Daniel Robert Rubio, MD, FACS, FAAOS
Assistant Professor of OrthopaedicsCards
About
Research
Publications
2024
Perioperative inpatient falls for anterior cervical discectomy and fusion patients are on the rise: Risk factors associated with this “never event”
Seddio A, Jabbouri S, Gouzoulis M, Vasudevan R, Halperin S, Varthi A, Rubio D, Grauer J. Perioperative inpatient falls for anterior cervical discectomy and fusion patients are on the rise: Risk factors associated with this “never event”. The Spine Journal 2024 PMID: 39631462, DOI: 10.1016/j.spinee.2024.11.018.Peer-Reviewed Original ResearchInpatient fallsLength of stayMultivariate logistic regressionAnterior cervical discectomyInpatient ACDFElixhauser Comorbidity IndexMultidisciplinary fall prevention programAnnual incidenceRisk factorsInpatient fall preventionFall prevention programsLogistic regressionNational sample of patientsCervical discectomyNational Quality ForumSocioeconomically disadvantaged patientsHistory of dementiaUnderweight body mass indexACDF patientsObese BMI >Posterior cervical proceduresBody mass indexMulti-level ACDFAdult patientsQuality ForumThe incidence, providers involved, and patient factors associated with diagnosis of specific lumbar spine pathology subsequent an initial nonspecific low back pain diagnosis
Seddio A, Jabbouri S, Gouzoulis M, Sanchez J, Day W, Varthi A, Rubio D, Grauer J. The incidence, providers involved, and patient factors associated with diagnosis of specific lumbar spine pathology subsequent an initial nonspecific low back pain diagnosis. The Spine Journal 2024 PMID: 39505011, DOI: 10.1016/j.spinee.2024.10.008.Peer-Reviewed Original ResearchLow back painPrimary care providersLow back pain diagnosisNS-LBPInternational Classification of DiseasesLumbar spine pathologyHistory of cancerSpecialty providersOpioid use disorderNonspecific low back painSpine pathologyBack pain diagnosisPCP providersFactors associated with diagnosisClassification of DiseasesUse disorderLBP managementLBP symptomsNational administrative databaseCare providersBack painFamily medicineAdult patientsProvider specialtyPain diagnosisSemaglutide utilization associated with reduced ninety-day postoperative complications following single-level posterior lumbar fusion for patients with type II diabetes
Seddio A, Gouzoulis M, Vasudevan R, Dhodapkar M, Jabbouri S, Varthi A, Rubio D, Grauer J. Semaglutide utilization associated with reduced ninety-day postoperative complications following single-level posterior lumbar fusion for patients with type II diabetes. The Spine Journal 2024 PMID: 39491749, DOI: 10.1016/j.spinee.2024.10.011.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionSodium-glucose transport protein 2 inhibitorsAdverse eventsPostoperative complicationsT2DM patientsCurrent Procedural TerminologyElixhauser Comorbidity IndexED visitsLumbar fusionHospital readmissionEmergency departmentOdds of postoperative complicationsNinety-day postoperative complicationsImpact of semaglutideOdds of hospital readmissionMonths of surgeryRetrospective cohort studyPostoperative adverse eventsMinor adverse eventsType II diabetes mellitusRisk of type I errorDiagnosis of T2DMII diabetes mellitusYears of ageInflammatory bowel disease is associated with greater odds of complications following posterior lumbar fusion and further amplified for patients exposed to biologics
Seddio A, Katsnelson B, Smith-Voudouris J, Gouzoulis M, Day W, Jabbouri S, Vasudevan R, Rubio D, Grauer J. Inflammatory bowel disease is associated with greater odds of complications following posterior lumbar fusion and further amplified for patients exposed to biologics. North American Spine Society Journal (NASSJ) 2024, 100574. DOI: 10.1016/j.xnsj.2024.100574.Peer-Reviewed Original ResearchPosterior lumbar fusionInflammatory bowel diseaseOdds ratioNational Inpatient SampleElixhauser Comorbidity IndexLumbar fusionBowel diseaseKaplan-Meier survival analysisEmergency departmentInflammatory bowel disease patientsLog-rank testMinor adverse eventsNon-IBD patientsIn-hospital dataMultivariate logistic regressionAssociated with greater oddsElevated odds ratiosReoperation rateSurgical complicationsSpine surgeryInferior outcomesPearlDiver databasePost-discharge outcomesAdult patientsAdverse eventsComparable Overall Risk of Neurologic Adverse Events Following Cervicothoracic Interlaminar and Transforaminal Epidural Injections: An Analysis of 1.29 Million Patients.
