Amos Espinosa
he/him/his
About
Research
Publications
2025
RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation
Mayday M, Biancon G, Wei M, Ramirez C, Moratti I, Pintado-Urbanc A, Espinosa J, Chen M, Wang L, Simon M, Ofir-Rosenfeld Y, Rausch O, Tebaldi T, Halene S, Krause D. RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation. Blood 2025, 146: 1096-1109. PMID: 40435410, PMCID: PMC12783520, DOI: 10.1182/blood.2024027712.Peer-Reviewed Original ResearchRNA fatem6A modificationfusion proteinWnt pathway activationFrizzled genesfunctions of RBM15dysregulation of m6A modificationRBM15-MKL1pathway activationmulti-omics approachinduced apoptosis in vitroWnt Signaling Pathwayapoptosis in vitrom6A depositionRNA bindingspecific RNAgrowth in vitrom6A methylationmRNA targetssignaling pathwayWnt pathwayWnt signalingm6A modifiersm6A-dependent mechanismRNA
2021
Real‐Time Assessment of Mitochondrial Toxicity in HepG2 Cells Using the Seahorse Extracellular Flux Analyzer
Espinosa J, Pohan G, Arkin M, Markossian S. Real‐Time Assessment of Mitochondrial Toxicity in HepG2 Cells Using the Seahorse Extracellular Flux Analyzer. Current Protocols 2021, 1: e75. PMID: 33735523, DOI: 10.1002/cpz1.75.Peer-Reviewed Original ResearchReimagining dots and dashes: Visualizing structure and function of organelles for high-content imaging analysis
Chin M, Espinosa J, Pohan G, Markossian S, Arkin M. Reimagining dots and dashes: Visualizing structure and function of organelles for high-content imaging analysis. Cell Chemical Biology 2021, 28: 320-337. PMID: 33600764, PMCID: PMC7995685, DOI: 10.1016/j.chembiol.2021.01.016.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
Multiparametric High‐Content Assays to Measure Cell Health and Oxidative Damage as a Model for Drug‐Induced Liver Injury
Pohan G, Espinosa J, Chen S, Ang K, Arkin M, Markossian S. Multiparametric High‐Content Assays to Measure Cell Health and Oxidative Damage as a Model for Drug‐Induced Liver Injury. Current Protocols In Chemical Biology 2020, 12: e90-e90. PMID: 33315311, PMCID: PMC8269189, DOI: 10.1002/cpch.90.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
News
- July 08, 2026
National Cancer Institute Grant Will Support Espinosa’s Leukemia Research
- December 31, 2024
Accolades, Awards & Honors
- December 18, 2024
Yale research advances presented at American Society of Hematology annual meeting
- May 08, 2024
Amos Espinosa Wins American Society of Hematology Minority Hematology Graduate Award