Multidimensional Proteomics Analysis of Amniotic Fluid to Provide Insight into the Mechanisms of Idiopathic Preterm Birth
Buhimschi IA, Zhao G, Rosenberg VA, Abdel-Razeq S, Thung S, Buhimschi CS. Multidimensional Proteomics Analysis of Amniotic Fluid to Provide Insight into the Mechanisms of Idiopathic Preterm Birth. PLOS ONE 2008, 3: e2049. PMID: 18431506, PMCID: PMC2315798, DOI: 10.1371/journal.pone.0002049.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniotic FluidBiomarkersDown-RegulationElectrophoresis, Gel, Two-DimensionalFemaleHemorrhageHumansInflammationPlacentaPregnancyPregnancy ProteinsPremature BirthProteomeProteomicsRNA, MessengerSoftwareSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTreatment OutcomeUmbilical CordUp-RegulationConceptsPreterm birthAmniotic fluidIdiopathic preterm birthIntra-amniotic inflammationMost preterm birthsSubgroup of patientsAbsence of inflammationDistinct pathogenetic mechanismsFuture drug developmentProteomic fingerprintExpectant managementNovel pathogenetic pathwaysPreterm laborPremature ruptureClinical resultsPathogenetic mechanismsPathogenetic pathwaysConsecutive sampleTherapeutical interventionsInflammationSELDI peaksBirthBleedingProtein metabolismDrug developmentUsing Proteomic Analysis of the Human Amniotic Fluid to Identify Histologic Chorioamnionitis
Buhimschi IA, Zambrano E, Pettker CM, Bahtiyar MO, Paidas M, Rosenberg VA, Thung S, Salafia CM, Buhimschi CS. Using Proteomic Analysis of the Human Amniotic Fluid to Identify Histologic Chorioamnionitis. Obstetrics And Gynecology 2008, 111: 403-412. PMID: 18238979, DOI: 10.1097/aog.0b013e31816102aa.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmniocentesisAmniotic FluidBiomarkersBlack or African AmericanChorioamnionitisFemaleHumansInflammationPregnancyPregnancy Complications, InfectiousPregnancy OutcomePrevalenceProteomeProteomicsReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationWhite PeopleConceptsHistologic chorioamnionitisAmniotic fluidIntra-amniotic inflammationGrade of inflammationAbsence of biomarkersHuman amniotic fluidSurface-enhanced laser desorption ionization timeAfrican American womenPreterm laborSingleton pregnanciesDelivery intervalPlacental pathologyGestational agePremature ruptureSevere inflammationEarly recognitionChorioamnionitisChorionic plateInflammationTherapeutic interventionsProteomic biomarkersCalgranulin CBiomarkersProteomic analysisScores