2019
Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses
Moriyama M, Koshiba T, Ichinohe T. Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nature Communications 2019, 10: 4624. PMID: 31604929, PMCID: PMC6789137, DOI: 10.1038/s41467-019-12632-5.Peer-Reviewed Original ResearchConceptsMitochondrial DNANonstructural protein 1Cytosolic mitochondrial DNAMtDNA releaseInfluenza virus M2Antiviral immune responseImportance of DNAVirus M2 proteinImmune responseViroporin activityMAVS-dependent mannerTriggers translocationVirus replicationCytosolic mtDNAAntiviral signalingVirus M2M2 proteinRNA virusesInnate immune responseMtDNAInfluenza virus replicationInfluenza virusNeighboring cellsProtein 1Gap junctions
2016
The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion
Moriyama M, Chen I, Kawaguchi A, Koshiba T, Nagata K, Takeyama H, Hasegawa H, Ichinohe T. The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion. Journal Of Virology 2016, 90: 4105-4114. PMID: 26865721, PMCID: PMC4810543, DOI: 10.1128/jvi.00120-16.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCarrier ProteinsHEK293 CellsHeLa CellsHumansInflammasomesInterleukin-1betaMacrophagesMice, Inbred C57BLMitochondrial MembranesNLR Family, Pyrin Domain-Containing 3 ProteinRNATranscription FactorsTripartite Motif ProteinsUbiquitin-Protein LigasesViral Nonstructural ProteinsConceptsIL-1β secretionNonstructural protein 1Virus M2 proteinSuppression of NLRP3NS1 proteinNS1 RNAInfluenza virusM2 proteinIL-18Influenza virus NS1 proteinInterleukin-1βMultimolecular protein complexesProtein 1Inflammasome-mediated IL-1β secretionLike receptor family pyrinCaspase-1New anti-inflammatory drugsVirus NS1 proteinRecent pandemic strainJ774A.1 macrophagesPrecise mechanismNLRP3 inflammasome activationAnti-inflammatory drugsProtein complexesInnate immune sensing