Eric Winer, MD
Alfred Gilman Professor of Pharmacology and Professor of Medicine (Medical Oncology)Cards
Administrative Support
Publications Overview
- 1,011 Publications
- 16,652 Citations
- 22 Yale Co-Authors
Additional Titles
Director, Yale Cancer Center
President and Physician-in-Chief, Smilow Cancer Hospital
Deputy Dean for Cancer Research, Yale School of Medicine
Administrative Support
Publications Overview
- 1,011 Publications
- 16,652 Citations
- 22 Yale Co-Authors
Additional Titles
Director, Yale Cancer Center
President and Physician-in-Chief, Smilow Cancer Hospital
Deputy Dean for Cancer Research, Yale School of Medicine
Administrative Support
Publications Overview
- 1,011 Publications
- 16,652 Citations
- 22 Yale Co-Authors
About
Titles
Alfred Gilman Professor of Pharmacology and Professor of Medicine (Medical Oncology)
Director, Yale Cancer Center; President and Physician-in-Chief, Smilow Cancer Hospital; Deputy Dean for Cancer Research, Yale School of Medicine
Biography
Dr. Eric Winer was appointed Director of Yale Cancer Center and President and Physician-in-Chief of Smilow Cancer Hospital Yale New Haven Health System on February 1, 2022. He is also the Alfred Gilman Professor of Medicine and Pharmacology and Deputy Dean of Cancer Research at Yale School of Medicine. An internationally renowned expert in breast cancer, Dr. Winer has led and collaborated on innumerable clinical trials that have changed the face of the disease. His work has touched almost all aspects of breast cancer and he is particularly well known for his work in HER2 positive disease. Dr. Winer has long been an advocate of building teams consisting of scientists and clinicians to accelerate progress in cancer research and care. He previously served as principal investigator of a breast cancer Specialized Program of Research Excellence (SPORE) for over a decade.
Dr. Winer is a member of the Board for the American Society of Clinical Oncology (ASCO) and a member of the Scientific Advisory Board of the Breast Cancer Research Foundation. For over a decade, he served as chief scientific advisor and chair of the Scientific Advisory Board for Susan G. Komen for the Cure. He co-led the National Cancer Institute Breast Cancer Steering Committee from 2016-2022. Dr. Winer has published over 400 original manuscripts and mentored over 30 fellows and junior faculty. In recognition of his mentoring impact, he was the recipient of the William Silen Lifetime Achievement in Mentoring Award from Harvard Medical School in 2020. He has also received numerous awards for his breast cancer research, most notably the William L. McGuire Memorial Lecture Award in 2016 at the San Antonio Breast Cancer Symposium, the Gianni Bonadonna Breast Cancer Award at ASCO in 2017, the Susan G. Komen Brinker Award for Clinical Research in 2018, and the Jill Rose award from the Breast Cancer Research Foundation in 2019.
Dr. Winer is an alumnus of both Yale College and Yale School of Medicine. After receiving his medical degree in 1983, he completed training in internal medicine and served as chief resident at Yale New Haven Hospital. He completed a fellowship in hematology/oncology at Duke University School of Medicine and served on the Duke faculty from 1989 to 1997. He then joined Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and Harvard Medical School where he built an internationally prominent breast cancer program. Prior to his move back to Yale in 2022, he held the Thompson Chair in Breast Cancer Research and served as chief clinical development officer, and senior vice president for medical affairs at Dana-Farber Cancer Institute, as well as Professor of Medicine at Harvard Medical School.
Appointments
Medical Oncology
ChairDualMedical Oncology
ProfessorPrimary
Other Departments & Organizations
- Center for Breast Cancer
- Developmental Therapeutics
- Internal Medicine
- Medical Oncology
- Subset Medical Oncology Faculty
- Yale Biomedical Imaging Institute
- Yale Cancer Center
- Yale Medicine
Education & Training
- Chief Resident
- Yale School of Medicine (1987)
- Resident
- Yale School of Medicine
- Intern
- Yale School of Medicine (1984)
- MD
- Yale School of Medicine
Research
Overview
Over the past decade, I have focused on developing new therapies for women with breast cancer and directed more of my attention to basic and translational research. I have secured peer-reviewed funding from the Avon Partners for Progress Program, the Komen Foundation, and the Breast Cancer Research Program.
