Zyad James Carr, MD
Associate Professor of AnesthesiologyCards
About
Research
Overview
My current research interest is identification, quantification, and mitigation of perioperative complications. Shifting the paradigm of preoperative risk assessment to a precise, individualized and patient centered approach is one of my areas of research interest. In addition, I am interested in estimation and characterization of perioperative pulmonary complications, particularly in the care of previously neglected medical populations.
Medical Research Interests
Critical Care; Diseases; Lung Diseases, Interstitial; Perioperative Care; Perioperative Medicine; Postoperative Care
Public Health Interests
Emerging Infectious Diseases; Cardiovascular Diseases; Bioinformatics; Antimicrobial Resistance; Pharmaceuticals and Medical Devices; Infectious Diseases
Publications
Featured Publications
Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Pre-surgical Evaluation Clinic: A feasibility study.
Carr Z, Agarkov D, Li J, Charchaflieh J, Brenes-Bastos A, Freund J, Zafar J, Schonberger RB, Heerdt P. Implementation of Brief Submaximal Cardiopulmonary Testing in a High-Volume Pre-surgical Evaluation Clinic: A feasibility study. JMIR Perioper Med 2025 PMID: 39773953, DOI: 10.2196/65805.Peer-Reviewed Original Research
2025
Perioperative Pulmonary Complications in the Older Adults The Forgotten System
Carr Z, Siller S, McDowell B. Perioperative Pulmonary Complications in the Older Adults The Forgotten System. Clinics In Geriatric Medicine 2025, 41: 1-18. PMID: 39551535, DOI: 10.1016/j.cger.2024.03.003.Peer-Reviewed Original Research
2024
The Impact of Cannabis Use Disorder on Critical Illness
Carr Z, Strand E. The Impact of Cannabis Use Disorder on Critical Illness. 2024, 95-105. DOI: 10.1007/978-3-031-67069-5_7.Peer-Reviewed Original ResearchIntensive care unitImpacts of cannabis use disordersCannabis use disorderManagement of patientsIntensive care managementIntensive care management of patientsChronic adverse effectsCannabis useClinical evidenceCare management of patientsBotanical cannabisCannabis usageCare unitUse disorderCannabisOrgan systemsAdverse effectsPatientsDownstream effectsIntensive care unit providersMedical careCare managementDoes a single oral administration of amiloride affect spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults?
Fernandes I, Stavres J, Hamaoka T, Ojikutu Q, Sabino-Carvalho J, Vianna L, Luck J, Blaha C, Cauffman A, Dalton P, Herr M, Ruiz-Velasco V, Carr Z, Janicki P, Cui J. Does a single oral administration of amiloride affect spontaneous arterial baroreflex sensitivity and blood pressure variability in healthy young adults? Journal Of Neurophysiology 2024, 132: 922-928. PMID: 39110514, DOI: 10.1152/jn.00264.2024.Peer-Reviewed Original ResearchAdministration of amilorideArterial baroreflex sensitivityCardiac autonomic modulationBaroreflex sensitivityOral administrationBP variabilityBlood pressureOral administration of placeboAutonomic modulationSpontaneous cardiac baroreflexSympathetic arterial baroreflexAdministration of placeboIndices of BP variabilityMuscle sympathetic activitySympathetic baroreflex sensitivityHealthy young adultsPre-clinical modelsSingle oral administrationBlood pressure variabilityBeat-to-beat BPYoung adultsWeighted linear regression analysisHealthy young humansSympathetic baroreflexAmiloridePulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis
Tatsuoka Y, Carr Z, Jayakumar S, Lin H, He Z, Farroukh A, Heerdt P. Pulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis. Journal Of Clinical Medicine 2024, 13: 1996. PMID: 38610760, PMCID: PMC11012853, DOI: 10.3390/jcm13071996.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsLength of stayPulmonary hypertensionPulmonary complicationsPulmonary embolismRespiratory failureEndoscopic proceduresRisk of postoperative complicationsPulmonary artery pressurePreoperative risk assessmentProlonged length of stayRetrospective cohort studySub-cohort analysisIncreased LOSPropensity score overlap weightingOverlap weightingAssociation of PHPH cohortPH patientsPostoperative complicationsAbdominal surgeryRate of RFCohort studyControl cohortArterial pressureFurther innovation is required to enhance risk prediction of postoperative pulmonary complications
