Xinran Liu, MD, PhD
Senior Research ScientistDownloadHi-Res Photo
Cards
Appointments
Neuroscience
Primary
Additional Titles
Director of CCMI Electron Microscopy Core Facility, Center for Cellular and Molecular Imaging
Contact Info
Center for Cellular and Molecular Imaging
333 Cedar Street
New Haven, CT 06510
United States
Appointments
Neuroscience
Primary
Additional Titles
Director of CCMI Electron Microscopy Core Facility, Center for Cellular and Molecular Imaging
Contact Info
Center for Cellular and Molecular Imaging
333 Cedar Street
New Haven, CT 06510
United States
Appointments
Neuroscience
Primary
Additional Titles
Director of CCMI Electron Microscopy Core Facility, Center for Cellular and Molecular Imaging
Contact Info
Center for Cellular and Molecular Imaging
333 Cedar Street
New Haven, CT 06510
United States
About
Titles
Senior Research Scientist
Director of CCMI Electron Microscopy Core Facility, Center for Cellular and Molecular Imaging
Appointments
Neuroscience
Senior Research ScientistPrimary
Other Departments & Organizations
- Center for Cellular and Molecular Imaging
- Electron Microscopy
- Neuroscience
Education & Training
- Post doctoral training
- University of California San Diego (2000)
- PhD
- Nagoya University School of Medicine (1996)
- MD
- Shanghai Second Military Medical University (1985)
Research
Overview
As one of the core facilities in the Medical School, We offer a wide range of services from conventional and immuno- electron microscopy to electron tomography. Our experienced staff routinely perform sample processing, sectioning and imaging for a set fee. Our facility is open to users who have had prior training in electron microscopy. The training on use of electron microscope and sample preparation is provided on a one-on-one basis throughout the year.
ORCID
0000-0002-1586-2151- View Lab Website
CCMI Electron Microscopy Core Facility
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xinran Liu's published research.
Publications Timeline
A big-picture view of Xinran Liu's research output by year.
Peter Cresswell, PhD, FRS
Christopher Bunick, MD/PhD
Jain Jeong, PhD
Jennifer McNiff, MD
Joao Pereira, PhD
Keith Choate, MD, PhD
13Publications
946Citations
Publications
2024
Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features
Yang Y, Jeong J, Su T, Lai S, Zhang P, Garcia-Milian R, Graham M, Liu X, McConnell M, Utsumi T, Pereira J, Iwakiri Y. Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features. JHEP Reports 2024, 6: 101069. PMID: 38966234, PMCID: PMC11222939, DOI: 10.1016/j.jhepr.2024.101069.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCell surface structuresLymphatic endothelial cellsPublished single-cell RNA-sequencingRNA-seq analysisScRNA-seq analysisSingle-cell RNA sequencingLymphatic systemEndothelial cellsInterleukin-7RNA-seqScRNA-seqExpressed genesRNA sequencingTranscriptomic changesLow abundanceI/R liver injuryGenesIsolation protocolLiver cell typesCell typesIsolation methodLiver of miceHuman liver specimensHeterozygous miceMouse liverCutting Edge: Phagosome-associated Autophagosomes Containing Antigens and Proteasomes Drive TAP-Independent Cross-Presentation.
Sengupta D, Galicia-Pereyra R, Han P, Graham M, Liu X, Arshad N, Cresswell P. Cutting Edge: Phagosome-associated Autophagosomes Containing Antigens and Proteasomes Drive TAP-Independent Cross-Presentation. The Journal Of Immunology 2024, 212: 1063-1068. PMID: 38353614, PMCID: PMC10948299, DOI: 10.4049/jimmunol.2200446.Peer-Reviewed Original ResearchConceptsCross-presentationTransporter associated with Ag processingExogenous AgCD8-positive T lymphocytesAntigenic peptidesMHC-I moleculesDendritic cellsProteasomal deliveryT lymphocytesCytosolic proteasomeActive proteasomesEndocytic compartmentsTAP-independentLumen of phagosomesSubcellular compartmentsEndoplasmic reticulumEndolysosomal vesiclesMHC-IAg processingBind to MHC-IProteasome
2022
Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with in situ hybridization and electron microscopy findings
Roy S, Sarhan J, Liu X, Murphy M, Bunick C, Choate K, Damsky W, McNiff J. Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with in situ hybridization and electron microscopy findings. British Journal Of Dermatology 2022, 188: 574-576. PMID: 36763786, DOI: 10.1093/bjd/ljac146.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVirus infectionUnusual clinical findingsElectron microscopy findingsEccrine epitheliumSquamous syringometaplasiaClinical findingsSitu hybridizationEccrine ductsMicroscopy findingsSyringometaplasiaUltrastructural characteristicsInfectionViral mRNAsFindingsPatientsHistopathologicalDiseaseEpitheliumProteasomal degradation within endocytic organelles can mediate antigen cross- presentation
Sengupta D, Graham M, Liu X, Cresswell P. Proteasomal degradation within endocytic organelles can mediate antigen cross- presentation. Molecular Immunology 2022, 150: 23. DOI: 10.1016/j.molimm.2022.05.080.Peer-Reviewed Original ResearchConceptsDendritic cellsMHC-I moleculesMouse bone marrow-derived dendritic cellsBone marrow-derived dendritic cellsMarrow-derived dendritic cellsAntigen processingConventional antigen processingMouse dendritic cellsMHC-I-peptide complexesSurface MHCMHCSurface expressionProteasome inhibitionPeptide loadingHuman B2Cell phagosomesCell typesActive proteasomesSpecific peptidesCellsPeptidesEndocytic compartmentsProteasomal degradationEndocytic pathwayRetro-2 alters Golgi structure
