Dr. Carrie L. Lucas received her PhD from Harvard Medical School and her postdoctoral training from the National Institutes of Health, NIAID. Her laboratory discovers single-gene defects underlying severe immune disorders in humans and dissects new biology and mechanisms revealed by these gene mutations using patient cells and genetically engineered mouse models.
Robert I. Levy Professor of Medicine (Cardiovascular Medicine) and Professor of Immunobiology; Associate Chief, Cardiovascular Medicine, Internal Medicine; Senior Vice Chief for Academic Development, Cardiovascular Medicine
Anthony N. Brady Professor of Dermatology, Pathology and Immunobiology; Director, Yale SPORE in Skin Cancer; Director, Yale Center for Immuno-Oncology; Co-Leader, Cancer Immunology, Yale Cancer Center
Marcus Bosenberg MD, PhD, is a physician scientist who directs a leading melanoma research laboratory, is Co-Leader of the Cancer Immunology Program of Yale Cancer Center, Director of the Yale Center for Immuno-Oncology, Contact PI of the Yale SPORE in Skin Cancer, Director of the Center for Precision Cancer Modeling, and is a practicing dermatopathologist at Yale Dermatopathology through Yale Medicine.In his research, Dr. Bosenberg studies factors that regulate anti-cancer immune responses. His laboratory has developed several widely utilized mouse models in order to study how melanoma forms and progresses, to test new cancer therapies, and how the immune system can be stimulated to fight cancer. He works to translate basic scientific findings into improvements in cancer diagnosis and therapy. He has published over 200 peer-reviewed articles and is a...
Assistant Professor of Medicine (Medical Oncology), Louis Goodman and Alfred Gilman Yale Scholar
David Braun, MD, PhD, is an Assistant Professor of Medicine (Medical Oncology) and a member of the Center of Molecular and Cellular Oncology (CMCO) at Yale Cancer Center. Dr. Braun cares for patients with kidney cancers. He received his PhD in Computational Biology from the Courant Institute of Mathematical Science at New York University and his medical degree from Icahn School of Medicine at Mount Sinai. He completed his residency at the Brigham and Women’s Hospital where he received the Dunn Medical Intern Award and served as Chief Medical Resident before completing fellowship training in adult oncology through the Dana-Farber/Partners CancerCare program where he was appointed the Emil Frei Fellow and the John R. Svenson Fellow. Dr. Braun joined Yale from Dana-Farber Cancer Institute where he was an Instructor in Medicine with clinical and scientific interest in...
Dr. Caron is a Canadian scientist with a background in Biotechnology and Systems Immunology. He received his PhD from the University of Montreal in Canada under the guidance of Dr. Claude Perreault and completed his education at ETH-Zürich in Switzerland under the guidance of Dr. Ruedi Aebersold. Dr. Caron is known for his international leadership and expertise in immunopeptidomics for the global analysis of MHC-associated peptides using mass spectrometry technologies. His scientific program has the potential to revolutionize the research on vaccine design, cancer immunotherapy, infectious and autoimmune diseases, including treatment of neurodegenerative diseases and aging. Dr. Caron began his career as a Principal Investigator in 2018 at the University of Montreal, Canada. In 2023, Dr. Caron was recruited by the Yale Center for Immuno-Oncology (YCIO) and the...
Grace Chen received her undergraduate training in the College of Chemistry at UC Berkeley. She attended Harvard University for her PhD where she worked in David Liu's laboratory to discover and characterize novel RNA modifications. Her postdoctoral research was at Stanford University in Howard Chang's group, where she investigated circular RNA immunity. Grace joined Yale University as a faculty in the Department of Immunobiology in 2019. Her research focuses on the functions and regulations of circular RNAs and RNA modifications in health and disease.
United Technologies Corporation Professor in Cancer Research and Professor of Immunobiology, of Dermatology and of Medicine (Medical Oncology)
Dr. Lieping Chen is an immunologist interested in basic T cell biology, cancer immunology, and translational research to develop new treatments for human diseases including cancer. Prior to joining Yale, he was a faculty member at Johns Hopkins University School of Medicine and Mayo Clinic, and a scientist in Bristol-Myers Squibb Pharmaceutical Research Institute. Dr. Chen has published over 400 peer-reviewed research articles. His work in the discovery of the PD-1/PD-L1 pathway for cancer immunotherapy was cited as the #1 breakthrough of the year by Science magazine in 2013. He is a member of the National Academy of Sciences and a fellow of the American Association for Cancer Research.
Associate Professor of Genetics and of Neurosurgery
Sidi Chen joined the Yale Faculty in 2015 in the Department of Genetics, Systems Biology Institute, and Yale Cancer Center. His research focuses on providing a global understanding of biological systems and development of novel breakthrough therapeutics. Chen developed and applied genome editing and high-throughput screening technologies, precision CRISPR-based in vivo models of cancer, global mapping of functional drivers of cancer oncogenesis and metastasis. He is leading a research group to seek global understandings of the molecular and cellular factors controlling disease progression and immunity. His group continuously invents versatile systems that enable rapid identification of novel targets and development of new modalities of cancer immunotherapy, cell therapy and gene therapy. His goal is to uncover novel insights in cancer and various other immunological...
