2024
Erectile Dysfunction in Adolescents and Young Adults
Pantazis A, Franco I, Gitlin J. Erectile Dysfunction in Adolescents and Young Adults. Current Urology Reports 2024, 25: 225-232. PMID: 38922362, DOI: 10.1007/s11934-024-01213-9.Peer-Reviewed Original ResearchConceptsPsychogenic etiologyCognitive behavioral therapyYoung adultsErectile dysfunctionBehavioral therapyPornography consumptionCortisol levelsAdolescent malesNormal testosterone levelsPediatric urology practiceAnxietyDepressionOnline pornography consumptionFindingsThe latest researchAdolescentsPediatric urologistsVascular resistanceUrological practiceTreatment recommendationsTestosterone levelsWork-upReviewThe goalDysfunctionAdultsErectileManagement of the refractory nocturnal enuresis patient to desmopressin in a pediatric population: Desmopressin + oxybutynin vs. desmopressin + imipramine
Shain S, Gitlin J, Pantazis A, Fine R, Horowitz M, Friedman S, Zelkovic P, Dyer L, Schlussel R, Freyle J, Fang A, Sommer J, Franco I. Management of the refractory nocturnal enuresis patient to desmopressin in a pediatric population: Desmopressin + oxybutynin vs. desmopressin + imipramine. Journal Of Pediatric Urology 2024, 20: 603.e1-603.e8. PMID: 38871547, DOI: 10.1016/j.jpurol.2024.05.024.Peer-Reviewed Original ResearchVancouver Symptom ScoreInternational Children's Continence SocietyWet nightsDesmopressin treatmentCombination therapyResponse rateIntent-to-treat response rateCombination therapy of desmopressinFirst-line medical therapyEfficacy of adjunctive therapyGroup IMPComplete response rateTreated with desmopressinCohort of patientsContinence successPrescribed desmopressinEnuresis patientsMedical therapyNighttime drynessChart reviewAdjunctive therapyConclusion A combinationDesmopressinOxybutyninPediatric populationSize matters: Total testicular volume predicts sperm count in Tanner V varicocele patients
Fang A, Franco I, Pizzuti J, Boroda J, Friedman S, Fine R, Horowitz M, Schlussel R, Landau-Dyer L, Zelkovic P, Freyle J, Sommer J, Gitlin J. Size matters: Total testicular volume predicts sperm count in Tanner V varicocele patients. Journal Of Pediatric Urology 2024, 20: 960-966. PMID: 38876892, DOI: 10.1016/j.jpurol.2024.05.012.Peer-Reviewed Original ResearchNegative predictive valueSemen analysisAbnormal SAPredictive valueSperm countSurgical interventionTesticular volumeRetrospective single-center chart reviewSingle-center chart reviewOdds ratioAppropriateness of surgical interventionLeft-sided varicoceleMotile sperm countAbnormal semen analysisReceiver operating characteristic analysisPrevalence of varicoceleMultivariate logistic regressionTotal testicular volumeYouden's J statisticVaricocele gradeMedian ageChart reviewUltrasound resultsYounger patientsRisk stratificationA comparison of 467 uroflowmetry results in repaired hypospadias vs. normal male flows
