2015
Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis
Dulay AT, Buhimschi IA, Zhao G, Bahtiyar MO, Thung SF, Cackovic M, Buhimschi CS. Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis. Cytokine 2015, 76: 236-243. PMID: 25957466, PMCID: PMC4824401, DOI: 10.1016/j.cyto.2015.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidAsymptomatic InfectionsBiomarkersCalcitoninCalcitonin Gene-Related PeptideChorioamnionitisC-Reactive ProteinFemaleFetal BloodFetal Membranes, Premature RuptureHumansInfant, NewbornInterleukin-6Obstetric Labor, PrematurePlacentaPregnancyPregnancy Complications, InfectiousPremature BirthProtein PrecursorsSystemic Inflammatory Response SyndromeConceptsIntra-amniotic infectionC-reactive proteinSubclinical intra-amniotic infectionIL-6Blood IL-6 levelsBlood IL-6Maternal blood levelsSystemic inflammatory responseIL-6 levelsNon-invasive biomarkersSubgroup of casesChorioamnionitis groupHistological chorioamnionitisInflammatory markersPreterm laborCRP levelsInflammatory biomarkersMaternal serumPlacental pathologyAcute phasePregnant womenBlood levelsSubclinical phaseInterleukin-6Cord blood
2014
A comprehensive obstetric patient safety program reduces liability claims and payments
Pettker CM, Thung SF, Lipkind HS, Illuzzi JL, Buhimschi CS, Raab CA, Copel JA, Lockwood CJ, Funai EF. A comprehensive obstetric patient safety program reduces liability claims and payments. American Journal Of Obstetrics And Gynecology 2014, 211: 319-325. PMID: 24925798, DOI: 10.1016/j.ajog.2014.04.038.Peer-Reviewed Original Research
2012
Mode of Delivery and Neonatal Outcomes in Preterm, Small-for-Gestational-Age Newborns
Werner EF, Savitz DA, Janevic TM, Ehsanipoor RM, Thung SF, Funai EF, Lipkind HS. Mode of Delivery and Neonatal Outcomes in Preterm, Small-for-Gestational-Age Newborns. Obstetrics And Gynecology 2012, 120: 560-564. PMID: 22914464, PMCID: PMC3739844, DOI: 10.1097/aog.0b013e318265b16c.Peer-Reviewed Original ResearchConceptsGestational age newbornsRespiratory distress syndromeNeonatal outcomesCesarean deliveryMethod of deliveryDistress syndromeGestational ageVaginal delivery groupIntrauterine growth restrictionMeeting study criteriaWeeks of gestationHospital discharge dataMode of deliveryLarge diverse cohortSGA newbornsVertex neonatesNeonatal morbidityPrepregnancy weightIntraventricular hemorrhageVaginal deliveryDelivery groupStudy criteriaBirth weightMaternal ageGrowth restrictionEvaluating the cost‐effectiveness of prenatal surgery for myelomeningocele: a decision analysis
Werner E, Han C, Burd I, Lipkind H, Copel J, Bahtiyar M, Thung S. Evaluating the cost‐effectiveness of prenatal surgery for myelomeningocele: a decision analysis. Ultrasound In Obstetrics And Gynecology 2012, 40: 158-164. PMID: 22511529, DOI: 10.1002/uog.11176.Peer-Reviewed Original ResearchConceptsPrenatal myelomeningocele repairQuality-adjusted life yearsMyelomeningocele repairPostnatal repairMyelomeningocele patientsPrenatal surgeryAdditional casesLong-term medical careFuture pregnancy complicationsIncremental cost-effectiveness ratioPostnatal myelomeningocele repairCost-effectiveness ratioDecision analysis modelingUterine ruptureNeurologic deficitsPregnancy complicationsSingleton gestationsSurgery resultsLife yearsMedical carePatientsCost-effective strategyNormal karyotypeNeonatesSurgery
2011
Proteomics Mapping of Cord Blood Identifies Haptoglobin “Switch-On” Pattern as Biomarker of Early-Onset Neonatal Sepsis in Preterm Newborns
Buhimschi CS, Bhandari V, Dulay AT, Nayeri UA, Abdel-Razeq SS, Pettker CM, Thung S, Zhao G, Han YW, Bizzarro M, Buhimschi IA. Proteomics Mapping of Cord Blood Identifies Haptoglobin “Switch-On” Pattern as Biomarker of Early-Onset Neonatal Sepsis in Preterm Newborns. PLOS ONE 2011, 6: e26111. PMID: 22028810, PMCID: PMC3189953, DOI: 10.1371/journal.pone.0026111.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisCord bloodNeonatal outcomesNeonatal sepsisPreterm newbornsAdverse short-term neonatal outcomesShort-term neonatal outcomesSelection of newbornsIntra-amniotic infectionIntra-ventricular hemorrhageLatent class analysisEONS diagnosisAntenatal exposurePreterm birthProspective cohortPremature newbornsAdverse outcomesInterleukin-6Odds ratioProtein immunoreactivityTargeted treatmentTwo-dimensional differential gel electrophoresisElevated haptoglobinNewbornsImportant causeUniversal cervical‐length screening to prevent preterm birth: a cost‐effectiveness analysis
