Manju Prasad, MD, MBBS
Professor of PathologyCards
Additional Titles
Director, Endocrine, Head & Neck Pathology Fellowship Program, Pathology
Director, Endocrine, Head and Neck Pathology, Pathology
Contact Info
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View Doctor ProfileAdditional Titles
Director, Endocrine, Head & Neck Pathology Fellowship Program, Pathology
Director, Endocrine, Head and Neck Pathology, Pathology
Contact Info
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileAdditional Titles
Director, Endocrine, Head & Neck Pathology Fellowship Program, Pathology
Director, Endocrine, Head and Neck Pathology, Pathology
Contact Info
About
Titles
Professor of Pathology
Director, Endocrine, Head & Neck Pathology Fellowship Program, Pathology; Director, Endocrine, Head and Neck Pathology, Pathology
Biography
I am an Oncologic Surgical Pathologist by training with a life-long interest in cancers of the head and neck including salivary glands, thyroid, parathyroid and adrenal glands. Pathology is the study of the underlying mechanism of diseases which helps guide treatment individualized to each patient. I am deeply committed to teaching and extending my expertise to patients and physicians. I started the Endocrine, Head & Neck subspecialty pathology program in 2009, a program dedicated to the detection of cancer, prediction of their behavior and response to therapy, often harmful to the patients and sometimes, to their families. The program now has a complement of five surgical pathologists and an ACGME-accredited fellowship program and works in closely with molecular and cytopathology. My research includes head and neck melanomas arising in UV-light protected sites, e.g. oral and nasal mucosa, HPV-associated cancers of the head & neck, and the molecular mechanism of thyroid, parathyroid and adrenal tumors. I am also interested in public education.
Appointments
Pathology
Professor Phased RetirementPrimary
Other Departments & Organizations
Education & Training
- Fellow
- Memorial Sloan Kettering Cancer Center (2000)
- Fellow`
- Memorial Sloan Kettering Cancer Center (1999)
- Resident
- New York Presbyterian Hospital (1998)
- MD
- Institute of Medical Sciences Varanasi (1984)
- MBBS
- Institute of Medical Sciences Varanasi (1981)
Research
Overview
Medical Research Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Andrea Barbieri, MD
Catherine Dinauer, MD
Benjamin L. Judson, MD, MBA
Adebowale Adeniran, MD
Adriana Dana Oprea, MD
Amit Mahajan, MD
Publications
2024
EIF1AX mutation in thyroid nodules: a histopathologic analysis of 56 cases in the context of institutional practices
Abi-Raad R, Xu B, Gilani S, Ghossein R, Prasad M. EIF1AX mutation in thyroid nodules: a histopathologic analysis of 56 cases in the context of institutional practices. Virchows Archiv 2024, 485: 859-867. PMID: 39225726, DOI: 10.1007/s00428-024-03914-5.Peer-Reviewed Original ResearchConceptsFollicular nodular diseaseAnaplastic thyroid carcinomaPapillary thyroid carcinomaEIF1AX mutationsBenign thyroid nodulesThyroid carcinomaThyroid nodulesOncocytic adenomasMolecular alterationsGenetic abnormalitiesNon-invasive follicular thyroid neoplasmPapillary-like nuclear featuresAssociated with malignant tumorsWHO 5th EditionCancer referral centerFollicular thyroid neoplasmTertiary care hospitalOncocytic carcinomaThyroid neoplasmsReferral centerNodular diseasePathological diagnosisCancer Genome AtlasMalignant tumorsEIF1AXSeven years of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Rate of Acceptance and Variation of Diagnostic Approaches Across Different Continents
Williams M, Liu Z, Rossi E, Agarwal S, Ryška A, Al Ghuzlan A, Bychkov A, Baloch Z, Chernock R, Chiosea S, Cipriani N, Erkilic S, Fridman M, Hang J, Harahap A, Jung C, Kakudo K, Khalil M, Khanafshar E, Kumarasinghe P, Lloyd R, Nguyen T, Ocal I, Prasad M, Pusztaszeri M, Rana C, Sadow P, Sajed D, Seethala R, Tallini G, Vuong H, Yegen G, LiVolsi V, Nikiforov Y. Seven years of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Rate of Acceptance and Variation of Diagnostic Approaches Across Different Continents. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae354. PMID: 38874075, DOI: 10.1210/clinem/dgae354.Peer-Reviewed Original ResearchConceptsPapillary-like nuclear featuresFollicular thyroid neoplasmPapillary thyroid carcinomaNuclear scoreThyroid neoplasmsWhole slide imagesEncapsulated follicular variant of papillary thyroid carcinomaFollicular variant of papillary thyroid carcinomaNoninvasive encapsulated follicular variant of papillary thyroid carcinomaVariant of papillary thyroid carcinomaNuclear featuresNoninvasive follicular thyroid neoplasmNon-invasive follicular thyroid neoplasmIncidence of NIFTPAdoption rateSlide imagesDiagnosing NIFTPNIFTP diagnosisThyroid carcinomaEndocrine pathologistsNIFTPDiagnosing lesionsNorth AmericaDiagnostic approachPractice patternsSingle-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue
