Sheila Nagamatsu, PhD
Postdoctoral AssociateDownloadHi-Res Photo
About
Titles
Postdoctoral Associate
Biography
As a postdoctoral associate at Yale University, I specialize in psychiatry genetics research. My primary focus is on epigenomic-wide association studies of various conditions, including smoking, opioid addiction, depression, and PTSD. I earned my Ph.D. in genetics and molecular biology from the University of Campinas in Brazil, where I focused on the bioinformatics of industrial yeasts and their application to bioethanol production.
Appointments
Departments & Organizations
Education & Training
- PhD
- University of Campinas, Genetics and Molecular Biology, Bioinformatics (2019)
- Internship
- Senai Institute of Innovation in Biomass (ISI BIOMASSA) (2015)
- BSc
- Federal University of São Carlos, Biotechnology (2013)
- Internship
- University of Campinas (2013)
- Internship
- University of the Basque Country (2013)
- President and Founder Member
- Federal University of São Carlos (UFSCar)/ CSB Júnior
- Non Degree Program
- Colégio Policursos, Technical School in Microcomputer Operator (2004)
Research
Overview
Medical Subject Headings (MeSH)
Biological Evolution; Genetic Background; Mutagenesis; Psychiatry and Psychology; Saccharomyces cerevisiae
ORCID
0000-0002-4986-5094- View Lab Website
Montalvo-ortiz Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Sheila Nagamatsu's published research.
Publications Timeline
A big-picture view of Sheila Nagamatsu's research output by year.
Research Interests
Research topics Sheila Nagamatsu is interested in exploring.
Janitza Montalvo-Ortiz, PhD
John Krystal, MD
Joel Gelernter, MD
Brenda Cabrera-Mendoza, MD/PhD
José Jaime Martínez-Magaña, BSc, MSc, PhD
Robert Pietrzak, PhD, MPH
31Publications
289Citations
Saccharomyces cerevisiae
Publications
2024
Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans
Fischer I, Na P, Nagamatsu S, Jeste D, Cabrera-Mendoza B, Montalvo-Ortiz J, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans. JAMA Psychiatry 2024, 81 PMID: 39476130, DOI: 10.1001/jamapsychiatry.2024.3403.Peer-Reviewed Original ResearchAltmetricT7. COVID-19 RELATED STRESSORS ARE ASSOCIATED WITH PSYCHIATRIC DISORDERS AND ACCELERATED EPIGENETIC AGING IN AN ISLAND-BASED PUERTO RICAN POPULATION
Garayua A, Nunez D, Nagamatsu S, Giusti-Rodriguez P, Martinez-Gonzalez K, Montalvo-Ortiz J. T7. COVID-19 RELATED STRESSORS ARE ASSOCIATED WITH PSYCHIATRIC DISORDERS AND ACCELERATED EPIGENETIC AGING IN AN ISLAND-BASED PUERTO RICAN POPULATION. European Neuropsychopharmacology 2024, 87: 159. DOI: 10.1016/j.euroneuro.2024.08.317.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderMajor depressive disorderCOVID-19 related stressorsCOVID-19 stressorsMajor depressive disorder symptomsPost-traumatic stress disorder symptomsAccelerated epigenetic agingRelated stressorsCombined sex analysesSymptoms of major depressive disorderPsychiatric disorder symptomsCOVID-19-related stressorsSex-stratified analysesSelf-report measuresCOVID-related stressorsAdverse mental health outcomesTargeted mental health interventionsSignificant stressorsAt-risk populationsMental health interventionsMental health outcomesConsequences of stressorsAccelerated biological agingEpigenetic ageAt-riskW69. ALTERNATIVE SPLICING DYNAMICS IN HUMAN PREFRONTAL CORTEX SUBREGIONS
Nunez D, Martinez-Magana J, Nagamatsu S, Andrade-Brito D, Hernandez-Amaya L, Montalvo-Ortiz J. W69. ALTERNATIVE SPLICING DYNAMICS IN HUMAN PREFRONTAL CORTEX SUBREGIONS. European Neuropsychopharmacology 2024, 87: 138-139. DOI: 10.1016/j.euroneuro.2024.08.278.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexPrefrontal cortex subregionsPrefrontal cortexOrbitofrontal cortexDifferential transcript usagePercent-spliced-inSubgenual prefrontal cortexPrefrontal cortex regionsAnterior cingulate cortexDorsolateral prefrontal cortexDSM-IV criteriaAS eventsTranscript usageSynaptic processesExon skippingDSM-IVSCID-1Cingulate cortexIntron retentionMood disordersPsychiatric disordersSplice siteAlternative splicingCognitive functionNon-psychiatric diagnosesONCOGENES AND TUMOR SUPPRESSOR GENES IN CARCINOMA EX PLEOMORPHIC ADENOMA DEVELOPMENT: OLD FACTS AND NEW HYPOTHESES.
