Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses
Moriyama M, Koshiba T, Ichinohe T. Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nature Communications 2019, 10: 4624. PMID: 31604929, PMCID: PMC6789137, DOI: 10.1038/s41467-019-12632-5.Peer-Reviewed Original ResearchConceptsMitochondrial DNANonstructural protein 1Cytosolic mitochondrial DNAMtDNA releaseInfluenza virus M2Antiviral immune responseImportance of DNAVirus M2 proteinImmune responseViroporin activityMAVS-dependent mannerTriggers translocationVirus replicationCytosolic mtDNAAntiviral signalingVirus M2M2 proteinRNA virusesInnate immune responseMtDNAInfluenza virus replicationInfluenza virusNeighboring cellsProtein 1Gap junctions