Lin Wang, MS
Research Associate Laboratory MedicineDownloadHi-Res Photo
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Research Associate Laboratory Medicine
Biography
Lin Wang has been a Research Associate in the Krause’s laboratory for over 20 years. She received her Master’s Degree from the University of New Haven in molecular/cellular biology. She is highly trained in molecular/cellular biology, protein biochemistry and cell culture including primary murine and human cells. Her interests outside of the laboratory include her family, gardening, hiking, backpacking, photography (including aerial photography), and volunteering for the community. She has been bagged 40 out of the 48 ‘high peaks’ in New Hampshire, and has climbed more than half of the 4000 ft peaks (total 115) in the northeastern US. Both science and nature make life fun!
Last Updated on August 12, 2026.
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Education & Training
- MS
- University of New Haven, Molecular/Cell Biology (2003)
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Lin Wang's published research.
Publications Timeline
A big-picture view of Lin Wang's research output by year.
Diane Krause, MD, PhD
Emanuela Bruscia, PhD
Stephanie Halene, MD, Dr Med
Vanessa Scanlon, PhD
Clemente Britto-Leon, MD
Giulia Biancon, PhD
11Publications
403Citations
Publications
2025
RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation
Mayday M, Biancon G, Wei M, Ramirez C, Moratti I, Pintado-Urbanc A, Espinosa J, Chen M, Wang L, Simon M, Ofir-Rosenfeld Y, Rausch O, Tebaldi T, Halene S, Krause D. RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation. Blood 2025, 146: 1096-1109. PMID: 40435410, PMCID: PMC12783520, DOI: 10.1182/blood.2024027712.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRNA fateM6A modificationFusion proteinWnt pathway activationFrizzled genesFunctions of RBM15Dysregulation of m6A modificationRBM15-MKL1Pathway activationMulti-omics approachInduced apoptosis in vitroWnt Signaling PathwayApoptosis in vitroM6A depositionRNA bindingSpecific RNAGrowth in vitroM6A methylationMRNA targetsSignaling pathwayWnt pathwayWnt signalingM6A modifiersM6A-dependent mechanismRNA
2024
CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in megakaryocytic-erythroid progenitors
Kwon N, Lu Y, Thompson E, Mancuso R, Wang L, Zhang P, Krause D. CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in megakaryocytic-erythroid progenitors. Blood 2024, 144: 1800-1812. PMID: 39102635, PMCID: PMC11530366, DOI: 10.1182/blood.2024023963.Peer-Reviewed Original ResearchCitationsAltmetricConceptsmegakaryocytic-erythroid progenitorswild-typefate specificationRUNX1 levelscell lines expressing wild-typehuman erythroleukemiainhibition of CDK9cell-type specific transcription factorsMK-specificRUNX1 variantsdifferentially regulates expressionerythroid commitmenthematopoietic homeostasishuman erythroleukemia cellsMK progenitorsoverexpression of RUNX1megakaryocyte fatedecreased expressionRUNX1mimetic mutationnon-phosphorylatabletranscription machineryfunctional efficacyserine/threonine phosphorylationserine/threonine kinase
2022
Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization.
