Allison Campbell, MD, PhD
Assistant Professor of Therapeutic RadiologyCards
About
Research
Publications
2026
Consolidative Radiotherapy for Extensive-Stage Small Cell Lung Cancer: Outcomes Based on Completeness of Consolidation and Oligometastatic State
Ninia JG, Verma N, Long JB, Laird JH, Hicks DF, Hayman TJ, Knowlton CA, Campbell AM, Housri N, Peters GW, Al Feghali KA, de Jong D, Chiang AC, Park HS. Consolidative Radiotherapy for Extensive-Stage Small Cell Lung Cancer: Outcomes Based on Completeness of Consolidation and Oligometastatic State. Clinical Lung Cancer 2026, 27 DOI: 10.1016/j.cllc.2026.03.009.Peer-Reviewed Original ResearchConsolidative Radiotherapy for Extensive-Stage Small Cell Lung Cancer: Outcomes Based on Completeness of Consolidation and Oligometastatic State
Ninia J, Verma N, Long J, Laird J, Hicks D, Hayman T, Knowlton C, Campbell A, Housri N, Peters G, Al Feghali K, de Jong D, Chiang A, Park H. Consolidative Radiotherapy for Extensive-Stage Small Cell Lung Cancer: Outcomes Based on Completeness of Consolidation and Oligometastatic State. Clinical Lung Cancer 2026, 27: 14-23. PMID: 42019269, DOI: 10.1016/j.cllc.2026.03.009.Peer-Reviewed Original ResearchConceptsExtensive-stage small cell lung cancerProgression-free survivalSmall cell lung cancerOverall survivalCell lung cancerMetastatic stateConsolidation radiotherapyOligometastatic statusRestricted mean survival timeExtensive-stage small cell lung cancer patientsLung cancerProgression-free survival gainFirst-line systemic therapyEastern Cooperative Oncology Group statusTarget residual diseaseMedian Follow-UpLog-rank testRetrospective cohort studyMean survival timeImmunotherapy receiptOligometastatic stateOligometastatic patientsResidual diseaseRT completionSystemic therapy
2024
NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7
Gordon R, Cosgrove H, Marinov A, Gingras S, Tilstra J, Campbell A, Bastacky S, Kashgarian M, Perl A, Nickerson K, Shlomchik M. NADPH oxidase in B cells and macrophages protects against murine lupus by regulation of TLR7. JCI Insight 2024, 9: e178563. PMID: 39042716, PMCID: PMC11343599, DOI: 10.1172/jci.insight.178563.Peer-Reviewed Original ResearchSystemic lupus erythematosusB cellsRegulation of TLR7Cell lineagesNADPH oxidaseHematopoietic cell lineagesNF-kB signalingSLE pathologyNOX2 deficiencyMyeloid compartmentMurine lupusLupus nephritisLupus erythematosusTLR7 signalingGlobal deletionInterstitial nephritisImmunomodulatory effectsGlobal knockoutConditional knockoutCYBBNOX2NephritisKnockoutTLR7Chimera approachRadioresistant Pulmonary Oligometastatic and Oligoprogressive Lesions From Nonlung Primaries: Impact of Histology and Dose-Fractionation on Local Control After Radiation Therapy
Verma N, Laird J, Moore N, Hayman T, Housri N, Peters G, Knowlton C, Jairam V, Campbell A, Park H. Radioresistant Pulmonary Oligometastatic and Oligoprogressive Lesions From Nonlung Primaries: Impact of Histology and Dose-Fractionation on Local Control After Radiation Therapy. Advances In Radiation Oncology 2024, 9: 101500. PMID: 38699671, PMCID: PMC11063223, DOI: 10.1016/j.adro.2024.101500.Peer-Reviewed Original ResearchLocal recurrence-free survivalNon-lung primaryAssociated with higher local recurrence-free survivalProgression-free survivalBiologically Effective DoseLocal controlRadioresistant metastasesOverall survivalPulmonary metastasesPrimary cancerColorectal carcinomaAssociated with superior local controlMultivariate analysisPatients treated with radiotherapyRisk of local recurrenceMedian follow-up timeMultivariable Cox proportional hazards regressionInferior local controlMedian total doseSuperior local controlAssociated with decreased riskImpact of histologyMetastasis-free survivalRecurrence-free survivalLocal failure
2023
Dose-Volume Predictors of Radiation Pneumonitis After Thoracic Hypofractionated Radiation Therapy
Sasse A, Oh P, Saeed N, Yang D, Hayman T, Knowlton C, Peters G, Campbell A, Laird J, Housri N, Park H. Dose-Volume Predictors of Radiation Pneumonitis After Thoracic Hypofractionated Radiation Therapy. Practical Radiation Oncology 2023, 14: e97-e104. PMID: 37984711, DOI: 10.1016/j.prro.2023.11.006.Peer-Reviewed Original ResearchMean lung doseHypofractionated radiation therapyRisk of gradeRadiation pneumonitisLung V20Lung V5Dose-volume predictorsDosimetric risk factorsLogistic regression analysisGrade 5 casesSingle healthcare systemPrimary endpointDose regimensMultivariable analysisLung doseThoracic tumorsDosimetric variablesRisk factorsPneumonitisRadiation therapyCommon treatmentClinical practicePatientsSignificant associationPotential predictors
2020
Parallels Between the Antiviral State and the Irradiated State
McGee HM, Marciscano AE, Campbell AM, Monjazeb AM, Kaech SM, Teijaro JR. Parallels Between the Antiviral State and the Irradiated State. Journal Of The National Cancer Institute 2020, 113: 969-979. PMID: 33252657, PMCID: PMC8502484, DOI: 10.1093/jnci/djaa190.Peer-Reviewed Original ResearchConceptsHost antiviral defenseType I interferon responseI interferon responseViral mimicryAntiviral defenseHost cellsMolecular pathwaysAntiviral statePathogen controlAntiviral responseViral infectionInterferon responseHost defensePathwayDNADanger signalsAntitumor immunityTumor controlRecent studiesSterile inflammationDefenseTumor cellsTumor DNACellsRNA
2019
Exploring single-cell data with deep multitasking neural networks
Amodio M, van Dijk D, Srinivasan K, Chen WS, Mohsen H, Moon KR, Campbell A, Zhao Y, Wang X, Venkataswamy M, Desai A, Ravi V, Kumar P, Montgomery R, Wolf G, Krishnaswamy S. Exploring single-cell data with deep multitasking neural networks. Nature Methods 2019, 16: 1139-1145. PMID: 31591579, PMCID: PMC10164410, DOI: 10.1038/s41592-019-0576-7.Peer-Reviewed Original Research
2018
Harnessing the Immunomodulatory Effects of Radiation Therapy.