Paul B. Beeson Professor of Medicine (Rheumatology) and Professor of Immunobiology; Paul B. Beeson Professor of Medicine, Internal Medicine: Rheumatology; Program Director, Investigative Medicine, Internal Medicine: Rheumatology
Dr. Craft is an AOA graduate of the University of North Carolina School of Medicine. He did medical and immunology training at Yale and is currently Paul B. Beeson Professor of Medicine and Professor of Immunobiology. He directs a laboratory devoted to understanding of host responses to pathogen challenge and to autoimmunity. His lab was among the 4 that simultaneously dissected the transcriptional regulation of T follicular helper cells, a finding listed among the most significant milestone discoveries in T cell development by the journal Nature and has made sentinel discoveries defining targets of the immune response in lupus and the role of T cells in driving pathogenic autoantibody and mechanisms of T cell mediate tissue damage in that disease. He has trained over 40 postdoctoral fellows and 26 PhD and MD/PhD graduate students including those currently in his lab. He is director of...
Waldemar Von Zedtwitz Professor of Pathology and Professor of Immunobiology; Director, Yale Center for Research on Aging (Y-Age), Pathology
Son of teachers, Deep grew up in Hisar (Northwest India). He studied Veterinary Medicine in India, did PhD Research in University of Hannover Germany and postdoc research in Morehouse School of Medicine and NIH. He currently holds Waldemar Von Zedtwitz endowed chair and is a Professor in the Departments of Pathology, Comparative Medicine and Immunobiology. Dixit is also the director of Yale Center for Research on Aging (Y-Age). Dixit lab studies Immunometabolism and aging. His team help establish NLRP3 inflammasome in causing ‘inflammaging’ and immunosenescence that leads to age-related chronic diseases including metabolic dysfunction. Dixit and his collaborators have identified that switch from glycolysis to ketogenesis deactivates the inflammasome and reduces immunopathology. The ongoing work in his laboratory on caloric restriction (CR) in humans (CALERIE-II...
Emilia Favuzzi is an Assistant Professor in the Department of Neuroscience and Wu Tsai Institute at Yale University. She grew up in Italy and received a B.S. in Biology and a M.S. in Neurobiology from Sapienza University of Rome. She did her doctoral training at the Institute of Neuroscience in Alicante (Spain) and the Centre for Developmental Neurobiology at King’s College London. Her graduate research focused on the cellular and molecular mechanisms of inhibitory circuit development and plasticity in the cerebral cortex. In her postdoctoral work at Harvard Medical School and the Broad Institute, she focused on microglia-inhibitory synapse interactions during development and discovered that specialized microglia differentially engage with specific synapse types. Her past work opened a new avenue in understanding neuroimmune crosstalk by showing that neuroimmune interactions...
Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and Professor of Epidemiology (Microbial Diseases) and of Microbial Pathogenesis; Affiliated Faculty, Yale Institute for Global Health; Section Chief, Infectious Diseases, Internal Medicine
My laboratory investigates vector-borne diseases. Studies are directed toward understanding Lyme disease, flaviviral infections including dengue and West Nile viruses, and malaria. Efforts on Lyme disease include exploring immunity to Borrelia burgdorferi, selective B. burgdorferi gene expression in vivo, and the immunobiology of Lyme arthritis. Flaviviruses and Plasmodium are used as models to understand the molecular interactions between pathogens, their arthropod vectors and their mammalian hosts. Finally, we are developing new approaches to prevent ticks and mosquitoes from feeding on a vertebrate host, thereby interfering with pathogen transmission.
Sterling Professor of Immunobiology; Investigator, Howard Hughes Medical Institute
Dr. Flavell is Sterling Professor of Immunobiology at Yale University School of Medicine, and an Investigator of the Howard Hughes Medical Institute. He received his B.Sc. (Honors) in 1967 and Ph.D. in 1970 in biochemistry from the University of Hull, England, and performed postdoctoral work in Amsterdam (1970-72) with Piet Borst and in Zurich (1972-73) with Charles Weissmann. Before accepting his current position in 1988, Dr. Flavell was first Assistant Professor (equivalent) at the University of Amsterdam (1974-79); then Head of the Laboratory of Gene Structure and Expression at the National Institute for Medical Research, Mill Hill, London (1979-82); and subsequently President and Chief Scientific Officer of Biogen Research Corporation, Cambridge, Massachusetts (1982-88). Dr. Flavell is a fellow of the Royal Society, a member of the National Academy of Sciences as well...
