2022
Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration
Suzuki A, Tillmann H, Williams J, Hauser R, Frund J, Suzuki M, Prior F, Aithal G, Lucena M, Andrade R, Tong W, Hunt C. Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration. Drug Safety 2022, 46: 129-143. PMID: 36547811, DOI: 10.1007/s40264-022-01255-3.Peer-Reviewed Original ResearchConceptsPre-existing liver conditionsAcute liver injuryAmoxicillin/clavulanateDrug-induced liver injuryLiver injuryLiver conditionsElectronic health record systemsHealth record systemsSignificant drug-induced liver injuryAcute Liver Injury AssociatedLiver Injury AssociatedOverall mortality riskGeneral patient populationVeterans Health AdministrationAlkaline phosphatase elevationSignificant health issueRecord systemLarge electronic health record datasetsElectronic health record datasetBilirubin elevationCholestatic injuryInpatient exposureInjury AssociatedLarge electronic health record systemHepatocellular injury
2021
Clinical knowledge extraction via sparse embedding regression (KESER) with multi-center large scale electronic health record data
Hong C, Rush E, Liu M, Zhou D, Sun J, Sonabend A, Castro VM, Schubert P, Panickan VA, Cai T, Costa L, He Z, Link N, Hauser R, Gaziano JM, Murphy SN, Ostrouchov G, Ho YL, Begoli E, Lu J, Cho K, Liao KP, Cai T. Clinical knowledge extraction via sparse embedding regression (KESER) with multi-center large scale electronic health record data. Npj Digital Medicine 2021, 4: 151. PMID: 34707226, PMCID: PMC8551205, DOI: 10.1038/s41746-021-00519-z.Peer-Reviewed Original ResearchCode embeddingsKnowledge extractionFeature selectionTraditional data mining approachesClinical knowledge extractionKnowledge mapData mining approachElectronic health record systemsPatient-level dataHealth record systemsDomain expertsMining approachDisease-drug pairsLarge-scale electronic health record dataEHR dataElectronic health record dataRelevant featuresRecord systemComparable performanceEmbeddingHealth record dataRelevant codesMulti-center studySingle-institution dataKESER