the pathogenesis of SLE. I then did my Internal Medicine internship and residency training at Yale and joined the ABIM Short Track Pathway into the Rheumatology fellowship.

    I joined the laboratory of Dr. Ruslan Medzhitov in July 2014 for my postdoctoral training. There, based on my clinical experience as a house officer, I shifted my focus to understanding how inflammation and metabolism are coordinated on an organismal level. My work in Dr. Medzhitov's laboratory led to the discovery that different inflammatory states are coordinated with different metabolic programs, an important insight into the pathogenesis of many inflammatory diseases. I joined the faculty as Assistant Professor in Internal Medicine (Rheumatology) in August 2017 and the Immunobiology faculty in July 2019.

    My lab is generally interested in trying to understand how the environment interacts with the host to affect disease trajectories. We utilize a broad range of techniques spanning disciplines spanning physiology, metabolism, inflammation, neurobiology, and immunology coupled with patient samples.

    On-going interests:

    1. Identifying and dissecting environmental determinants of inflammatory diseases.

    2. Understanding inflammatory physiology

    3. Understanding placebo and nocebo physiology.

    4. Understanding the "moonlighting" functions of the immune system.

    5. Understanding energy allocation in host defense. (Collaboration with Dr. Rachel Perry)

    6. Understanding the relationship between cell death and inflammation. (Collaboration with Dr. Aaron Ring)


    In the clinic, I see patients with inflammatory conditions, many of the times with no clear diagnosis, as well as patients with rheumatologic diseases.

    Appointments

    Other Departments & Organizations

    Education & Training

    ABIM Research Pathway Fellow
    Yale University School of Medicine (2017)
    Post-doctoral Fellow
    Yale University School of Medicine (2017)
    ABIM Research Pathway Resident
    Yale University School of Medicine/Yale New Haven Hospital (2013)
    MD/PhD
    University of Paris V, Immunobiology (2011)
    MD/PhD
    University of Texas Southwestern Medical School, Immunobiology (2011)
    AB
    Harvard University, Biochemistry (2004)

    Research

    Overview

    Abbreviated publications (chronologic):

    Wang A, Fairhurst AM, Tus K, Subramanian S, Liu Y, Lin F, Igarashi P, Zhou XJ, Batteux F, Wong D, Wakeland EK, Mohan C. CXCR4/CXCL12 hyperexpression plays a pivotal role in the pathogenesis of lupus. J Immunol. 2009 Apr 1; 182(7): 4448-58.

    Wang A, Guilpain P, Chong BF, Chouzenoux S, Guillevin L, Du Y, Zhou XJ, Lin F, Fairhurst AM, Boudreaux C, Roux C, Wakeland EK, Davis LS, Batteux F, Mohan C. Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus. Arthritis Rheum. 2010 Nov; 62(11): 3436-46.

    Wang A, Huen SC, Luan HH, Yu S, Zhang C, Gallezot JD, Booth CJ, Medzhitov R. Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation. Cell. 2016 Sep 8; 166(6): 1512-1525

    Wang A, Huen SC, Luan HH, Baker K, Rinder H, Booth CJ, Medhzitov R. Glucose metabolism mediates disease tolerance in cerebral malaria. PNAS. 2018 Oct 23;115(43):11042-11047.

    Wang A, Luan HH, Medzhitov R. An evolutionary perspective on immunometabolism. Science. 2019 Jan 11;363(6423)

    Wang A*, Pope S, Weinstein J, Yu S, Zhang C, Booth CJ, Medzhitov R*. Specific Sequences of Infectious Challenge Leads to Secondary Hemophagocytic Lymphohistiocytosis-like Disease in Mice. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2200-2209. * Co-corresponding

    Wang A*, Medzhitov R*. Counting Calories: The Cost of Inflammation. Cell 2019 Apr 4;177(2):223-224. *Co-corresponding

    Wang A*, Medzhitov R*. Not the usual suspect: type I interferon-responsive T cells drive infection-induced cachexia. Nat Immunol. 2019 Jun;20(6):666-667. *Co-corresponding

    Wang A*, Luan HH, Hilliard B, Carvalho F, Rosen C, Ahasic A, Herzog E, Kang I, Pisani M, Yu S, Zhang C, Ring A, Young L, Medzhitov R*. GDF15 is an Inflammation-Induced Central Mediator of Tissue Tolerance. Cell. 2019. Aug 22;178(5):1231-1244.e11.

    Uchendu SN, Wang A* . Less Pain, More Gain: Should Placebo Be a Clinical Therapeutic? Arthritis Rheumatol. 2020. Apr;72(4):511-514.

    Qing H, Desrouleaux R, Israni-Winger K, Fogelman N, Zhang C, Rashad S, Palm NW, Sinha R, Piccioto MR, Perry RJ, Wang A* . Origin and function of stress-induced IL6 in murine models. Cell. 2020. Jun 27;S0092-8674(20)30687-5.

    Medical Research Interests

    Inflammation; Metabolism; Neuroimmunomodulation; Psychoneuroimmunology

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Andrew Wang's published research.

    Publications

    2024

    2023

    2022

    2021

    2020

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    Clinical Trials

    Current Trials

    Academic Achievements & Community Involvement

    • honor

      Pew Biomedical Scholar

      National Award
    • honor

      Blavatnik Fund for Innovation Awardee

      Yale School of Medicine Award
    • honor

      Martin Luther King Service Award

      Other Award
    • honor

      Solomon Snyder Scholar

      International AwardAcademy of Achievement

    Clinical Care

    Overview

    I obtained my AB from Harvard University and my MD, PhD degrees in 2011 from University of Texas Southwestern with additional training done at the University of Paris. As a part of his MD/PhD training in the laboratories of Drs. Edward Wakeland and Chandra Mohan, I identified a key role for the CXCR4/SDF-1 axis in end-organ targeting (in mouse and man), an important insight in the pathogenesis of SLE. I then did my Internal Medicine internship and residency training at Yale and joined the ABIM Short Track Pathway into Rheumatology fellowship. I joined the laboratory of Dr. Ruslan Medzhitov in July 2014 for my postdoctoral training. There, based on my clinical experience as a house officer, I shifted my focus to understanding how inflammation and metabolism are coordinated on an organismal level. My work in Dr. Medzhitov's laboratory led to the discovery that different inflammatory states are coordinated with different metabolic programs, an important insight into the pathogenesis of many inflammatory diseases. I joined the faculty as Assistant Professor in Internal Medicine (Rheumatology) in August 2017 and joined the Immunobiology faculty in July 2019.

    My lab broadly studies metabolism and inflammation in order to understand pathways in inflammatory physiology that can be therapeutically targeted to treat diseases ranging from sepsis and autoimmunity to psychiatric diseases like depression. We use mouse models, cell culture, and human samples and apply techniques spanning the disciplines of metabolism, immunobiology, and behavioral biology.

    Clinical Specialties

    Rheumatology

    Fact Sheets

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    Board Certifications

    • Rheumatology

      Certification Organization
      AB of Internal Medicine
      Original Certification Date
      2017

    • Internal Medicine

      Certification Organization
      AB of Internal Medicine
      Original Certification Date
      2017

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    Contacts

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    Locations

    • S520

      Lab

      The Anlyan Center

      300 Cedar Street

      New Haven, CT 06519

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    • Yale Rheumatology, Allergy & Immunology

      Academic Office

      The Anlyan Center

      300 Cedar Street, Fl 5th, Rm S-513

      New Haven, CT 06519

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