1992
Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120
Lipton S. Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120. Neuroreport 1992, 3: 913-915. PMID: 1421098, DOI: 10.1097/00001756-199210000-00023.Peer-Reviewed Original ResearchConceptsHIV envelope protein gp120Retinal ganglion cellsEnvelope protein gp120Neuronal injuryGanglion cellsGlial cellsProtein gp120N-methyl-D-aspartate antagonistsMixed neuronal-glial culturesRetinal ganglion cell neuronsNeuronal-glial culturesGanglion cell neuronsActivation of macrophagesPresence of macrophagesPM gp120Like damageGlial culturesCell neuronsGp120Early increaseFree calciumPostnatal retinaMacrophagesInjurious effectsNeurons
1991
Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture
Sucher N, Lei S, Lipton S. Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture. Brain Research 1991, 551: 297-302. PMID: 1680525, DOI: 10.1016/0006-8993(91)90944-q.Peer-Reviewed Original ResearchConceptsCalcium channel antagonistsRetinal ganglion cellsChannel antagonistsGanglion cellsPostnatal rat retinal ganglion cellsNMDA receptor-operated channelsRat retinal ganglion cellsNMDA receptor-mediated neurotoxicityVoltage-dependent calcium channelsSelective NMDA antagonistDihydropyridine calcium channel antagonistReceptor-operated channelsVoltage-dependent Ca2Patch-clamp recordingsNMDA antagonistsNMDA receptorsSubsequent toxic effectsCalcium channelsExogenous glutamateRetinal culturesAntagonistL-typeEarly riseInjurious effectsToxic effects