2019
The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers
Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F. The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host & Microbe 2019, 26: 369-384.e8. PMID: 31513772, DOI: 10.1016/j.chom.2019.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAnimalsAntiviral AgentsChromosomal Proteins, Non-HistoneDNA Topoisomerases, Type IDNA VirusesHEK293 CellsHeLa CellsHerpesvirus 1, HumanHeterogeneous-Nuclear Ribonucleoprotein UHost-Pathogen InteractionsHumansImmunity, InnateInterferon Regulatory Factor-3Interferon Regulatory Factor-7MiceNuclear Matrix-Associated ProteinsProtein Serine-Threonine KinasesReceptors, Pattern RecognitionRNA VirusesRNA, Double-StrandedRNA, ViralVirusesConceptsImmune gene transcriptionViral RNAViral RNA sensorsChromatin remodelingTrigger innate immune responsesSuper enhancersGene transcriptionExtranuclear localizationRNA virusesInnate immune responseAntiviral genesDsRNA sensorsRNA sensorsViral dsRNAAntiviral stateAntiviral responseType I IFNDsRNAVSV infectionRobust antiviral responseRNAEnhancerI IFNImmune responseHSV-1
2018
Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3
Wang K, Zou C, Wang X, Huang C, Feng T, Pan W, Wu Q, Wang P, Dai J. Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3. PLOS Pathogens 2018, 14: e1007287. PMID: 30142214, PMCID: PMC6126873, DOI: 10.1371/journal.ppat.1007287.Peer-Reviewed Original ResearchMeSH KeywordsA549 CellsAnimalsAnophelesCells, CulturedDengue VirusGene Expression RegulationHEK293 CellsHeLa CellsHuman Umbilical Vein Endothelial CellsHumansInterferon Type IMiceProtein Processing, Post-TranslationalRNA HelicasesSerine EndopeptidasesTripartite Motif ProteinsUbiquitinationUbiquitin-Protein LigasesUp-RegulationViral Nonstructural ProteinsVirus ReplicationConceptsInterferon-stimulated genesI interferonNonstructural protein 3DENV replicationMost interferon-stimulated genesProtein 3Dengue virus infectionDengue virus replicationType I interferonViral nonstructural protein 3DENV infectionImmunocompetent miceVirus infectionViral infectionAntiviral activityVirus replicationVivo studiesInfectionTripartite motif (TRIM) proteinsTRIM family membersViral nonstructural proteinsFamily membersNonstructural proteinsTRIM69E3 ubiquitin ligase activity