Venkat A, Carlino M, Lawton B, Prasad M, Amodio M, Gibson C, Zeiss C, Youlten S, Krishnaswamy S, Krause D. Single-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue. Genome Research 2024, 34: 837-850. PMID: 38977309, PMCID: PMC11293540, DOI: 10.1101/gr.278215.123.Peer-Reviewed Original ResearchConceptsCell statesMitochondrial transcript abundanceParathyroid glandsHuman parathyroidCell-cell communication analysisRNA expression analysisSingle-cell analysisTranscriptional dynamicsTranscript abundanceExpression dynamicsRNA transcriptomeEpithelial cell statesCell abundanceExpression analysisPseudotime analysisImpact of 18F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning–Generated Biomarkers
Haider S, Zeevi T, Sharaf K, Gross M, Mahajan A, Kann B, Judson B, Prasad M, Burtness B, Aboian M, Canis M, Reichel C, Baumeister P, Payabvash S. Impact of 18F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning–Generated Biomarkers. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266637. PMID: 38514087, DOI: 10.2967/jnumed.123.266637.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaSquamous cell carcinomaHuman papillomavirusRadiomic featuresIntraclass correlation coefficientCell carcinomaLentiform nucleusHuman papillomavirus statusReceiver-operating-characteristic analysisReceiver-operating-characteristic curvePET radiomic featuresUnivariate logistic regressionF-FDGPrimary tumorTraining cohortValidation cohortRadiomic biomarkersUnivariate analysisInterindividual comparabilityPredictive valueDegree of reproducibilityMedian areaRadiomic markersLogistic regressionAUCMolecular Genetics Augment Cytopathologic Evaluation and Surgical Planning of Pediatric Thyroid Nodules
Spaulding S, Maayah M, Dinauer C, Prasad M, Darbinyan A, Morotti R, Christison-Lagay E. Molecular Genetics Augment Cytopathologic Evaluation and Surgical Planning of Pediatric Thyroid Nodules. Journal Of Pediatric Surgery 2024, 59: 975-980. PMID: 38246817, DOI: 10.1016/j.jpedsurg.2024.01.001.Peer-Reviewed Original ResearchConceptsFine-needle aspiration biopsyPediatric thyroid nodulesMolecular genetic testingBethesda IV nodulesPrediction of malignancyDICER1 mutationsThyroid nodulesGenetic testingNRAS mutationsMethods Retrospective chart reviewRetrospective chart reviewTime of surgeryBRAF V600E testingMutations/fusionsBethesda III nodulesChart reviewSurgical resectionFinal histopathologyThyroid resectionPediatric dataHistologic classificationSurgical specimensBRAF mutationsAspiration biopsyCytopathologic evaluation
2023
Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry
Meiklejohn K, Hrones M, Wang M, Prasad M, Cai G, Adeniran A, Gilani S. Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry. Cytopathology 2023, 34: 219-224. PMID: 36825365, DOI: 10.1111/cyt.13222.Peer-Reviewed Original ResearchGrading system for medullary thyroid carcinoma; an institutional experience
Podany P, Meiklejohn K, Garritano J, Holt E, Barbieri A, Prasad M, Gilani S. Grading system for medullary thyroid carcinoma; an institutional experience. Annals Of Diagnostic Pathology 2023, 64: 152112. PMID: 36736129, DOI: 10.1016/j.anndiagpath.2023.152112.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsMedullary thyroid carcinomaTwo-tier grading systemDistant metastasisNuclear pleomorphismGrading systemNodal diseaseOverall survivalVascular invasionMTC casesThyroid carcinomaMedullary thyroid carcinoma casesMultivariate Cox regressionThyroid carcinoma casesCohort of casesRisk stratificationCox regressionTumor gradePathology reportsCarcinoma casesInstitutional experienceThyroid malignancyTumor fibrosisHG groupProminent nucleoliRare type
2021
Anaplastic thyroid carcinoma: diagnostic challenges, histopathologic features and ancillary testing
Gilani S, Khan M, Barbieri A, Prasad M. Anaplastic thyroid carcinoma: diagnostic challenges, histopathologic features and ancillary testing. Diagnostic Histopathology 2021, 27: 263-271. DOI: 10.1016/j.mpdhp.2021.03.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAnaplastic thyroid carcinomaDiagnostic challengeAggressive thyroid malignancyHigh mortality rateThyroid follicular cellsCompressive symptomsHistopathologic featuresCarcinoma componentThyroid malignancyAncillary testingThyroid carcinomaMortality rateDiagnostic limitationsFollicular cellsHistopathologic variabilityPaucicellular specimensMalignancyMolecular featuresPainCarcinomaSymptoms
2020
Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG)
