2020
Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production
Truman LA, Bentley KL, Ruddle NH. Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production. European Journal Of Immunology 2020, 50: 418-425. PMID: 32012252, DOI: 10.1002/eji.201948300.Peer-Reviewed Original ResearchConceptsTertiary lymphoid organsLacrimal glandCervical lymphadenopathySjƶgren's syndromeLymphoid organsTear productionRole of lymphotoxinTLO formationAutoantibody titresMALT lymphomaLymphoid tissueTransgenic miceLymphotoxinMiceLymphadenopathyGlandSyndromeOrgansAutoimmunityMucosalLymphomaLTĪ±TitresSalivaryLTĪ²
2016
Lymphotoxin
Ruddle N. Lymphotoxin. 2016, 466-475. DOI: 10.1016/b978-0-12-374279-7.10003-7.Peer-Reviewed Original ResearchTumor necrosis factorNFĪŗB pathwayChronic inflammatory infiltrateAlternative NFĪŗB pathwayMajor histocompatibility complexLymph nodesInflammatory infiltrateChemokine expressionChronic inflammationLymphoid organsNecrosis factorImmune responseCanonical NFĪŗB pathwaySpecific antigenTNF receptorLymphotoxinLTĪ² receptorHistocompatibility complexTNF familyCulture supernatantsEmbryological developmentLymphocytesLTĪ±Cytotoxic activityReceptors