Yue X, Gim B, Zhu L, Tan C, Qian Y, Graham M, Liu X, Lee I. Retro-2 alters Golgi structure. Scientific Reports 2022, 12: 14975. PMID: 36056100, PMCID: PMC9438350, DOI: 10.1038/s41598-022-19415-x.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsRetro-2Golgi apparatusGolgi structureER exit site proteinGolgi structural proteinsGolgi stacksER exitGolgi organizationIndividual cisternaeGolgiStructural proteinsProtein secretionPerinuclear areaUltra-structural studiesEM tomographyVesicular profilesHuman lung cellsPartial disassemblySyntaxin5ProteinCultured human lung cellsCell depletionDisassemblyUltrastructureCells
2019
Parasite‐Derived Vesicular‐Mediated Protein Export by the Human Pathogen Babesia microti
Mamoun C, Thekkiniath J, Kilian N, Lawres L, Gewirtz M, Abraham A, Graham M, Liu X, Ledizet M. Parasite‐Derived Vesicular‐Mediated Protein Export by the Human Pathogen Babesia microti. The FASEB Journal 2019, 33: 649.2-649.2. DOI: 10.1096/fasebj.2019.33.1_supplement.649.2.Peer-Reviewed Original ResearchCitationsConceptsMajor morphogenetic changesImmunoelectron microscopy analysisB. microtiProtein exportPhylum ApicomplexaMorphogenetic changesSecreted proteinsCell fractionationIntraerythrocytic developmentCanonical motifsExport systemPlasma membraneErythrocyte cytoplasmMajor immunodominant antigenBabesia microtiParasitophorous vacuoleHost erythrocyteWorldwide geographic distributionMalaria-like illnessGeographic distributionMalaria parasitesCell environmentProteinFASEB JournalFull-text articles
2014
Membrane adhesion dictates Golgi stacking and cisternal morphology
Lee I, Tiwari N, Dunlop MH, Graham M, Liu X, Rothman JE. Membrane adhesion dictates Golgi stacking and cisternal morphology. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 1849-1854. PMID: 24449908, PMCID: PMC3918774, DOI: 10.1073/pnas.1323895111.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFK506-binding protein (FKBP) domainsGolgi cisternaeGolgi matrix proteinsClass of proteinsCisternal morphologyCisternal maturationProtein domainsGolgi membranesGolgi stacksRegulatory proteinsGolgiMatrix proteinsMembrane adhesionMembrane transportProtein 55Adhesive processHeLa cellsAdhesive proteinsProteinGolginsCargo transportAncient formCisternaeQuantitative electron microscopyMitochondriaA dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis
Wu Y, O'Toole ET, Girard M, Ritter B, Messa M, Liu X, McPherson PS, Ferguson SM, De Camilli P. A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. ELife 2014, 3: e01621. PMID: 24963135, PMCID: PMC4107917, DOI: 10.7554/elife.01621.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsClathrin-mediated endocytosisDynamin 1Bulk endosomesBulk endocytosisSynaptic vesiclesNew synaptic vesiclesClathrin-independent pathwaySynaptic vesicle recyclingSV membranesSV reformationDynamin 3Vesicle recyclingClathrinEndocytosisLarge endocytic vacuolesEndocytic vacuolesEndosomesPotent stimulationIntense synaptic activityVacuolesPathwaySynaptic activityMassive formationExocytosisBuds
2013
Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm
Yoo S, Mohawk J, Siepka S, Shan Y, Huh S, Hong H, Kornblum I, Kumar V, Koike N, Xu M, Nussbaum J, Liu X, Chen Z, Chen Z, Green C, Takahashi J. Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm. Cell 2013, 152: 1091-1105. PMID: 23452855, PMCID: PMC3694781, DOI: 10.1016/j.cell.2013.01.055.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsE3 ligase complexLigase complexSCF E3 ligase complexF-box protein genesCircadian periodE3 ligase activityMammalian circadian clockCry proteinsUbiquitin ligasesE3 ligasesCRY degradationLoss of functionCircadian mutantsLigase activityProtein geneCellular compartmentalizationCircadian clockFBXL21FBXL3Missense mutationsLigasesCytoplasmDual roleMutationsTurnover rate
2012
Nuclear localization of Klotho in brain: an anti-aging protein
German D, Khobahy I, Pastor J, Kuro-o M, Liu X. Nuclear localization of Klotho in brain: an anti-aging protein. Neurobiology Of Aging 2012, 33: 1483.e25-1483.e30. PMID: 22245317, PMCID: PMC3328593, DOI: 10.1016/j.neurobiolaging.2011.12.018.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExtracellular domainNuclear membraneSingle-pass transmembrane proteinMultiple fibroblast growth factor receptorsFibroblast growth factor receptorNuclear functionsPrecise cellular localizationTransmembrane proteinGrowth factor receptorNuclear localizationPlasma membraneTransmembrane formCellular localizationCell typesCultured cellsAnti-aging proteinCell membraneImmunoelectron microscopyLigand affinityWhole animalFactor receptorAntioxidant enzymesProteinKlotho proteinGenes
News & Links
Media
News
- January 17, 2022
Newly Recruited Scientists Bring Innovative Imaging Technology to YSM
- April 01, 2021
Insulin Stimulates Production of Body Heat, New Study Finds
- March 07, 2021Source: Nature Metabolism
A new mechanism by which insulin regulates the production of body heat
- June 19, 2019
How an Emerging Tick-borne Pathogen Evades Detection
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Center for Cellular and Molecular Imaging
333 Cedar Street
New Haven, CT 06510
United States