2018
Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity
Moriyama M, Igarashi M, Koshiba T, Irie T, Takada A, Ichinohe T. Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity. Journal Of Virology 2018, 92: 10.1128/jvi.00706-18. PMID: 30021900, PMCID: PMC6146818, DOI: 10.1128/jvi.00706-18.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceConserved SequenceGene Expression RegulationHost-Pathogen InteractionsHumansInfluenza A Virus, H1N1 SubtypeInterferon Regulatory Factor-3Interferon-betaInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinPhlebotomus FeverPhlebovirusPhosphorylationPromoter Regions, GeneticProtein Serine-Threonine KinasesProtein TransportSequence AlignmentSeverity of Illness IndexSignal TransductionUbiquitinationViral Nonstructural ProteinsViruses, UnclassifiedConceptsTANK-binding kinase 1SFTSV nonstructural proteinInterferon regulatory factor 3Nonstructural proteinsHost antiviral responseCytoplasmic structuresAmino acidsInterferon-beta productionKinase 1N-terminal kinase domainTick-borne phlebovirusesSFTS phlebovirusConserved amino acidsAntiviral responseC-terminal regionN-terminal regionIFN-β promoter activityPosition 21Host antiviral strategyHost innate immune systemThrombocytopenia syndrome phlebovirusRegulatory factor 3Host interferon responseKinase domainIFN-β production
2016
The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion
Moriyama M, Chen I, Kawaguchi A, Koshiba T, Nagata K, Takeyama H, Hasegawa H, Ichinohe T. The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion. Journal Of Virology 2016, 90: 4105-4114. PMID: 26865721, PMCID: PMC4810543, DOI: 10.1128/jvi.00120-16.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCarrier ProteinsHEK293 CellsHeLa CellsHumansInflammasomesInterleukin-1betaMacrophagesMice, Inbred C57BLMitochondrial MembranesNLR Family, Pyrin Domain-Containing 3 ProteinRNATranscription FactorsTripartite Motif ProteinsUbiquitin-Protein LigasesViral Nonstructural ProteinsConceptsIL-1β secretionNonstructural protein 1Virus M2 proteinSuppression of NLRP3NS1 proteinNS1 RNAInfluenza virusM2 proteinIL-18Influenza virus NS1 proteinInterleukin-1βMultimolecular protein complexesProtein 1Inflammasome-mediated IL-1β secretionLike receptor family pyrinCaspase-1New anti-inflammatory drugsVirus NS1 proteinRecent pandemic strainJ774A.1 macrophagesPrecise mechanismNLRP3 inflammasome activationAnti-inflammatory drugsProtein complexesInnate immune sensing