Werner EF, Han CS, Pettker CM, Buhimschi CS, Copel JA, Funai EF, Thung SF. Universal cervical‐length screening to prevent preterm birth: a cost‐effectiveness analysis. Ultrasound In Obstetrics And Gynecology 2011, 38: 32-37. PMID: 21157771, DOI: 10.1002/uog.8911.Peer-Reviewed Original ResearchConceptsCervical length screeningPreterm birthVaginal progesteroneCervical lengthWeeks' gestationLong-term neurologic deficitsUniversal cervical length screeningLow-risk singleton pregnanciesTransvaginal cervical length measurementCost-effective strategyIncremental cost-effectiveness ratioTransvaginal cervical lengthVaginal progesterone supplementationCervical length measurementLow-risk pregnanciesMain outcome measuresCost-effectiveness ratioCost-effectiveness analysisDecision analysis modelNeonatal outcomesNeurologic deficitsSingleton pregnanciesProgesterone supplementationRoutine careNeonatal deathIL-6 Trans-Signaling System in Intra-Amniotic Inflammation, Preterm Birth, and Preterm Premature Rupture of the Membranes
Lee SY, Buhimschi IA, Dulay AT, Ali UA, Zhao G, Abdel-Razeq SS, Bahtiyar MO, Thung SF, Funai EF, Buhimschi CS. IL-6 Trans-Signaling System in Intra-Amniotic Inflammation, Preterm Birth, and Preterm Premature Rupture of the Membranes. The Journal Of Immunology 2011, 186: 3226-3236. PMID: 21282511, PMCID: PMC3800180, DOI: 10.4049/jimmunol.1003587.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidCytokine Receptor gp130FemaleFetal Membranes, Premature RuptureHumansInfant, NewbornInfant, PrematureInflammation MediatorsInterleukin-6Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsPregnancyPregnancy ComplicationsPremature BirthReceptors, Interleukin-6Signal TransductionYoung AdultConceptsIntra-amniotic inflammationSIL-6RIL-6RPremature ruptureIL-6Classic IL-6 signalingAF IL-6RT-PCRPreterm premature ruptureIL-6 signalingMatrix metalloprotease-9Real-time RT-PCRActivation of cellsPhysiologic constituentPreterm laborPreterm birthIL-6 TransGestational ageThird trimesterInflammatory cellsSecond trimesterNormal gestationMetalloprotease-9IL-6 bindsFetal membranes
2010
Acceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity
Azpurua H, Norwitz ER, Campbell KH, Funai EF, Pettker CM, Kleine M, Bahtiyar MO, Malkus H, Copel JA, Thung SF. Acceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity. American Journal Of Obstetrics And Gynecology 2010, 203: 40.e1-40.e8. PMID: 20417479, DOI: 10.1016/j.ajog.2010.01.075.Peer-Reviewed Original ResearchConceptsAcceleration time/ejection time ratioEjection time ratioFetal lung maturityLecithin/sphingomyelin ratioFetal pulmonary arteryLung maturitySphingomyelin ratioPulmonary arteryAcceleration/ejection time ratioPulmonary artery blood flowSystolic/diastolic ratioYale-New Haven HospitalAmniotic fluid biomarkersAmniotic fluid lecithin/sphingomyelin ratioArtery blood flowFlow velocity waveformsFlow velocity parametersNew noninvasive techniqueSingleton pregnanciesDiastolic ratioPulsatility indexUltrasound evaluationFluid biomarkersPotential confoundersStudy criteria
2009
Discussion: ‘Predicting neonatal acidemia by computer analysis’ by Costa et al
Pettker CM, Thung SF, Dulay A, Han C, Ali U. Discussion: ‘Predicting neonatal acidemia by computer analysis’ by Costa et al. American Journal Of Obstetrics And Gynecology 2009, 201: e1-e4. PMID: 19879389, DOI: 10.1016/j.ajog.2009.08.014.Peer-Reviewed Original Research
2008
Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis
Dulay AT, Buhimschi IA, Zhao G, Luo G, Abdel-Razeq S, Cackovic M, Rosenberg VA, Pettker CM, Thung SF, Bahtiyar MO, Bhandari V, Buhimschi CS. Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis. American Journal Of Obstetrics And Gynecology 2008, 198: 426.e1-426.e9. PMID: 18395034, PMCID: PMC4023236, DOI: 10.1016/j.ajog.2008.01.040.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNucleated red blood cellsInflammation-associated preterm birthNRBC countAcid-base statusIntraamniotic inflammationHistological chorioamnionitisNeonatal sepsisRed blood cellsPreterm birthGestational ageCord blood IL-6 levelsBlood IL-6 levelsFetal acid-base statusBlood cellsAbsolute NRBC countsIL-6 levelsEarly neonatal periodIntrauterine growth restrictionHours of birthEarlier gestational ageMediators of inflammationMinutes of deliveryAbsence of hypoxiaPreterm singletons
2007
Proteomic Biomarkers of Intra-amniotic Inflammation: Relationship with Funisitis and Early-onset Sepsis in the Premature Neonate
Buhimschi CS, Buhimschi IA, Abdel-Razeq S, Rosenberg VA, Thung SF, Zhao G, Wang E, Bhandari V. Proteomic Biomarkers of Intra-amniotic Inflammation: Relationship with Funisitis and Early-onset Sepsis in the Premature Neonate. Pediatric Research 2007, 61: 318-324. PMID: 17314690, DOI: 10.1203/01.pdr.0000252439.48564.37.Peer-Reviewed Original ResearchConceptsEarly-onset sepsisIntra-amniotic inflammationGestational ageScore 3Premature neonatesMR scoreEarlier gestational ageHistologic funisitisPreterm laborDelivery intervalFunisitisSepsisNeonatesCalgranulin AInflammationProteomic biomarkersCalgranulin CStrong associationHigh associationWomenSignificant correlationScoresAssociationProteomic analysisIncidence