Zyad James Carr, MD
Associate Professor of AnesthesiologyCards
About
Research
Overview
My current research interest is identification, quantification, and mitigation of perioperative complications. Shifting the paradigm of preoperative risk assessment to a precise, individualized and patient centered approach is one of my areas of research interest. In addition, I am interested in estimation and characterization of perioperative pulmonary complications, particularly in the care of previously neglected medical populations.
Medical Research Interests
Critical Care; Diseases; Lung Diseases, Interstitial; Perioperative Care; Perioperative Medicine; Postoperative Care
Public Health Interests
Pharmaceuticals and Medical Devices; Cardiovascular Diseases; Antimicrobial Resistance; Bioinformatics; Emerging Infectious Diseases; Infectious Diseases
Publications
Featured Publications
Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study
Carr Z, Agarkov D, Li J, Charchaflieh J, Brenes-Bastos A, Freund J, Zafar J, Schonberger R, Heerdt P. Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Presurgical Evaluation Clinic: Feasibility Cohort Study. JMIR Perioperative Medicine 2025, 8: e65805. PMID: 39773953, PMCID: PMC11888076, DOI: 10.2196/65805.Peer-Reviewed Original ResearchConceptsDuke Activity Status IndexPeak oxygen uptakePeak METsEvaluation clinicParticipant satisfactionOxygen uptakeSubmaximal cardiopulmonary exercise testingFunctional capacity assessmentLow functional capacityCardiopulmonary exercise testingPerceived exertionMET assessmentStructured surveyCapacity surveyMedian patient satisfactionProvider-drivenExercise testMean session timePearson correlation coefficientSurvey scoresCardiopulmonary testFunctional capacityPatient satisfactionCohort studyInclusion criteria
2025
Thirty-day postoperative cardiopulmonary complications in sarcoidosis: Insights from a retrospective matched cohort analysis
Freund J, Gosalvez C, Rady A, Notarianni A, Carr Z. Thirty-day postoperative cardiopulmonary complications in sarcoidosis: Insights from a retrospective matched cohort analysis. Anesthesiology And Perioperative Science 2025, 3: 9. DOI: 10.1007/s44254-025-00087-5.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsPostoperative cardiopulmonary complicationsLength of staySarcoidosis patientsSarcoidosis diagnosisCardiopulmonary complicationsCohort analysisAssociated with 30-day MACEIndependent of disease stageSystemic granulomatous disorderRetrospective matched cohort analysisMethodsThis retrospective studyAssociated with higher riskCongestive heart failure eventsComparative cohort analysisHeart failure eventsPreoperative chest radiographyAdverse cardiovascular eventsMatched cohort analysisCompared to controlsPulmonary complicationsSarcoidosis cohortGranulomatous disorderLung involvementThirty-dayThe role of right ventricular systolic pressure and ARISCAT score in perioperative pulmonary risk assessment
Tatsuoka Y, He Z, Lin H, Notarianni A, Carr Z. The role of right ventricular systolic pressure and ARISCAT score in perioperative pulmonary risk assessment. Brazilian Journal Of Anesthesiology 2025, 75: 844597. PMID: 39971234, PMCID: PMC11914786, DOI: 10.1016/j.bjane.2025.844597.Peer-Reviewed Original ResearchConceptsRight ventricular systolic pressurePostoperative pulmonary complicationsArea under the curveARISCAT scoreVentricular systolic pressureReceiver operating characteristic curvePulmonary hypertensionRespiratory failureHigh-risk populationPrimary endpointRisk stratificationSurgical proceduresSystolic pressurePostoperative pulmonary complications incidenceSource of increased morbidityAssess Respiratory RiskDiagnosis of PHPreoperative risk assessmentAdjusted multivariable logistic regression modelsMultivariate logistic regression modelComposite of pneumoniaPulmonary complicationsPreoperative investigationsSecondary endpointsPulmonary aspirationPerioperative Pulmonary Complications in the Older Adults The Forgotten System
Carr Z, Siller S, McDowell B. Perioperative Pulmonary Complications in the Older Adults The Forgotten System. Clinics In Geriatric Medicine 2025, 41: 1-18. PMID: 39551535, DOI: 10.1016/j.cger.2024.03.003.Peer-Reviewed Original ResearchPheochromocytoma and MEN Syndromes
Carr Z, Farela A, Oprea A. Pheochromocytoma and MEN Syndromes. 2025, 333-342. DOI: 10.1093/med/9780190902001.003.0030.Peer-Reviewed Original ResearchMultiple endocrine neoplasiaInadequate surgical resectionManagement of PPGLsRare neuroendocrine tumorsDefinitive surgical managementResection of pheochromocytomaPreoperative medical managementDiligent postoperative careHigh-risk procedurePersistent vasoplegiaResected patientsSurgical resectionNeuroendocrine tumorsPostoperative bleedingRefractory hypertensionVasopressor supportHypertensive crisisPreoperative optimizationEndocrine neoplasiaABSTRACT PheochromocytomaPostoperative periodPerioperative considerationsVentricular dysrhythmiasAnesthesia techniquesPotential complications
2024
The Impact of Cannabis Use Disorder on Critical Illness
Carr Z, Strand E. The Impact of Cannabis Use Disorder on Critical Illness. 2024, 95-105. DOI: 10.1007/978-3-031-67069-5_7.Peer-Reviewed Original ResearchIntensive care unitImpacts of cannabis use disordersCannabis use disorderManagement of patientsIntensive care managementIntensive care management of patientsChronic adverse effectsCannabis useClinical evidenceCare management of patientsBotanical cannabisCannabis usageCare unitUse disorderCannabisOrgan systemsAdverse effectsPatientsDownstream effectsIntensive care unit providersMedical careCare managementDoes a single oral administration of amiloride affect spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults?
