Epigenomics

Epigenetic mechanisms that influence gene expression, including histone modification, DNA methylation and chromatin accessibility,play critical roles in human development and disease. HGS faculty use powerful genome-wide technologies tools such as ChIP-seq, ATAC-seq, and bisulfite sequencing to map epigenetic information at the level of human tissues and single cells, and investigate how the environment, aging, and genetic context shape gene regulation and cellular identity.