Boroda J, Gitlin J, Fang A, Zelkovic P, Reda E, Friedman S, Fine R, Horowitz M, Schlussel R, Landau-Dyer L, Freyle J, Franco I. A comparison of 467 uroflowmetry results in repaired hypospadias vs. normal male flows. Journal Of Pediatric Urology 2024, 20: 690.e1-690.e7. PMID: 38772843, DOI: 10.1016/j.jpurol.2024.04.017.Peer-Reviewed Original ResearchHypospadias repair surgeryRepair patientsUroflowmetry parametersRepair surgeryUroflowmetry studiesUroflowmetry resultsBinary logistic regressionMeatal stenosisUrethral strictureRepair groupStudy design Retrospective chart reviewLogistic regressionDesign Retrospective chart reviewDistal hypospadias casesObstructed urinary flowRetrospective chart reviewPresence of complicationsIdentification of complicationsObstructed urine flowPediatric nomogramsHypospadias patientsObstructive complicationsRepairing hypospadiasUrethral meatusHypospadias casesImmune checkpoint inhibitors in high‐grade upper tract urothelial carcinoma: Paradigm shift emphasizing organ preservation
Khalil M, Fishman A, Komorowski A, Franco I, Grasso M. Immune checkpoint inhibitors in high‐grade upper tract urothelial carcinoma: Paradigm shift emphasizing organ preservation. BJUI Compass 2024, 5: 490-496. PMID: 38751949, PMCID: PMC11090768, DOI: 10.1002/bco2.335.Peer-Reviewed Original ResearchImmune check point inhibitorsHigh-grade upper tract urothelial carcinomaUpper tract urothelial carcinomaMetastasis-free survival ratesGroup 2Group 1Survival rateUrothelial carcinomaSurvival outcomesMedian follow-up periodImpact of clinical characteristicsCheck-point inhibitorsImmune checkpoint inhibitorsEndoscopically treated patientsInitial tumor sizeImprove survival outcomesOverall survival rateKaplan-Meier analysisFollow-up periodImproved survival ratesCheckpoint inhibitorsPoint inhibitorsExtirpative surgeryTumor sizeClinical characteristics
2023
Changes in Autonomic Nervous System Activity in Children With Spina Bifida: A Case-Control Study
Kim B, Franco I, Lee Y, Han S, Kim S. Changes in Autonomic Nervous System Activity in Children With Spina Bifida: A Case-Control Study. International Neurourology Journal 2023, 27: 192-199. PMID: 37798886, PMCID: PMC10556434, DOI: 10.5213/inj.2346080.040.Peer-Reviewed Original ResearchHeart rate variability parametersControl groupSpina bifidaNN intervalsAutonomic nervous system dysfunctionAutonomic nervous system activityBladder filling phaseVideo-urodynamic studyNervous system dysfunctionCase-control studyNervous system activityR interval differencesLF/HF valuesVariability parametersSympathetic preponderanceNeurogenic bladderUrodynamic studiesSympathetic activityVesicoureteral refluxSystem dysfunctionParasympathetic activityPatientsSpina bifida groupBladderBifidaIs it time to reconsider how we document pediatric uroflow studies?: A study from the SPU Voiding Dysfunction task force
Van Batavia J, Pohl H, Farhat W, Chiang G, BaniHani A, Collett-Gardere T, Franco I. Is it time to reconsider how we document pediatric uroflow studies?: A study from the SPU Voiding Dysfunction task force. Journal Of Pediatric Urology 2023, 19: 546-554. PMID: 37302925, DOI: 10.1016/j.jpurol.2023.04.018.Peer-Reviewed Original ResearchInitial outcomes using a novel bedwetting alarm (Gogoband®) that utilizes real time artificial intelligence to wake users prior to wetting
Franco I, Coble J. Initial outcomes using a novel bedwetting alarm (Gogoband®) that utilizes real time artificial intelligence to wake users prior to wetting. Journal Of Pediatric Urology 2023, 19: 557.e1-557.e8. PMID: 37217414, DOI: 10.1016/j.jpurol.2023.04.024.Peer-Reviewed Original ResearchReply by Authors