Campbell AM, Decker RH. Harnessing the Immunomodulatory Effects of Radiation Therapy. Oncology 2018, 32: 370-4, cv3. PMID: 30080922.Peer-Reviewed Original ResearchConceptsImmunomodulatory effectsImmune responseImmune systemSetting of cancerSystemic immune responsesAntitumoral immune responseInnate immune systemAdaptive immune systemCell deathTumor cell deathAntitumoral immunityAntitumoral responseHypofractionated radiationRadiotherapy timingProinflammatory responsePreclinical modelsAdaptive immunityRadiation therapyClinical informationRadiation-induced cell deathDoseImmunityDeathPotential superiorityDNA damage
2017
Lupus and proliferative nephritis are PAD4 independent in murine models
Gordon RA, Herter JM, Rosetti F, Campbell AM, Nishi H, Kashgarian M, Bastacky SI, Marinov A, Nickerson KM, Mayadas TN, Shlomchik MJ. Lupus and proliferative nephritis are PAD4 independent in murine models. JCI Insight 2017, 2: e92926. PMID: 28515361, PMCID: PMC5436537, DOI: 10.1172/jci.insight.92926.Peer-Reviewed Original ResearchSystemic lupus erythematosusNeutrophil extracellular trapsProliferative nephritisMurine modelContribution of NETsInhibition of NETsAnti-glomerular basement membrane modelEnd-organ damageLoss of toleranceRecent reportsLupus erythematosusOrgan injuryImmune activationExtracellular trapsPeptidyl arginine deiminasePharmacological approachesBasement membrane modelDistal mediatorsNADPH oxidase complexPharmacological inhibitionNephritisInducible modelLupusNET formationType IV
2015
Gamma knife stereotactic radiosurgical thalamotomy for intractable tremor: A systematic review of the literature
Campbell AM, Glover J, Chiang VL, Gerrard J, Yu JB. Gamma knife stereotactic radiosurgical thalamotomy for intractable tremor: A systematic review of the literature. Radiotherapy And Oncology 2015, 114: 296-301. PMID: 25690750, DOI: 10.1016/j.radonc.2015.01.013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStereotactic radiosurgical thalamotomyRadiosurgical thalamotomyIntractable tremorSystematic reviewUnilateral gamma knife thalamotomyOnly available treatment optionGamma knife thalamotomyAvailable treatment optionsSignificant psychological burdenQuality of lifeSurgical candidatesSevere complicationsSurgical treatmentMedical therapyTransient hemiparesisAdverse outcomesTreatment optionsPatient deathStereotactic radiosurgical techniquesMovement disordersLanguage of publicationStereotactic radiosurgeryTreatment efficacyPsychological burdenRadiosurgical techniques
Clinical Trials
Current Trials
Phase IB/II Trial Of Dose-Deescalated 3-Fraction Stereotactic Body Radiotherapy For Centrally Located Lung Cancer
IRB ID2000025868RoleSub InvestigatorPrimary Completion Date01/31/2030Recruiting ParticipantsPhase II Randomized Trial of Adjuvant Radiotherapy With or Without Cisplatin for p53 Mutated, Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN)
IRB ID1604017600RoleSub InvestigatorPrimary Completion Date12/31/2027Recruiting Participants
Clinical Care
Overview
Allison Campbell, MD, PhD, is a radiation oncologist who works with patients facing all stages of cancer. She provides radiation therapy and collaborates with other specialists to offer patients comprehensive care.
Dr. Campbell has a particular interest in treating breast cancer and in using radiosurgical approaches that involve careful coordination with neurosurgical teams. By working closely with colleagues, she focuses on delivering precise therapies designed to minimize side effects while addressing tumors effectively.
As an assistant professor of therapeutic radiology at Yale School of Medicine, Dr. Campbell’s research centers on how radiation therapy interacts with the immune system in advanced cancers. She aims to translate laboratory findings into clinical strategies that improve patient outcomes.
Dr. Campbell earned her medical degree at Yale School of Medicine and completed her residency in therapeutic radiology there, serving as chief resident. She also completed a specialized fellowship in radiosurgery at Yale School of Medicine. She also holds a doctoral degree in immunobiology.
Clinical Specialties
Therapeutic Radiology; Neurosurgery; Breast Cancer Radiotherapy
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News
- April 08, 2025
Comprehensive Breast Cancer Care at Smilow Cancer Hospital at Greenwich and Stamford
- March 20, 2025
Smilow Cancer Hospital Gynecologic Oncology Expertise in Fairfield County
- February 02, 2023
Smilow Breast Cancer Care Referrals in Greenwich and Stamford
- September 01, 2022Source: Health Extensions
Specialized Team Tackles Gynecologic Cancers
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