2009
Excitotoxicity in Neurodegenerative Disease
Haeberlein S, Lipton S. Excitotoxicity in Neurodegenerative Disease. 2009, 77-86. DOI: 10.1016/b978-008045046-9.00498-8.Peer-Reviewed Original ResearchHuman immunodeficiency virus-associated dementiaExcessive glutamate stimulationSpinal cord traumaMajor excitatory neurotransmitterAmyotrophic lateral sclerosisCord traumaExcitatory neurotransmitterGlutamate stimulationLateral sclerosisParkinson's diseaseTherapeutic interventionsAlzheimer's diseaseNeurodegenerative disordersDiseaseNeurodegenerative diseasesDownstream mechanismsHuntington's diseaseExcitotoxicityBrainSclerosisGlaucomaEpilepsyDementiaStrokeNeurotransmitters
1996
Elevated Glutamate Levels in the Vitreous Body of Humans and Monkeys With Glaucoma
Dreyer E, Zurakowski D, Schumer R, Podos S, Lipton S. Elevated Glutamate Levels in the Vitreous Body of Humans and Monkeys With Glaucoma. JAMA Ophthalmology 1996, 114: 299-305. PMID: 8600890, DOI: 10.1001/archopht.1996.01100130295012.Peer-Reviewed Original ResearchConceptsExcitatory amino acid glutamateRetinal ganglion cellsAmino acid glutamateVitreous bodyGlaucomatous eyesGanglion cellsGlutamate levelsRetinal ganglion cell neuronsOptic nerve damageGroup of patientsElevated glutamate levelsGanglion cell neuronsLevels of glutamateEyes of monkeysNerve damageControl eyesVisual dysfunctionNonglaucomatous eyesCataract extractionPosterior capsuleInadvertent ruptureDisease processGlaucomaCell neuronsPatients
1994
Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death
Dreyer E, Pan Z, Storm S, Lipton S. Greater sensitivity of larger retinal ganglion cells to NMDA-mediated cell death. Neuroreport 1994, 5: 629-631. PMID: 7912962, DOI: 10.1097/00001756-199401000-00024.Peer-Reviewed Original ResearchConceptsLarge retinal ganglion cellsRetinal ganglion cellsGanglion cellsGlutamate-mediated cell deathN-methyl-D-aspartate (NMDA) subtypeIntact rat eyesCell deathNeuronal lossGlutamate toxicityGlutamate receptorsRat eyesPattern of lossNMDAGlaucomaToxic effectsDeathCellsGlutamateTissue cultureGreater sensitivitySubtypesNeuronsSimilar fashionReceptors