Fernandes I, Stavres J, Hamaoka T, Ojikutu Q, Sabino-Carvalho J, Vianna L, Luck J, Blaha C, Cauffman A, Dalton P, Herr M, Ruiz-Velasco V, Carr Z, Janicki P, Cui J. Does a single oral administration of amiloride affect spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults? Journal Of Neurophysiology 2024, 132: 922-928. PMID: 39110514, DOI: 10.1152/jn.00264.2024.Peer-Reviewed Original ResearchAdministration of amilorideArterial baroreflex sensitivityCardiac autonomic modulationBaroreflex sensitivityOral administrationBP variabilityBlood pressureOral administration of placeboAutonomic modulationSpontaneous cardiac baroreflexSympathetic arterial baroreflexAdministration of placeboIndices of BP variabilityMuscle sympathetic activitySympathetic baroreflex sensitivityHealthy young adultsPre-clinical modelsSingle oral administrationBlood pressure variabilityBeat-to-beat BPYoung adultsWeighted linear regression analysisHealthy young humansSympathetic baroreflexAmilorideIdentifying, Understanding, and Minimizing Unconscious Cognitive Biases in Perioperative Crisis Management: A Narrative Review
Yan L, Karamchandani K, Gaiser R, Carr Z. Identifying, Understanding, and Minimizing Unconscious Cognitive Biases in Perioperative Crisis Management: A Narrative Review. Anesthesia & Analgesia 2024, 139: 68-77. PMID: 37874227, DOI: 10.1213/ane.0000000000006666.Peer-Reviewed Original ResearchPulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis
Tatsuoka Y, Carr Z, Jayakumar S, Lin H, He Z, Farroukh A, Heerdt P. Pulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis. Journal Of Clinical Medicine 2024, 13: 1996. PMID: 38610760, PMCID: PMC11012853, DOI: 10.3390/jcm13071996.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsLength of stayPulmonary hypertensionPulmonary complicationsPulmonary embolismRespiratory failureEndoscopic proceduresRisk of postoperative complicationsPulmonary artery pressurePreoperative risk assessmentProlonged length of stayRetrospective cohort studySub-cohort analysisIncreased LOSPropensity score overlap weightingOverlap weightingAssociation of PHPH cohortPH patientsPostoperative complicationsAbdominal surgeryRate of RFCohort studyControl cohortArterial pressureFurther innovation is required to enhance risk prediction of postoperative pulmonary complications
Carr, Z.J. Further innovation is required to enhance risk prediction of postoperative pulmonary complications—comment on Anesthesiol Perioper Sci. 2023;1(4):34. APS 2, 14 (2024). https://doi.org/10.1007/s44254-024-00053-7Commentaries, Editorials and Letters
Academic Achievements & Community Involvement
Clinical Care
Overview
Zyad James Carr, MD, is an anesthesiologist who specializes in critical care, helping patients navigate the challenges of surgery and recovery. He uses advanced methods to monitor vital functions, including breathing and circulation, for individuals who require high levels of support during and after procedures.
As an associate professor of anesthesiology at Yale School of Medicine, Dr. Carr focuses his research on identifying, measuring, and reducing complications that can arise in the time around surgery. He seeks to customize risk assessment to the needs of each patient, especially those at greater risk for lung issues and other serious conditions.
Dr. Carr completed his medical training at University College Cork, National University of Ireland. He pursued residency training in anesthesiology at the University of Medicine and Dentistry of New Jersey, Cooper University Hospital, followed by a fellowship in critical care medicine at Dartmouth Hitchcock Medical Center.
Clinical Specialties
Anesthesiology; Critical Care Anesthesiology
Board Certifications
Advanced Perioperative Transesophageal Echocardiography
- Certification Organization
- National Board of Echocardiography
- Original Certification Date
- 2015
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 2011
Links
Media
- Rapid determination of the cause of postoperative hypoxia in ILD patients is critical to successful rescue.
Get In Touch
Contacts
Email
Mailing Address
Anesthesiology
333 Cedar Street, TMP-3
New Haven, Connecticut 05610
United States