Franco I, Hoebeke P, Dobremez E, Titanji W, Geib T, Jenkins B, Yushmanova I, Austin P. Reply by Authors. Journal Of Urology 2023, 209: 783-784. PMID: 36891836, DOI: 10.1097/ju.0000000000003157.03.Peer-Reviewed Original ResearchMP43-18 ADOLESCENT VARICOCELE: EFFECTS OF VEIN SIZE AND ARTERIAL FLOW RATE ON SEMINAL PARAMETERS
Ocal S, Sheikh A, Pizzuti J, Fang A, Boroda J, Friedman S, Fine R, Horowitz M, Fine R, Sclussel R, Dyer L, Zelkovic P, Freyle J, Franco I, Gitlin J. MP43-18 ADOLESCENT VARICOCELE: EFFECTS OF VEIN SIZE AND ARTERIAL FLOW RATE ON SEMINAL PARAMETERS. Journal Of Urology 2023, 209: e608. DOI: 10.1097/ju.0000000000003289.18.Peer-Reviewed Original ResearchMP70-01 MANAGEMENT OF THE REFRACTORY NOCTURNAL ENURESIS PATIENT TO DESMOPRESSIN IN A PEDIATRIC POPULATION: DESMOPRESSIN + OXYBUTYNIN VS. DESMOPRESSIN + IMIPRAMINE
Shain S, Gitlin J, Pantazis A, Fine R, Horowitz M, Friedman S, Zelkovic P, Dyer L, Schlussel R, Freyle J, Fang A, Sommer J, Franco I. MP70-01 MANAGEMENT OF THE REFRACTORY NOCTURNAL ENURESIS PATIENT TO DESMOPRESSIN IN A PEDIATRIC POPULATION: DESMOPRESSIN + OXYBUTYNIN VS. DESMOPRESSIN + IMIPRAMINE. Journal Of Urology 2023, 209: e1003. DOI: 10.1097/ju.0000000000003338.01.Peer-Reviewed Original ResearchLong-term Safety and Tolerability of Repeated Treatments With OnabotulinumtoxinA in Children With Neurogenic Detrusor Overactivity
Franco I, Hoebeke P, Dobremez E, Titanji W, Geib T, Jenkins B, Yushmanova I, Austin P. Long-term Safety and Tolerability of Repeated Treatments With OnabotulinumtoxinA in Children With Neurogenic Detrusor Overactivity. Journal Of Urology 2023, 209: 774-784. PMID: 36655470, DOI: 10.1097/ju.0000000000003157.Peer-Reviewed Original ResearchConceptsTreatment-emergent adverse eventsNeurogenic detrusor overactivityUrinary tract infectionAdverse eventsSingle-treatment studyDetrusor overactivityTract infectionsSafety profileCommon treatment-emergent adverse eventsSerious treatment-emergent adverse eventsUrinary tract infection rateSimilar safety profileClean intermittent catheterizationNew safety concernsLong-term safetyAutonomic dysreflexiaIntermittent catheterizationMedian durationOnabotulinumtoxinA treatmentDistant spreadDose groupPediatric dataRepeat treatmentRepeated TreatmentPatients
2022
Long-Term Safety and Tolerability of Repeated Treatments With OnabotulinumtoxinA in Children with Neurogenic Detrusor Overactivity
Franco I, Dobremez E, Hoebeke P, Titanji W, Yushmanova I, Jenkins B, Austin P. Long-Term Safety and Tolerability of Repeated Treatments With OnabotulinumtoxinA in Children with Neurogenic Detrusor Overactivity. Toxicon 2022, 214: s18-s19. DOI: 10.1016/j.toxicon.2021.11.049.Peer-Reviewed Original ResearchMP08-03 FLOW RATES AND FLOW INDEXES IN PEDIATRIC PATIENTS AFTER HYPOSPADIAS URETHROPLASTY: UROFLOW PARAMETERS IN 458 REPAIRED HYPOSPADIAC AND 1,081 NORMAL FLOWS
Boroda J, Zelkovic P, Fang A, Gitlin J, Franco I. MP08-03 FLOW RATES AND FLOW INDEXES IN PEDIATRIC PATIENTS AFTER HYPOSPADIAS URETHROPLASTY: UROFLOW PARAMETERS IN 458 REPAIRED HYPOSPADIAC AND 1,081 NORMAL FLOWS. Journal Of Urology 2022, 207: e125. DOI: 10.1097/ju.0000000000002530.03.Peer-Reviewed Original Research
2021
MP51-06 A CALL TO DISCONTINUE THE USE OF FLOW SHAPES IN PEDIATRIC UROFLOWMETRY