Xu B, Barbieri AL, Bishop JA, Chiosea SI, Dogan S, Di Palma S, Faquin WC, Ghossein R, Hyrcza M, Jo VY, Lewis JS, Lozada JR, Michal M, Pareja FG, Perez-Ordonez B, Prasad ML, Purgina B, Reis-Filho JS, Scognamiglio T, Sebastiao APM, Seethala RR, Skálová A, Smith SM, Tekkeşin MS, Thompson LDR, Wasseman JK, Wenig BM, Weinreb I, Katabi N. Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG). The American Journal Of Surgical Pathology 2020, 44: 545-552. PMID: 31917707, PMCID: PMC7437128, DOI: 10.1097/pas.0000000000001431.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsMeSH KeywordsAdenocarcinomaBiomarkers, TumorBiopsyCanadaDNA Mutational AnalysisEuropeGene FusionGenetic Predisposition to DiseaseHumansIn Situ Hybridization, FluorescenceMutationObserver VariationPredictive Value of TestsReal-Time Polymerase Chain ReactionReproducibility of ResultsSalivary Gland NeoplasmsUnited StatesConceptsPapillary architectureIndeterminate featuresPolymorphous adenocarcinomaConsensus diagnosisCribriform adenocarcinomaInterobserver agreementSalivary glandsFair interobserver agreementNeck pathologistHistologic diversityHistologic classificationMorphologic spectrumDiagnostic concordanceSolid patternMolecular alterationsAdenocarcinomaGlomeruloid structuresTumorsLevel of agreementHotspot mutationsClear nucleiModerate agreementExpert pathologistsSuch molecular eventsMolecular signatures
2018
Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology
Nicolson NG, Murtha TD, Dong W, Paulsson JO, Choi J, Barbieri AL, Brown TC, Kunstman JW, Larsson C, Prasad ML, Korah R, Lifton RP, Juhlin CC, Carling T. Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2640-2650. PMID: 29726952, DOI: 10.1210/jc.2018-00277.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsFollicular thyroid carcinomaThyroid carcinomaMutation burdenWorse disease-specific survivalDisease-specific survivalDifferent histopathological subtypesWorld Health Organization guidelinesSomatic mutationsNonsynonymous somatic mutationsHealth Organization guidelinesTotal mutation burdenIndependent predictorsWorse prognosisHistopathological subtypesPatient outcomesHistopathological classificationInvasive subtypesClinicopathologic parametersMutational burdenSurvival analysisSomatic copy number alterationsCopy number alterationsSubtypesOrganization guidelinesMore subclones
Clinical Care
Overview
Manju Prasad, MD, MBBS, (a medical degree awarded in several countries outside of the U.S.),a pathologist who specializes in head and neck cancer, learned about this disease when several family members developed this kind of cancer. “My original ideas for joining medicine were very idealistic, and I realized that by studying pathology, I could directly help patients by giving them correct diagnoses and guide their treatment by talking to their surgeons, medical oncologists and internists,” Dr. Prasad says.
“Every day, I look at cancer cells under a microscope in an attempt to provide oncologists with details like whether the cancer is slow- or fast-growing, or what stage has the cancer reached,” Dr. Prasad says. She also regularly assists in cancer-related surgeries by providing rapid intraoperative diagnoses. This type of diagnosis occurs when the surgeon removes a piece of tissue around a patient’s tumor and sends it to the pathologist. The pathologist then examines the sample microscopically using the frozen section diagnostic technique to determine if the cancer has been entirely removed or if the surgeon needs to do more.
At Yale School of Medicine, Dr. Prasad is professor of pathology and director of endocrine, head and neck pathology. She researches specific proteins, or molecules, found in thyroid, salivary and head and neck cancers in order to determine possible new drug therapy targets.
Clinical Specialties
Fact Sheets
Head and Neck Cancer
Learn More on Yale Medicine
Board Certifications
Anatomic & Clinical Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 1998
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View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
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Media
- Nodules of tumor cells infiltrating thyroid tissue and blood vessels
- The patient was an 80-year-old man who was coughing blood. The thyroid tumor was massive and had eroded through his trachea leading to coughing and bleeding. The tumor is a tall cell variant of papillary thyroid carcinoma.
News
- January 10, 2023
Yale Cancer Center Presents Awards for Excellence in Clinical Care
- May 02, 2022
Yale Pathology Diagnostic Pathology CME Annual Review Scheduled for September 17-18 at Yale Club of NYC
- April 05, 2022
Manju Prasad, MD, MBBS, on Head and Neck Cancer Awareness Month
- March 18, 2022
Yale Pathologists Participating in Annual USCAP Meeting to Share Research, Advancements
Get In Touch
Contacts
Locations
Department of Pathology
Academic Office
Brady Memorial Laboratory
310 Cedar Street, Wing Lauder Hall, Fl 2nd, Ste LH-222
New Haven, CT 06510
Fax
203.737.2470Clinical Inquiry
203.785.2788Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.