SCARINI J, NAGAMATSU S, CARAZZOLLE M, Abu EGAL É, ALTEMANI A, CASTILHO R, MARIANO F. ONCOGENES AND TUMOR SUPPRESSOR GENES IN CARCINOMA EX PLEOMORPHIC ADENOMA DEVELOPMENT: OLD FACTS AND NEW HYPOTHESES. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 2024, 137: e303. DOI: 10.1016/j.oooo.2023.12.719.Peer-Reviewed Original ResearchConceptsTumor suppressor geneWhole-exome sequencingSingle nucleotide variantsGenetic alterationsAllele frequenciesSuppressor geneHg38 reference genomeDisease allele frequencyReference genomeSequence readsNucleotide variantsExome sequencingDNA samplesMYBOncogenic activityPublic databasesPleomorphic adenomaGenesOncogenePre-existing pleomorphic adenomaPotential involvementSequenceTP53Background CarcinomaRare tumorThe Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse
Martinez-Magaña J, Nagamatsu S, Nunez-Rios D, Krystal J, Girgenti M, Group T, Montalvo-Ortiz J. The Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse. Biological Psychiatry 2024, 95: s69. DOI: 10.1016/j.biopsych.2024.02.169.Peer-Reviewed Original ResearchMulti-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder
Nunez-Rios D, Hurd Y, Rompala G, Nagamatsu S, Martinez-Magaña J, Krystal J, Group T, Montalvo-Ortiz J. Multi-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder. Biological Psychiatry 2024, 95: s34. DOI: 10.1016/j.biopsych.2024.02.087.Peer-Reviewed Original ResearchNeuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder
Andrade-Brito D, Núñez-Ríos D, Martínez-Magaña J, Nagamatsu S, Rompala G, Zillich L, Witt S, Clark S, Lattig M, Montalvo-Ortiz J, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Keane T, Krystal J, Labadorf A, Logue M, Marx B, Mash D, McKee A, Miller M, Montalvo-Ortiz J, Noller C, Schnurr P, Scott W, Stein T, Ursano R, Williamson D, Wolf E, Young K. Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder. Frontiers In Genetics 2024, 15: 1345410. PMID: 38633406, PMCID: PMC11021708, DOI: 10.3389/fgene.2024.1345410.Peer-Reviewed Original ResearchCitationsConceptsAssociated with alcohol use disorderAlcohol use disorderOrbitofrontal cortexEpigenome-wide association studiesUse disorderStudy of alcohol use disorderHuman orbitofrontal cortexAlcohol-related traitsHuman brainPostmortem brain samplesHuman postmortem brain samplesEnrichment analysisDifferential CpG sitesPostmortem brain tissueGenome-wide levelOxidative bisulfite sequencingAssessed 5Functional enrichment analysisBrain tissueFalse discovery rateBisulfite sequencingAssociation studiesDifferential methylationIdentified genesDNA methylationCorrection: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2024, 49: 764-764. PMID: 38182778, PMCID: PMC10876612, DOI: 10.1038/s41386-023-01786-y.Peer-Reviewed Original Research
2023
Know-how of holding a Bioinformatics competition: Structure, model, overview, and perspectives
Horácio E, de Carvalho L, Pereira G, Abrahim M, Coelho M, De Jesus D, García G, de Melo-Minardi R, Nagamatsu S. Know-how of holding a Bioinformatics competition: Structure, model, overview, and perspectives. PLOS Computational Biology 2023, 19: e1011679. PMID: 38127831, PMCID: PMC10735175, DOI: 10.1371/journal.pcbi.1011679.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsPsychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2023, 49: 699-708. PMID: 37848731, PMCID: PMC10876568, DOI: 10.1038/s41386-023-01747-5.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPolygenic risk scoresRisk scoreGenetic predispositionModifiable psychosocial variablesAge-related morbidityGamma-glutamyl transferaseInflammatory biomarkersSystemic inflammationNational HealthApolipoprotein BMale veteransPsychosocial factorsVeterans StudySaliva samplesPsychosocial moderatorsPsychosocial variablesAntihistamine drugsMilitary veteransGrimAgeGrimAge accelerationInflammationUK BiobankDrugsRepresentative samplePredisposition
Academic Achievements & Community Involvement
activity Frontiers in Psychiatry
Journal ServiceReviewerDetails2023 - Presentactivity Frontiers in Genetics
Journal ServiceReviewerDetails02/02/2023 - Presenthonor Best Poster at 4th Annual Postdoc Symposium
Yale University AwardYale Postdoc SymposiumDetails06/17/2021United Stateshonor SHARP Training Scholarship Awards for Trainees and Career Development
National AwardThe SHARP Scholarship CommitteeDetails03/31/2021United Stateshonor Oral Finalist at the World Congress of Psychiatric Genetics
Other AwardWCPGDetails10/16/2020United States
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Mailing Address
Montalvo-Ortiz Lab
Errera Community Care Center-Orange Annex, 200 Edison Road, room 1342-22.
Orange, CT 06477
United States