Medical Research Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Ian Krop, MD, PhD
Melinda Irwin, PhD, MPH
Mehra Golshan, MD, MBA
Michael DiGiovanna, MD, PhD
Tara Sanft, MD
Brenda Cartmel, PhD
Publications
2024
A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
Klughammer J, Abravanel D, Segerstolpe Å, Blosser T, Goltsev Y, Cui Y, Goodwin D, Sinha A, Ashenberg O, Slyper M, Vigneau S, Jané‐Valbuena J, Alon S, Caraccio C, Chen J, Cohen O, Cullen N, DelloStritto L, Dionne D, Files J, Frangieh A, Helvie K, Hughes M, Inga S, Kanodia A, Lako A, MacKichan C, Mages S, Moriel N, Murray E, Napolitano S, Nguyen K, Nitzan M, Ortiz R, Patel M, Pfaff K, Porter C, Rotem A, Strauss S, Strasser R, Thorner A, Turner M, Wakiro I, Waldman J, Wu J, Gómez Tejeda Zañudo J, Zhang D, Lin N, Tolaney S, Winer E, Boyden E, Chen F, Nolan G, Rodig S, Zhuang X, Rozenblatt-Rosen O, Johnson B, Regev A, Wagle N. A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features. Nature Medicine 2024, 30: 3236-3249. PMID: 39478111, PMCID: PMC11564109, DOI: 10.1038/s41591-024-03215-z.Peer-Reviewed Original ResearchConceptsClinicopathological featuresLocal T cell infiltrationT cell infiltrationMetastatic breast cancerBreast cancer biopsiesCancer-related deathsEpithelial-to-mesenchymal transitionMetastatic diseaseClinically relevant discoveriesTumor biopsiesTumor microenvironmentCancer biopsiesBreast cancerAnatomical sitesMacrophage populationsSingle-nucleus RNA sequencingBiopsyH&E stainingConsecutive serial sectionsClinical annotationTumorSingle-cellSpatial expression characteristicsSerial sectionsCell type compositionPatient-reported outcomes, and perceptions and knowledge about recurrence in women with hormone receptor-positive breast cancer
Rosenberg S, Zheng Y, Santos K, Riley E, Meadows H, Snow C, Hughes M, Frank E, Lin N, Partridge A, Winer E, Parsons H. Patient-reported outcomes, and perceptions and knowledge about recurrence in women with hormone receptor-positive breast cancer. Breast Cancer Research And Treatment 2024, 1-8. PMID: 39432162, DOI: 10.1007/s10549-024-07510-8.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsEmotional healthBreast cancer risk perceptionBreast cancerCancer risk perceptionCollege degreeInaccurate risk perceptionsHR+ breast cancerLower educational attainmentPatient-reported outcomesRecurrence riskBreast cancer recurrenceRisk perceptionAssociated with overestimationCancer survivorsImprove risk communicationPROMIS AnxietyPopulation normsHormone receptor-positive breast cancerSurveyed patientsReceptor-positive breast cancerGeneral populationRisk overestimationYears post-treatmentLogistic regressionHypofractionated vs Conventionally Fractionated Postmastectomy Radiation After Implant-Based Reconstruction
Wong J, Uno H, Tramontano A, Fisher L, Pellegrini C, Abel G, Burstein H, Chun Y, King T, Schrag D, Winer E, Bellon J, Cheney M, Hardenbergh P, Ho A, Horst K, Kim J, Leonard K, Moran M, Park C, Recht A, Soto D, Shiloh R, Stinson S, Snyder K, Taghian A, Warren L, Wright J, Punglia R. Hypofractionated vs Conventionally Fractionated Postmastectomy Radiation After Implant-Based Reconstruction. JAMA Oncology 2024, 10: 1370-1378. PMID: 39115975, PMCID: PMC11310844, DOI: 10.1001/jamaoncol.2024.2652.Peer-Reviewed Original ResearchConceptsFunctional Assessment of Cancer Therapy-BreastPhysical well-beingPostmastectomy radiation therapyImplant-based reconstructionConventional fractionationStudy armsPhysical well-being scoresUS cancer centersLocal-regional disease controlImprove quality of lifeQuality of lifeAs-treated cohortChest wall doseHigher adverse eventsToxic effectsMain OutcomesRandomized clinical trialsPWB scoreUnpaid timePostmastectomy radiationImplant reconstructionRadiation therapyTreatment breaksImplant-basedImprovement changesAssociation between mammographic screening history and stage at diagnosis among women with screen-detected breast cancer.
