Shan Xin
Associate Research Scientist in GeneticsAbout
Research
Publications
2026
Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT
Baysoy A, Tian X, Renauer P, Zhang F, Bai Z, Shi H, Yang M, Zhang D, Liu M, Li H, Tao B, Enninful A, Lu Y, Gao F, Wang G, Zhang W, Tran T, Patterson N, Sheng J, Bao S, Dong C, Xin S, Chen B, Zhong M, Rankin S, Guy C, Wang Y, Connelly J, Pruett-Miller S, Wang D, Xu M, Gerstein M, Chi H, Chen S, Fan R. Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT. Nature Biotechnology 2026, 1-14. PMID: 42277225, DOI: 10.1038/s41587-026-03127-y.Peer-Reviewed Original ResearchThis study introduces Perturb-DBiT, a method enabling spatially resolved CRISPR screens and transcriptomics in tissues, uncovering genetic and RNA-level mechanisms driving cancer and immune interactions.AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling
Liu C, Hu C, Cheng J, Xin D, Jin S, Tian W, Li S, Jin Y, Liu Y, Wu W, Hao S, Ren H, Dai X, Liu L, Ruan J, Fang W, Bao X, Xin S, Zhao P. AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling. Journal For ImmunoTherapy Of Cancer 2026, 14: e013305. PMID: 41807033, PMCID: PMC12983827, DOI: 10.1136/jitc-2025-013305.Peer-Reviewed Original ResearchRational Design of Immune Gene Therapy Combinations via In Vivo CRISPR Activation Screen of Tumor Microenvironment Modulators.
Zhang F, Dong C, Chow R, Xin S, He E, Feng Y, Zhu L, Mirza D, Tian X, Yang L, Zhou L, Ling X, Han Q, Fan R, Chen S, Wang G. Rational Design of Immune Gene Therapy Combinations via In Vivo CRISPR Activation Screen of Tumor Microenvironment Modulators. Cancer Discovery 2026, 16: 1222-1244. PMID: 41747251, DOI: 10.1158/2159-8290.cd-25-0545.Peer-Reviewed Original ResearchHigh-resolution spatial multi-omics enables prognostic scoring in intrahepatic cholangiocarcinoma
Jin Y, Mei J, Cheng J, Liu Q, Hong L, Gao L, Xie L, Sun X, Tang Y, Xin S, Shi Y, Dai X, Tong Z, Zhang H, Fu W, Chen J, Ruan J, Fang W, Yun J, Deng H, Wei W, Lin B, Zhao P, Bao X. High-resolution spatial multi-omics enables prognostic scoring in intrahepatic cholangiocarcinoma. Molecular Therapy 2026, 34: 3616-3635. PMID: 41709577, PMCID: PMC13246304, DOI: 10.1016/j.ymthe.2026.02.029.Peer-Reviewed Original Research
2025
Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy response
Zhang H, Hong L, Dong Z, Xin S, Lin B, Cheng J, Tian W, Li B, Wang J, Liu X, Liu C, Jin Y, Feng Y, Su G, Sun X, Liu Q, Dai X, Gao Y, Tong Z, Liu L, Zhu X, Zheng Y, Zhao P, Guo T, Fang W, Bao X. Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy response. Cell Discovery 2025, 11: 60. PMID: 40593467, PMCID: PMC12219098, DOI: 10.1038/s41421-025-00811-2.Peer-Reviewed Original ResearchSpatial multi-omics profiling of breast cancer oligo-recurrent lung metastasis
Gao Y, Li B, Jin Y, Cheng J, Tian W, Ying L, Hong L, Xin S, Lin B, Liu C, Sun X, Zhang J, Zhang H, Xie J, Deng X, Dai X, Liu L, Zheng Y, Zhao P, Yu G, Fang W, Bao X. Spatial multi-omics profiling of breast cancer oligo-recurrent lung metastasis. Oncogene 2025, 44: 2268-2282. PMID: 40234722, DOI: 10.1038/s41388-025-03388-y.Peer-Reviewed Original ResearchCas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering
Tang K, Zhou L, Tian X, Fang S, Vandenbulcke E, Du A, Shen J, Cao H, Zhou J, Chen K, Kim H, Luo Z, Xin S, Lin S, Park D, Yang L, Zhang Y, Suzuki K, Majety M, Ling X, Lam S, Chow R, Ren P, Tao B, Li K, Codina A, Dai X, Shang X, Bai S, Nottoli T, Levchenko A, Booth C, Liu C, Fan R, Dong M, Zhou X, Chen S. Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering. Nature Biomedical Engineering 2025, 9: 1290-1308. PMID: 40114032, PMCID: PMC12360953, DOI: 10.1038/s41551-025-01371-2.Peer-Reviewed Original ResearchExploring FAM13A-N-Myc interactions to uncover potential targets in MYCN-amplified neuroblastoma: a study of protein interactions and molecular dynamics simulations
Yin H, Liu T, Wu D, Li X, Li G, Song W, Wang X, Xin S, Liu Y, Pan J. Exploring FAM13A-N-Myc interactions to uncover potential targets in MYCN-amplified neuroblastoma: a study of protein interactions and molecular dynamics simulations. BMC Cancer 2025, 25: 470. PMID: 40087586, PMCID: PMC11907995, DOI: 10.1186/s12885-025-13903-9.Peer-Reviewed Original ResearchSpatial single-cell proteomics landscape decodes the tumor microenvironmental ecosystem of intrahepatic cholangiocarcinoma
Hong L, Mei J, Sun X, Wu Y, Dong Z, Jin Y, Gao L, Cheng J, Tian W, Liu C, Li B, Hu P, Liu L, Xin S, Dai X, Zhao P, Guo R, Chen M, Yun J, Lin B, Wei W, Fang W, Bao X. Spatial single-cell proteomics landscape decodes the tumor microenvironmental ecosystem of intrahepatic cholangiocarcinoma. Hepatology 2025, 83: 57-74. PMID: 39999448, DOI: 10.1097/hep.0000000000001283.Peer-Reviewed Original ResearchAuthor Correction: Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy
Zhang F, Chow R, He E, Dong C, Xin S, Mirza D, Feng Y, Tian X, Verma N, Majety M, Zhang Y, Wang G, Chen S. Author Correction: Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy. Nature Biotechnology 2025, 43: 2068-2068. PMID: 39901026, DOI: 10.1038/s41587-025-02576-1.Commentaries, Editorials and Letters
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