Carr, Z.J. Further innovation is required to enhance risk prediction of postoperative pulmonary complications—comment on Anesthesiol Perioper Sci. 2023;1(4):34. APS 2, 14 (2024). https://doi.org/10.1007/s44254-024-00053-7Commentaries, Editorials and LettersFurther innovation is required to enhance risk prediction of postoperative pulmonary complications—comment on Anesthesiol Perioper Sci. 2023;1(4):34
Carr Z. Further innovation is required to enhance risk prediction of postoperative pulmonary complications—comment on Anesthesiol Perioper Sci. 2023;1(4):34. Anesthesiology And Perioperative Science 2024, 2: 14. DOI: 10.1007/s44254-024-00053-7.Peer-Reviewed Original ResearchEstimates of 30-day postoperative pulmonary complications after gastrointestinal endoscopic procedures: A retrospective cohort analysis of a health system population
Carr Z, Li J, Agarkov D, Gazura M, Karamchandani K. Estimates of 30-day postoperative pulmonary complications after gastrointestinal endoscopic procedures: A retrospective cohort analysis of a health system population. PLOS ONE 2024, 19: e0299137. PMID: 38394250, PMCID: PMC10889900, DOI: 10.1371/journal.pone.0299137.Peer-Reviewed Original ResearchConceptsPostoperative pulmonary complicationsGastrointestinal endoscopic proceduresCongestive heart failurePropensity score matchingEndoscopic proceduresPulmonary complicationsSecondary outcomesPropensity score matching adjustmentRetrospective cohort studyRetrospective cohort analysisPulmonary circulatory disordersMultivariate logistic regressionAlcohol abuse disordersUpper endoscopic proceduresHealth system populationPulmonary emboliUpper endoscopyRespiratory failureLower endoscopyElectrolyte disordersHeart failureCohort studyConscious sedationPrimary outcomeCohort analysis
2023
Identifying, Understanding, and Minimizing Unconscious Cognitive Biases in Perioperative Crisis Management: A Narrative Review
Yan L, Karamchandani K, Gaiser R, Carr Z. Identifying, Understanding, and Minimizing Unconscious Cognitive Biases in Perioperative Crisis Management: A Narrative Review. Anesthesia & Analgesia 2023, 139: 68-77. PMID: 37874227, DOI: 10.1213/ane.0000000000006666.Peer-Reviewed Original ResearchPredictors of Failure to Rescue After Postoperative Respiratory Failure: A Retrospective Cohort Analysis of 13,047 Patients Using the ACS-NSQIP Dataset
Karamchandani K, Khorsand S, Ebeling C, Yan L, Nakonezny P, Carr Z. Predictors of Failure to Rescue After Postoperative Respiratory Failure: A Retrospective Cohort Analysis of 13,047 Patients Using the ACS-NSQIP Dataset. Journal Of Surgical Research 2023, 293: 482-489. PMID: 37827025, DOI: 10.1016/j.jss.2023.09.030.Peer-Reviewed Original ResearchConceptsPostoperative respiratory failurePredictors of failureDay of surgeryRespiratory failureNoncardiac surgeryNational Surgical Quality Improvement Project databaseSurgeons National Surgical Quality Improvement Project databaseMultiple logistic regression modelACS-NSQIP datasetsPreoperative prealbumin levelRetrospective cohort studyAnesthesiologists physical statusRetrospective cohort analysisLogistic regression modelsPreoperative ascitesPreoperative creatininePostoperative complicationsPrealbumin levelsCohort studyStudy cohortDisseminated cancerCohort analysisAmerican CollegePatientsPhysical status
Academic Achievements & Community Involvement
Clinical Care
Overview
Clinical Specialties
Anesthesiology; Critical Care Anesthesiology
Board Certifications
Advanced Perioperative Transesophageal Echocardiography
- Certification Organization
- National Board of Echocardiography
- Original Certification Date
- 2015
Anesthesiology
- Certification Organization
- AB of Anesthesiology
- Original Certification Date
- 2011
Links
Media
- Rapid determination of the cause of postoperative hypoxia in ILD patients is critical to successful rescue.
Get In Touch
Contacts
Email
Mailing Address
Anesthesiology
333 Cedar Street, TMP-3
New Haven, Connecticut 05610
United States