Seddio A, McNamara K, Gouzoulis M, Jabbouri S, Vasudevan R, Day W, Ratnasamy P, Rubio D, Grauer J. Comparable Overall Risk of Neurologic Adverse Events Following Cervicothoracic Interlaminar and Transforaminal Epidural Injections: An Analysis of 1.29 Million Patients. Spine 2024 PMID: 39394649, DOI: 10.1097/brs.0000000000005181.Peer-Reviewed Original ResearchNeurological adverse eventsAdverse eventsElixhauser Comorbidity IndexNeurological complicationsOdds ratioEpidural spinal injectionsInterlaminar (ILTransforaminal epidural injectionsAssociated with specific complicationsTransforaminal (TFNerve root injuryRisk of complicationsAssociated with higher odds ratiosMultivariate logistic regressionRisk of neurological adverse eventsHigher odds ratioCervical pathologyEpidural hematomaTF injectionSpinal injectionEpidural injectionSpecific complicationsAdult patientsCase reportComorbidity indexP27. Renal transplant patients at increased odds off many perioperative adverse events following lumbar laminotomy/discectomy
Gouzoulis M, Seddio A, Zhu J, Day W, Jabbouri S, Rubio D, Grauer J. P27. Renal transplant patients at increased odds off many perioperative adverse events following lumbar laminotomy/discectomy. The Spine Journal 2024, 24: s76. DOI: 10.1016/j.spinee.2024.06.048.Peer-Reviewed Original ResearchSevere adverse eventsHistory of renal transplantationUrinary tract infectionRenal transplantationAcute kidney injuryAdverse eventsMinor adverse eventsElixhauser Comorbidity IndexIncreased oddsCurrent Procedural TerminologyTract infectionsLumbar discectomyKidney injuryED visitsIncreased odds of acute kidney injuryOdds of acute kidney injuryOdds ratioOdds of ED visitsKaplan-Meier survival curvesDays of follow-upRenal transplant groupRenal transplant patientsIncidence of reoperationRisk of reoperationOdds of sepsisP31. Testosterone replacement therapy associated with increased 90-day postoperative adverse events and 5-year reoperation following lumbar discectomy
Seddio A, Gouzoulis M, Smith-Voudouris J, Rubio D, Day W, Grauer J. P31. Testosterone replacement therapy associated with increased 90-day postoperative adverse events and 5-year reoperation following lumbar discectomy. The Spine Journal 2024, 24: s78. DOI: 10.1016/j.spinee.2024.06.052.Peer-Reviewed Original ResearchTestosterone replacement therapyAcute kidney injuryLumbar discectomyAdverse eventsMale patientsOdds ratioCurrent Procedural TerminologyReoperation ratePostoperative outcomesElixhauser Comorbidity IndexPostoperative recoveryMultivariate analysisSingle-level lumbar discectomyTestosterone replacement therapy patientsMyocardial infarctionOrthopedic surgeryKaplan-Meier survival analysisEmergency departmentLumbar spinal proceduresLog-rank testMonths of surgeryRetrospective cohort studyPostoperative adverse eventsEnhanced postoperative recoveryMinor adverse events35. Comparable risk of adverse events following cervicothoracic interlaminar and transforaminal epidural injections: an analysis of 1.29 million patients
Seddio A, McNamara K, Gouzoulis M, Jabbouri S, Ratnasamy P, Rubio D, Grauer J. 35. Comparable risk of adverse events following cervicothoracic interlaminar and transforaminal epidural injections: an analysis of 1.29 million patients. The Spine Journal 2024, 24: s19. DOI: 10.1016/j.spinee.2024.06.478.Peer-Reviewed Original ResearchAdverse eventsSpinal neurologic deficitsStatistically significant differenceCurrent Procedural TerminologyElixhauser Comorbidity IndexEpidural injectionAdult patientsNeurological deficitsAdverse outcomesMultivariate analysisED visitsIncidence of adverse eventsEpidural spinal injectionsTransforaminal epidural injectionsEmergency departmentTransforaminal (TFRisk of adverse eventsSignificant differenceRetrospective cohort studyMinor adverse eventsSampled adult patientsOutcome measures IncidencePotential adverse eventsSpinal injectionPatient age100. Semaglutide associated with improved postoperative outcomes following single-level posterior lumbar fusion for patients with type II diabetes