Huang S, Westvold S, Soulos P, Winer E, Robinson T, Dinan M. Association between mammographic screening history and stage at diagnosis among women with screen-detected breast cancer. Journal Of Clinical Oncology 2024, 20: 145-145. DOI: 10.1200/op.2024.20.10_suppl.145.Peer-Reviewed Original ResearchConceptsScreen-detected breast cancerBreast cancer mortalityScreening historyScreening mammographyScreening mammogramsCancer mortalityFee-for-service Medicare Parts ABreast cancerBreast cancer-specific mortalityScreening prior to diagnosisNon-Hispanic black raceNegative screening mammogramCohort study of womenFactors associated with increased oddsAssociated with lower riskRetrospective cohort study of womenRoutine screening mammographyMedicare Part AHigh school educationStudy of womenCancer-specific mortalityMultivariate logistic regressionSEER-Medicare databaseClaims-based algorithmSporadic screeningAdjuvant Pertuzumab and Trastuzumab in Early Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer in the APHINITY Trial: Third Interim Overall Survival Analysis With Efficacy Update
Loibl S, Jassem J, Sonnenblick A, Parlier D, Winer E, Bergh J, Gelber R, Restuccia E, Im Y, Huang C, Dalenc F, Calvo I, Procter M, Caballero C, Clark E, Raimbault A, McConnell R, Monturus E, de Azambuja E, Gomez H, Bliss J, Viale G, Bines J, Piccart M, Aebi S, Andersson M, Bergh J, Bines J, Bliss J, Bonnefoi H, Caballero C, Cameron D, Cardoso F, Clark E, de Azambuja E, de Haas S, Dent S, Fein L, Frank E, Gelber R, Gnant M, Gomez Moreno H, Im S, Jackisch C, Janni W, Jassem J, Krop I, Kümmel S, Liu T, Loi S, Loibl S, Masuda N, Nili Gam-Yal E, Nyawira B, Pascual T, Piccart M, Pienkowski T, Procter M, Restuccia E, Rodríguez-Lescure Á, Suter T, Thomssen C, Tjan-Heijnen V, Tomasello G, Torres Ulloa M, Twelves C, Viale G, Walshe J, Wilcken N, Winer E. Adjuvant Pertuzumab and Trastuzumab in Early Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer in the APHINITY Trial: Third Interim Overall Survival Analysis With Efficacy Update. Journal Of Clinical Oncology 2024, 42: 3643-3651. PMID: 39259927, DOI: 10.1200/jco.23.02505.Peer-Reviewed Original ResearchConceptsInvasive disease-free survivalNode-negative cohortNode-positive cohortOverall survivalBreast cancerAPHINITY trialHuman epidermal growth factor receptor 2-positiveEpidermal growth factor receptor 2-positiveInvasive disease-free survival benefitHER2+) breast cancerHuman epidermal growth factor receptor 2-positive breast cancerInterim overall survival analysisYears of median follow-upIntent-to-treat populationInterim analysisHormone receptor-negativeDisease-free survivalMedian follow-upPrimary end pointOverall survival analysisAdjuvant pertuzumabAdjuvant trastuzumabReceptor-negativePlacebo groupClinical trial updateA Phase II Study of Atezolizumab, Pertuzumab, and High-Dose Trastuzumab for Central Nervous System Metastases in Patients with HER2-Positive Breast Cancer
Giordano A, Kumthekar P, Jin Q, Kurt B, Ren S, Li T, Leone J, Mittendorf E, Pereslete A, Sharp L, Davis R, DiLullo M, Tayob N, Mayer E, Winer E, Tolaney S, Lin N. A Phase II Study of Atezolizumab, Pertuzumab, and High-Dose Trastuzumab for Central Nervous System Metastases in Patients with HER2-Positive Breast Cancer. Clinical Cancer Research 2024, 30: of1-of10. PMID: 39226397, PMCID: PMC11528201, DOI: 10.1158/1078-0432.ccr-24-1161.Peer-Reviewed Original ResearchConceptsHER2-positive breast cancer brain metastasesBreast cancer brain metastasesClinical benefit rateCancer brain metastasesCentral nervous systemCNS responseBrain metastasesOverall response rateOverall survivalAny-grade adverse eventsEffective systemic therapy optionsNeuro-Oncology Brain MetastasesHER2-positive breast cancerIntracranial partial responseSystemic therapy optionsPhase II studyPhase II trialCNS ORRRANO-BMDose delaysPartial responseII studyPrimary endpointHigh-doseBenefit rate1817MO Effect of a weight loss intervention (WLI) on exercise behaviors in women with breast cancer: Results from the breast cancer weight loss (BWEL) trial