Associate Professor of Laboratory Medicine and Immunobiology
Dr. Ellen Foxman, M.D., PhD. is an Associate Professor of Laboratory Medicine and Immunobiology at the Yale School of Medicine. Her laboratory studies antiviral defense in the human respiratory tract, focusing on innate immunity, an inborn system of protective mechanisms that guards against harmful viruses or bacteria, even when the body has never encountered the infection before. The overarching goal of this research is to improve the diagnosis, treatment, and prevention of illnesses caused by respiratory viruses.Background. Dr. Foxman trained in medicine and immunology at Stanford University. She became interested in respiratory viruses during her residency training in clinical pathology at Harvard's Brigham and Women's Hospital, due to the advances in testing that were beginning to reveal a previously unappreciated very high prevalence of these viruses. She later joined Dr....
Assistant Professor of Medicine (Infectious Diseases)
Dr. Benjamin Goldman-Israelow is an Assistant Professor in the Department of Internal Medicine in the section of Infectious Diseases. He obtained his AB in Biology from Washington University in St. Louis and his MD and PhD degrees from The Icahn School of Medicine at Mount Sinai. He joined Yale internal medicine in the ABIM Short Track Pathway, completing residency and Infectious Diseases fellowship training. During fellowship, Dr. Goldman-Israelow joined the laboratory of Dr. Akiko Iwasaki for his postdoctoral studies. There, he has studied SARS-CoV-2 infection, pathogenesis, and immunity in both patients and pre-clinical models. His work has led to the development of one of the first mouse models to study SARS-CoV-2, the identification of immunologic factors contributing to COVID-19 pathogenesis and protection, and the development of a novel mucosal vaccine strategy that protects...
C.N.H. Long Professor of Microbial Pathogenesis and Director of Microbial Sciences Institute; Chair, Microbial Pathogenesis
Andrew L. Goodman, PhD, is the C. N. H. Long Professor and Chair of the Department of Microbial Pathogenesis and Director of the Yale Microbial Sciences Institute. Goodman received his undergraduate degree in Ecology and Evolutionary Biology from Princeton University, his PhD in Microbiology and Molecular Genetics from Harvard University, and completed postdoctoral training at Washington University. His lab uses microbial genetics, gnotobiotics, and mass spectrometry to understand how gut microbes interact with their host during health and disease. The lab is also interested in how the microbiome impacts the efficacy and toxicity of medical drugs. The lab’s contributions have been recognized by the NIH Director New Innovator Award, the Pew Foundation, the Dupont Young Professors Award, the Burroughs Wellcome Foundation, the Howard Hughes Medical Institute Faculty...
Associate Professor of Immunobiology; Director, In Vivo Imaging Facility, Yale School of Medicine; Scientific Director, Flow Cytometry Research Facility, YSM central core
William S. and Lois Stiles Edgerly Professor of Neurology and Professor of Immunobiology; Chair, Neurology; Neurologist-in-Chief, Yale New Haven Hospital
Dr. Hafler is the William S. and Lois Stiles Edgerly Professor and Chairman Department of Neurology, Yale School of Medicine and is the Neurologist-in-Chief of the Yale-New Haven Hospital. He graduated magna cum laude in 1974 from Emory University with combined B.S. and M.Sc. degrees in biochemistry, and the University of Miami School of Medicine in 1978. He then completed his internship in internal medicine at Johns Hopkins followed by a neurology residency at Cornell Medical Center-New York Hospital in New York. Dr. Hafler received training in immunology at the Rockefeller University then at Harvard where he joined the faculty in 1984. He was one of the Executive Directors of the Program in Immunology at Harvard Medical School and was on the faculty of the Harvard-MIT Health Science and Technology program where he was actively involved in the training of graduate students...
C.N.H. Long Professor of Immunobiology and of Medicine (Endocrinology)
My background and research are in translational immunology. I am interested in understanding the basis for autoimmune diseases and developing new therapies based on our understanding of disease mechanisms. My focus has largely been in the field of autoimmune Type 1 diabetes. The work encompasses basic laboratory work as well as clinical studies to understanding the regulation of autoreactive T cells to clinical trials that involve novel therapeutics. As part of these studies my lab has been very interested in analysis of beta cell function in Type 1 diabetes and identifying the cellular mechanisms that can protect them from immune killing. We have also been studying the development of autoimmune diabetes in patients with cancers who are treated with checkpoint inhibitors. Our clinical and basic studies are focused on understanding how beta cells are destroyed and react to...
I am interested on the cellular and molecular mechanisms by which innate immune cells, and their hematopoietic precursors, contribute to organismal physiology and pathology. As a postdoctoral trainee I developed and used live imaging modalities to study acute inflammatory disease and discovered the receptors that mediate early neutrophil recruitment, and the signals that cause acute vascular injury. As an independent researcher, my laboratory further developed tools to study of thrombo-inflammation and the dramatic consequences in several organs, including the lung, brain and heart. We discovered new functions for innate immune cells, and demonstrated that circadian rhythms in the bone marrow are entrained in part by neutrophils entering this organ, and that these rhythms are critical for immune defense and inflammation. I am also interested in other type of innate immune...