Seddio A, Gouzoulis M, Vasudevan R, Dhodapkar M, Jabbouri S, Zhu J, Rubio D, Grauer J. 100. Semaglutide associated with improved postoperative outcomes following single-level posterior lumbar fusion for patients with type II diabetes. The Spine Journal 2024, 24: s52-s53. DOI: 10.1016/j.spinee.2024.06.543.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionSodium-glucose transport protein 2 inhibitorsImpact of semaglutideHospital readmissionPostoperative outcomesElixhauser Comorbidity IndexED visitsT2DM patientsCurrent Procedural TerminologyEmergency departmentLumbar fusionAdverse eventsOdds of hospital readmissionOutcome measures IncidenceRisk of type I errorInferior postoperative outcomesDiagnosis of T2DMMonths of surgeryYear of surgeryRetrospective cohort studyMinor adverse eventsType II diabetes mellitusMatched 1:4Management of diabetesTrends in management of odontoid fractures 2010–2021
Gouzoulis M, Seddio A, Rancu A, Jabbouri S, Moran J, Varthi A, Rubio D, Grauer J. Trends in management of odontoid fractures 2010–2021. North American Spine Society Journal (NASSJ) 2024, 20: 100553. PMID: 39381260, PMCID: PMC11459689, DOI: 10.1016/j.xnsj.2024.100553.Peer-Reviewed Original ResearchOdontoid fracturesSurgical interventionPredictive factorsAdult patientsManagement of odontoid fracturesPosterior stabilizationMethods Adult patientsNon-clinical factorsRate of surgerySampled adult patientsYearly rateAnterior surgeryPosterior surgeryNonoperative careSurgical managementNonsurgical treatmentClinical factorsMale sexPosterior approachMultivariate analysisMedicare insuranceFracture managementSurgeryPatientsMidwest United States
Academic Achievements & Community Involvement
Clinical Care
Overview
Daniel Rubio, MD, is a board-certified, fellowship-trained orthopaedic spine surgeon and assistant professor of orthopaedic surgery at Yale School of Medicine. He is co-medical director of the Spine Center at Yale New Haven Hospital and associate vice chair of clinical affairs in the Department of Orthopaedics at Yale School of Medicine.
He specializes in treating conditions of the neck and back, including spinal deformity, spine tumors and metastatic disease, spine trauma, infections of the spine, and degenerative conditions. He treats both adult and pediatric patients.
He received his Medical Doctorate from Drexel University where he graduated Alpha Omega Alpha. He completed Residency in Orthopaedic Surgery at Yale University School of Medicine and Fellowship in Combined Neurosurgery/Orthopaedic Spine Surgery at Washington University in Saint Louis. He also completed the AO North America Spine Fellowship.
Dr. Rubio is actively involved in both clinical and basic science research. He holds a patent for a novel diagnostic test for neurodegenerative diseases, and has published research on various orthopaedic and spine conditions with an emphasis on optimizing patient outcomes. His research and that of his collaborators have been presented at regional, national, and international conferences. He teaches students and residents at Yale School of Medicine.
Dr. Rubio believes in a patient-centered approach to care including both surgical and non-surgical means to return his patients to a pain-free and active lifestyle. He sees patients at the Yale Spine Center (New Haven) and the Guilford Orthopaedic Surgery office location. He performs surgery at both Yale New Haven Hospital (York St.) and Yale-Saint Raphael Campus.
Clinical Specialties
Spine Surgery; Orthopaedics & Rehabilitation
Fact Sheets
Spinal Deformity
Learn More on Yale MedicineMinimally Invasive Spinal Surgery
Learn More on Yale MedicineMinimally Invasive Surgery
Learn More on Yale MedicineRobot-Assisted Heart Surgery
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Board Certifications
Orthopaedic Surgery
- Certification Organization
- AB of Orthopaedic Surgery
- Original Certification Date
- 2022
Yale Medicine News
News
News
- February 27, 2023Source: NBC Connecticut
Yale Doctors Explain How to Avoid Top Winter Injuries
- February 15, 2023Source: Yale Medicine
Compression Fractures, Strains, and Falls: How to Prevent Winter Back Injuries
- May 11, 2022
New Spine Robot to Serve as Backbone for Orthopaedic Innovations in Personalized Medicine
- August 05, 2021Source: Yale Medicine
Back Pain: Bad Posture or a Different Problem?