Reed FE, Eskow NM, Min E, Carlino M, Mancuso R, Kwon N, Smith EC, Larsuel ST, Wang L, Scanlon V, Krause DS. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. Haematologica 2022 PMID: 36005559.Peer-Reviewed Original ResearchStructure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization
Reed F, Eskow N, Min E, Carlino M, Mancuso R, Kwon N, Smith E, Larsuel S, Wang L, Scanlon V, Krause D. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. Haematologica 2022, 107: 2972-2976. PMID: 36453520, PMCID: PMC9713552, DOI: 10.3324/haematol.2021.280499.Peer-Reviewed Original ResearchCitationsAltmetric
2018
The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification
Lu YC, Sanada C, Xavier-Ferrucio J, Wang L, Zhang PX, Grimes HL, Venkatasubramanian M, Chetal K, Aronow B, Salomonis N, Krause DS. The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification. Cell Reports 2018, 25: 3229. PMID: 30540953, PMCID: PMC6357951, DOI: 10.1016/j.celrep.2018.11.075.Commentaries, Editorials and LettersCitationsAltmetricSurfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair
Jin H, Ciechanowicz AK, Kaplan AR, Wang L, Zhang P, Lu YC, Tobin RE, Tobin BA, Cohn L, Zeiss CJ, Lee PJ, Bruscia EM, Krause DS. Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2018, 314: l882-l892. PMID: 29345196, PMCID: PMC6008135, DOI: 10.1152/ajplung.00418.2017.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsacute respiratory distress syndromeKO micesurfactant protein Cclinical acute respiratory distress syndromeprotein Calveolar type 2 cellsanti-inflammatory mediatorsrespiratory distress syndromebronchoalveolar lavage fluidanti-inflammatory moleculesphosphorylated signal transductiontype 2 cellsSPC expressioninducible suicide geneJanus kinaselevels of suppressordistress syndromeBAL fluidgranulocyte infiltrationJAK1/2 inhibitorlavage fluidproinflammatory phenotypeinflammatory cytokinessevere inflammationinjury model
2017
Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages
Di Pietro C, Zhang PX, O’Rourke T, Murray TS, Wang L, Britto CJ, Koff JL, Krause DS, Egan ME, Bruscia EM. Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages. Scientific Reports 2017, 7: 10882. PMID: 28883468, PMCID: PMC5589856, DOI: 10.1038/s41598-017-11012-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsCell LineCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorCytoskeletal ProteinsDisease Models, AnimalMacrophage ActivationMacrophagesMicePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPseudomonas aeruginosaPseudomonas InfectionsSignal TransductionToll-Like Receptor 4Conceptscystic fibrosis transmembrane conductance regulatorPI3K/Aktfibrosis transmembrane conductance regulatortransmembrane conductance regulatorPI3K/Akt signalingconductance regulatoranti-bacterial immune responseAkt signalingaltered localizationezrincystic fibrosis diseaseMφ activationAktprotein levelsfibrosis diseaseactivationimmune regulationphagocytosisinductiondirect linksignalingregulatorimmune responseMΦmacrophages
2016
ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction
Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y. ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction. JCI Insight 2016, 1: e80920. PMID: 27525311, PMCID: PMC4982472, DOI: 10.1172/jci.insight.80920.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMyocardial infarctionControl animalsCardiovascular progenitor cellsProgenitor cellsVentricular contractile functionCardiac repair strategiesNew blood vesselsInfarct areaLineage-tracing studiesContractile functionCardiac repairBlood vessel formationMyocardial regenerationEndothelial cellsHeart tissueBlood vesselsMurine heartInfarctionVessel formationInjuryMiceDelivery approachCardiomyocytesHeartCells
2012
Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation
Smith EC, Teixeira AM, Chen RC, Wang L, Gao Y, Hahn KL, Krause DS. Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation. Blood 2012, 121: 1094-1101. PMID: 23243284, PMCID: PMC3575755, DOI: 10.1182/blood-2012-05-429993.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsActinsAnimalsCell DifferentiationCell Line, TumorCell NucleusDNA-Binding ProteinsEnzyme ActivationHumansMegakaryocyte Progenitor CellsMegakaryocytesMiceOncogene Proteins, FusionProtein MultimerizationrhoA GTP-Binding ProteinSerum Response FactorTetradecanoylphorbol AcetateThrombopoietinTrans-ActivatorsConceptsMegakaryocyte differentiationActin polymerizationSubcellular localizationSerum response factor (SRF) transcriptional activityRhoA activitySRF target genesComplex cellular responsesFactor transcriptional activityMuscle cell typesCell-type specificHuman erythroleukemia cellsPrimary megakaryocytesTranscriptional regulatorsActin organizationCellular functionsTranscriptional functionSRF activityNuclear localizationTarget genesMegakaryocytic differentiationTranscriptional activityNuclear accumulationErythroleukemia cellsMolecular mechanismsRhoA activationRole of RhoA-Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes
Gao Y, Smith E, Ker E, Campbell P, Cheng EC, Zou S, Lin S, Wang L, Halene S, Krause DS. Role of RhoA-Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes. Developmental Cell 2012, 22: 573-584. PMID: 22387001, PMCID: PMC3306542, DOI: 10.1016/j.devcel.2011.12.019.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGEF-H1Efficient platelet productionExchange factor GEF-H1Guanine exchange factorGEF-H1 knockdownDevelopment of aneuploidyGEF-H1 expressionMK polyploidizationExchange factorPloidy defectsAberrant mitosisDevelopmental processesExogenous expressionPolyploidizationRhoA activationEndomitotic cyclePrimary cellsUnknown mechanismMechanistic insightsECT2EndomitosisAneuploid cancersPlatelet productionMegakaryocytesDownregulation
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