James Macy Jr, DVM
Professor of Comparative MedicineCards
About
Research
Publications
2024
The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity
Laughlin M, McIndoe R, Adams S, Araiza R, Ayala J, Kennedy L, Lanoue L, Lantier L, Macy J, Malabanan E, McGuinness O, Perry R, Port D, Qi N, Elias C, Shulman G, Wasserman D, Lloyd K. The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity. Mammalian Genome 2024, 35: 485-496. PMID: 39191872, PMCID: PMC11522164, DOI: 10.1007/s00335-024-10067-y.Peer-Reviewed Original ResearchMouse Metabolic Phenotyping CentersMouse model of diabetesModels of diabetesNational Institutes of HealthNational Institute for DiabetesDigestive and Kidney DiseasesBehavioral phenotyping testsRenal functionProcedure in vivoFood intakeIn vivo characterizationMouse modelHeterogeneity of diabetesKidney diseaseBody compositionPhenotyping CentersInstitutes of HealthMiceObesityDiabetesPhenotypic testsWhole-body carbohydrateInsulin actionLipid metabolismLiving mice
2019
Chapter 13 Viral Disease
Macy J, Compton S. Chapter 13 Viral Disease. 2019, 541-568. PMCID: PMC7153344, DOI: 10.1016/b978-0-12-814338-4.00013-1.Peer-Reviewed Original Research
2004
Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice.
Compton SR, Ball-Goodrich LJ, Johnson LK, Johnson EA, Paturzo FX, Macy JD. Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice. Comparative Medicine 2004, 54: 681-9. PMID: 15679267.Peer-Reviewed Original ResearchConceptsT cell-deficient miceCell-deficient miceMouse hepatitis virusBALB/cGastrointestinal tractC57BL/6 miceLymphoid tissueViral RNASubclinical infectionHepatitis virusInfected B-cell-deficient miceSmall intestineEnterotropic mouse hepatitis virusB cell-deficient miceImmunocompetent BALB/cMost natural infectionsChronic subclinical infectionMultiple organ systemsTranscriptase-polymerase chain reaction analysisImmunocompetent miceLethal infectionEnterotropic strainsT cellsImmunodeficient miceIntestinal mucosaPromises to keep (Part 2).
Jacoby RO, Macy JD. Promises to keep (Part 2). Comparative Medicine 2004, 54: 11-2. PMID: 15027613.Peer-Reviewed Original ResearchTransmission of enterotropic mouse hepatitis virus from immunocompetent and immunodeficient mice.
Compton SR, Ball-Goodrich LJ, Paturzo FX, Macy JD. Transmission of enterotropic mouse hepatitis virus from immunocompetent and immunodeficient mice. Comparative Medicine 2004, 54: 29-35. PMID: 15027615.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Outbred StrainsFecesFemaleHepatitis, Viral, AnimalImmunocompetenceImmunocompromised HostInfectious Disease Transmission, VerticalMiceMice, Inbred StrainsMurine hepatitis virusReverse Transcriptase Polymerase Chain ReactionRNA, ViralRodent DiseasesSentinel SurveillanceSpecies SpecificityVirus SheddingConceptsCell-deficient miceEnterotropic mouse hepatitis virusT cell-deficient miceMouse hepatitis virusInfected miceIntestinal infectionsC57BL/6 miceHepatitis virusB cell-deficient miceViral RNABALB/c miceSevere disseminated diseaseNon-infectious RNADisseminated diseaseNaive miceC miceMHV infectionImmunodeficient miceSentinel miceBALB/ cViral transmissionInfectionMiceVirus RNAWeeks
2003
Pathogenesis of mouse hepatitis virus infection in gamma interferon-deficient mice is modulated by co-infection with Helicobacter hepaticus.
Compton SR, Ball-Goodrich LJ, Zeiss CJ, Johnson LK, Johnson EA, Macy JD. Pathogenesis of mouse hepatitis virus infection in gamma interferon-deficient mice is modulated by co-infection with Helicobacter hepaticus. Comparative Medicine 2003, 53: 197-206. PMID: 12784855.Peer-Reviewed Original ResearchConceptsIFN-gamma KO miceGamma interferon-deficient miceMouse hepatitis virusInterferon-deficient miceDevelopment of peritonitisKO miceH. hepaticusMultisystemic infectionHelicobacter hepaticusMouse hepatitis virus infectionHepatitis virus infectionAberrant immune responseSelf-limiting infectionMinimal pathologic changesMultifocal hepatic necrosisLater time pointsAcute necrotizingAcute peritonitisAcute phaseInflammatory lesionsImmunocompetent miceChronic infectionHepatic necrosisMHV infectionPathologic changes
2002
Assessment of static isolator cages with automatic watering when used with conventional husbandry techniques as a factor in the transmission of mouse hepatitis virus.
Macy JD, Cameron GA, Ellis SL, Hill EA, Compton SR. Assessment of static isolator cages with automatic watering when used with conventional husbandry techniques as a factor in the transmission of mouse hepatitis virus. Journal Of The American Association For Laboratory Animal Science 2002, 41: 30-5. PMID: 12109894.Peer-Reviewed Original ResearchConceptsFilter-top cagesMouse hepatitis virusUninoculated miceHepatitis virusCages of miceTransmission of infectionExamination of fecesLong-term useImmunocompetent miceHigh virus concentrationsPolymerase chain reaction amplificationMiceChain reaction amplificationWeeksStandard cagesMHV-A59Fecal samplesRoutine husbandrySerologyTest cageVirusInfected cagesInfectionReaction amplificationRows of cages
2001
Anisocoria and middle cerebral artery saccular (berry) aneurysm in a rhesus macaque (Macaca mulatta).
Ovadia S, Zeiss C, Reuter J, Macy J. Anisocoria and middle cerebral artery saccular (berry) aneurysm in a rhesus macaque (Macaca mulatta). Comparative Medicine 2001, 51: 562-6. PMID: 11924821.Peer-Reviewed Original ResearchConceptsRight optic tractLeft pupilOptic tractRight middle cerebral arteryIntracranial aneurysmsRhesus macaquesParasympathetic efferent pathwaysRight middle cerebralLeft oculomotor nerveMiddle cerebral arteryInternal carotid arteryFemale rhesus macaquesMiddle cerebralNeurologic deficitsArteriosclerotic changesCerebral arteryEfferent pathwaysOculomotor nerveUnrelated reasonsVisual deficitsBerry aneurysmsCarotid arteryUnruptured aneurysmsConstrictor muscleAnisocoriaLatex sensitivity in a macaque (Macaca mulatta).
Macy J, Huether M, Beattie T, Findlay H, Zeiss C. Latex sensitivity in a macaque (Macaca mulatta). Comparative Medicine 2001, 51: 467-72. PMID: 11924808.Peer-Reviewed Original ResearchConceptsDelayed-type hypersensitivity reactionFlares of dermatitisAllergen-specific IgE testingSkin prick testPunch biopsy specimenAdult Macaca mulattaDifferen-tial diagnosisLatex sensitivityCorneal stainingThyroid profilePrick testAtopic dermatitisIgE testingLatex allergyHypersensitivity reactionsBiopsy specimenContact allergensSignificant inflammationEosinophilic dermatitisOriginal biopsyInguinal regionAllergic dermatitisSkin scrapingsVinyl glovesFourteen weeks
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