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INFORMATION FOR

    Medical Research Scholars Program

    The Medical Research Scholars Program (MRSP) bridges barriers between traditional predoctoral and medical training by providing you with both medically oriented coursework and a mentored clinical experience. The coursework provides a grounding in biomedicine, and the clinical experience enables you to interact with patients to learn firsthand about disease symptoms, treatment options, and the limitations of current therapies. This combination of medical knowledge and face-to-face interaction with patients and their doctors provides a new perspective and enhances the rigorous training you will receive in the BBS Program.

    Upon completing the MRSP curriculum, you will be able to work much more closely with physicians and physician-scientists and will be able to perform clinically relevant basic research.

    A grant from the Howard Hughes Medical Institute initially helped to launch the MRSP, and a Molecular Medicine Training Grant (T32GM158462) funded by the National Institute of General Medical Sciences now supports the program.

    Program Eligibility

    Only incoming BBS students are eligible to apply, and we admit 5-7 students per year into MRSP. We will invite you to apply after you accept Yale's offer of admission. If admitted, you will still remain in your BBS Track but will participate in the additional MRSP curriculum.

    The Curriculum

    The MRSP curriculum (see table below) consists of four full semester courses that focus first on normal human physiology and organ-based cell biology, followed by human pathobiology and then an introduction to drug discovery, validation, and clinical trials. You also take an intensive summer course in biostatistics. Some of these MRSP courses are open to all BBS students, at the discretion of the course directors.

    The centerpiece of the MRSP is an additional two-year Mentored Clinical Experience course during years two and three of the program. This course integrates basic and clinical research while additionally granting you access to patients and patient settings. Exposure to patients and to the practice of medicine will enable you to work more confidently at the interface of research and medicine and facilitate future collaborations with clinical researchers. The Mentored Clinical Experience is open only to students formally enrolled as Medical Research Scholars.



    Year 1

    Term Course Directors
    Fall Physiological Systems (C&MP 5500) M. Saltzman, S. Campbell
    Spring Organ Systems (CBIO 5604) A. Vignery
    Summer Intro to Biostatistics in Clinical Investigation (IMED 5645) E. Shapiro, V. Shabanova

    Year 2

    Term Course Directors

    Pathobiology-choice of #1, #2, or #3 below:
    Fall 1) Molecular Mechanisms of Human Disease (PATH 5690) D. Braddock,
    C. Fernandez-Hernando
    Fall & Spring 2) Medical Physiology Case Conference (C&MP 5600)
    E. Boulpaep
    Spring 3) Physiology in Medicine (C&MP 5700) E. Boulpaep
    Spring Topics in Human Investigation (B&BS 6680) J. Craft, K. Anderson
    Fall & Spring Mentored Clinical Experience (C&MP 5610) L. Konnikova, R. Pierce

    Year 3

    Term Course Directors
    Fall & Spring Mentored Clinical Experience (C&MP 5610) L. Konnikova, R. Pierce

    Student Selection Process

    MRSP students at the annual reception to honor those who completed the curriculum.

    The application deadline each year will be in mid-May. The MRSP core leadership team will review your MRSP application, along with your original application to the BBS Program. They will make final selections based largely on your responses on the MRSP application, as well as on your potential for managing the demands of the MRSP curriculum on top of your regular BBS requirements. If necessary, the selection committee may conduct interviews of applicants.

    MRSP Application

    Application deadline

    The next application deadline will be in May of 2026, and we will invite incoming BBS students to apply after April 15. Please direct questions related to the application process and curriculum to bbs@yale.edu.


    Program Leadership

    • Co-Director

      Professor of Cell Biology and of Molecular, Cellular and Development Biology; Co-Leader, DNA Damage and Genome Integrity, Yale Cancer Center; Associate Cancer Center Director, Basic Science

    • Professor of Pharmacology and of Molecular Biophysics and Biochemistry; Co-Leader, Developmental Therapeutics, Yale Cancer Center; Co-Director Therapeutics/Chemotherapy Program

    • Paul B. Beeson Professor of Medicine (Rheumatology) and Professor of Immunobiology; Paul B. Beeson Professor of Medicine, Internal Medicine: Rheumatology; Program Director, Investigative Medicine, Internal Medicine: Rheumatology

    • Henry J. and Joan W. Binder Professor of Medicine (Digestive Diseases) and of Cell Biology; Director Investigated Gastroenterology NIH T32, Internal Medicine; Deputy Director, MD-PhD Program

    • Associate Professor of Pediatrics (Critical Care); Associate Program Director for Pediatric Critical Care Medicine Fellowship, Pediatrics; Co-Director of the Mentored Clinical Experience, Medical Research Training Program

    • Waldemar Von Zedtwitz Professor of Microbial Pathogenesis and of Immunobiology and Director of Biological and Biomedical Sciences (BBS); Vice-Chair, Department of Microbial Pathogenesis; Co-Director of Graduate Admissions (DGA), Microbiology PhD Program of Biological and Biomedical Sciences