Ligibel J, Ballman K, mccall L, Goodwin P, Weiss A, Crane T, Irwin M, Thomson C, Hahn O, Spears P, Hershman D, Paskett E, Hopkins J, Bernstein V, Stearns V, White J, Wadden T, Winer E, Carey L, Partridge A. 1817MO Effect of a weight loss intervention (WLI) on exercise behaviors in women with breast cancer: Results from the breast cancer weight loss (BWEL) trial. Annals Of Oncology 2024, 35: s1078. DOI: 10.1016/j.annonc.2024.08.1913.Peer-Reviewed Original ResearchAnalysis of HER2 expression changes from breast primary to brain metastases and the impact of HER2-low expression on overall survival
Pereslete A, Hughes M, Martin A, Files J, Nguyen K, Buckley L, Patel A, Moore A, Winer E, Dillon D, Li T, Tolaney S, Lin N, Sammons S. Analysis of HER2 expression changes from breast primary to brain metastases and the impact of HER2-low expression on overall survival. Neuro-Oncology 2024, noae163. PMID: 39211994, DOI: 10.1093/neuonc/noae163.Peer-Reviewed Original ResearchConceptsHER2-low expressionHER2-lowMetastatic breast cancerHER2-positiveHER2 expressionHER2-0Primary tumorBrain metastasesEstrogen receptorBreast cancerHER2-positive primary tumorsASCO-CAP guidelinesNCI-designated centersMultivariate survival analysisCox proportional hazards modelsAntibody-drug conjugatesProportional hazards modelActive antibody-drug conjugateASCO-CAPHER2 gainHER2 statusInferior survivalOverall survivalIntracranial activityRetrospective analysisBarriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study
Puklin L, Irwin M, Sanft T, Ferrucci L, Harrigan M, McGowan C, Cartmel B, Zupa M, Winer E, Deyling M, Ligibel J, Basen-Engquist K, Spiegelman D, Sharifi M. Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study. Supportive Care In Cancer 2024, 32: 590. PMID: 39141176, DOI: 10.1007/s00520-024-08789-5.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPhysical activityLifestyle interventionSelf-reported PA questionnaireSelf-reported diet qualityBreast cancerHealthy Eating Index-2015Stage I-III breast cancerBenefits of PASequential mixed methods studyI-III breast cancerChemotherapy-related symptomsMixed methods studyThematic content analysisBehavioral goalsSense of controlBody mass indexPA questionnaireSemi-structured interviewsMean body mass indexTranscribed verbatimIntervention armTailored educationDiet qualityNutritional behaviorMental benefitsNeratinib and ado-trastuzumab emtansine for pretreated and untreated human epidermal growth factor receptor 2 (HER2)-positive breast cancer brain metastases: Translational Breast Cancer Research Consortium trial 022 ☆
Freedman R, Heiling H, Li T, Trapani D, Tayob N, Smith K, Davis R, Pereslete A, DeMeo M, Cotter C, Chen W, Parsons H, Santa-Maria C, Van Poznak C, Moy B, Brufsky A, Melisko M, O’Sullivan C, Ashai N, Rauf Y, Nangia J, Burns R, Savoie J, Wolff A, Winer E, Rimawi M, Krop I, Lin N. Neratinib and ado-trastuzumab emtansine for pretreated and untreated human epidermal growth factor receptor 2 (HER2)-positive breast cancer brain metastases: Translational Breast Cancer Research Consortium trial 022 ☆. Annals Of Oncology 2024, 35: 993-1002. PMID: 38977064, DOI: 10.1016/j.annonc.2024.07.245.Peer-Reviewed Original ResearchConceptsHER2-positive breast cancer brain metastasesBreast cancer brain metastasesT-DM1Ado-trastuzumab emtansineCentral nervous systemOverall survivalCNS objective response rateEfficacy of neratinibT-DM1 exposureObjective response rateCancer brain metastasesPhase II studyMedian OSRANO-BMBrain MetastasesSlow accrualIntracranial activityII studyPrimary endpointPreclinical dataCohort 4Response assessmentTreatment optionsNeratinibPatients