Van Batavia J, Pohl H, Farhat W, Chiang G, Hani A, Collett-Gardere T, Franco I. MP51-06 A CALL TO DISCONTINUE THE USE OF FLOW SHAPES IN PEDIATRIC UROFLOWMETRY. Journal Of Urology 2021, 206: e898-e898. DOI: 10.1097/ju.0000000000002077.06.Peer-Reviewed Original ResearchP1063 Long-term safety and tolerability of repeated treatments with onabotulinumtoxinA in children with neurogenic detrusor overactivity
Franco I, Dobremez E, Hoebeke P, Titanji W, Yushmanova I, Jenkins B, Austin P. P1063 Long-term safety and tolerability of repeated treatments with onabotulinumtoxinA in children with neurogenic detrusor overactivity. European Urology 2021, 79: s1506-s1507. DOI: 10.1016/s0302-2838(21)01435-4.Peer-Reviewed Original ResearchEfficacy and safety of three active doses of onabotulinumtoxinA for the treatment of neurogenic detrusor overactivity in children: Results of a randomized controlled clinical trial
Austin P, Franco I, Dobremez E, Kroll P, Titanji W, Geib T, Jenkins B, Hoebeke P. Efficacy and safety of three active doses of onabotulinumtoxinA for the treatment of neurogenic detrusor overactivity in children: Results of a randomized controlled clinical trial. Toxicon 2021, 190: s6. DOI: 10.1016/j.toxicon.2020.11.352.Peer-Reviewed Original Research
2020
Response to commentary ‘Magnetic resonance image connectivity analysis provides evidence of central nervous system mode of action for parasacral transcutaneous electro neural stimulation - A pilot study'
Franco I. Response to commentary ‘Magnetic resonance image connectivity analysis provides evidence of central nervous system mode of action for parasacral transcutaneous electro neural stimulation - A pilot study'. Journal Of Pediatric Urology 2020, 16: 544. PMID: 32928661, DOI: 10.1016/j.jpurol.2020.08.017.Peer-Reviewed Original ResearchMagnetic resonance image connectivity analysis provides evidence of central nervous system mode of action for parasacral transcutaneous electro neural stimulation - A pilot study
Netto JMB, Scheinost D, Onofrey JA, Franco I. Magnetic resonance image connectivity analysis provides evidence of central nervous system mode of action for parasacral transcutaneous electro neural stimulation - A pilot study. Journal Of Pediatric Urology 2020, 16: 536-542. PMID: 32873504, DOI: 10.1016/j.jpurol.2020.08.002.Peer-Reviewed Original ResearchConceptsDorsal lateral prefrontal cortexAnterior cingulate cortexOveractive bladderFunctional connectivityPrefrontal cortexUrinary tract symptomsSacral nerve stimulatorCommon treatment modalityRight scapular regionACC functional connectivityResting-state conditionsMechanism of actionTract symptomsMotor thresholdCentral effectsACC connectivityNerve stimulatorSacral levelTreatment modalitiesFunctional connectivity dataMechanism of effectivenessAdult volunteersFrontal lobeSubcortical regionsCingulate cortex751 Efficacy and safety of three active doses of onabotulinum toxin A for the treatment of neurogenic detrusor overactivity in children: Results of a randomized controlled clinical trial
Hoebeke P, Austin P, Franco I, Dobremez E, Kroll P, Titanji W, Geib T, Jenkins B. 751 Efficacy and safety of three active doses of onabotulinum toxin A for the treatment of neurogenic detrusor overactivity in children: Results of a randomized controlled clinical trial. European Urology Open Science 2020, 19: e1147. DOI: 10.1016/s2666-1683(20)33351-6.Peer-Reviewed Original Research