Academic Achievements & Community Involvement
honor William Silen Lifetime Achievement in Mentoring Award
Hospital System AwardHarvard Medical SchoolDetails02/01/2022United Stateshonor Jill Rose Award for Scientific Excellence
Regional AwardBreast Cancer Research FoundationDetails01/01/2019United Stateshonor Susan G. Komen Brinker Award for Scientific Distinction in Clinical Research
Regional AwardSan Antonio Breast Cancer SymposiumDetails02/01/2018United States
Clinical Care
Overview
Eric Winer, MD, is the Director of Yale Cancer Center, as well as President and Physician-in-Chief of the Smilow Cancer Hospital Yale New Haven Health System. An internationally renowned medical oncologist and expert in breast cancer, his work has influenced almost all aspects of research and treatment of the disease.
Although he has always divided his time between patient care, research, and mentoring, Dr. Winer’s work as a clinician has driven him to ask research questions and strive to improve all aspects of care. In spite of many advances, there are still far too many individuals with breast cancer who either suffer from the cancer and treatment and sometimes lose their lives. In the United States alone, there are over 40,000 deaths each year, and there are 10 times as many worldwide.
Dr. Winer has long been an advocate of teams that include both scientists and clinicians as a means of accelerating research with the goal of advancing care. “Our mission at Yale is to deliver the best cancer care today and improve that care tomorrow and in the years ahead,” he says.
Dr. Winer is the Alfred Gilman Professor of Medicine and Pharmacology and Deputy Dean of Cancer Research at Yale School of Medicine. He is a past president of the American Society of Clinical Oncology (ASCO) and is a current member and past chair of its board of directors. For more than a decade, he served as chief scientific advisor and chair of the scientific advisory board for Susan G. Komen for the Cure and is now on the scientific advisory board of the Breast Cancer Research Foundation. He will be the board chair in 2025.
Dr. Winer has published over 600 articles, mentored, and has received numerous awards for his breast cancer research. He directed the breast cancer program at Dana-Farber Cancer Institute for over two decades, served as principal investigator of the Dana-Farber/Harvard Specialized Program of Research Excellence (SPORE), and won Harvard Medical School’s lifetime achievement award for mentoring. “I have seen the transformation of cancer care over the past three decades and look forward to even more remarkable advances over the next decade. Yale will continue to play an ever more prominent role in cancer care and research in the years ahead,” he says.
Board Certifications
Medical Oncology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1989
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 1987
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News
- January 13, 2025
Dr. Ian Krop and Alyssa Gateman on Yale Cancer Answers: Increasing Access to Clinical Trials
- January 04, 2025Source: Hartford Courant
CT cancer expert on U.S. surgeon general's warning about alcohol and cancer risk: ‘Cutting back makes sense’
- December 20, 2024Source: NBC Connecticut
Here's how inflammation can affect the body
- December 18, 2024Source: Newsweek
Cancer Dietitian Reveals Two Things She Tells People to Avoid Consuming
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