2024
APOE ε4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation
Renedo D, Rivier C, Koo A, Sujijantarat N, Clocchiatti-Tuozzo S, Wu K, Torres-Lopez V, Huo S, Gunel M, de Havenon A, Sheth K, Matouk C, Falcone G. APOE ε4 and Intracerebral Hemorrhage in Patients With Brain Arteriovenous Malformation. JAMA Network Open 2024, 7: e2355368. PMID: 38363572, PMCID: PMC10873768, DOI: 10.1001/jamanetworkopen.2023.55368.Peer-Reviewed Original ResearchConceptsApolipoprotein E e4Participants of European ancestryRisk of intracerebral hemorrhageHigh risk of intracerebral hemorrhageCross-sectional studyUK BiobankEuropean ancestryHigh riskUs Research ProgramUK Biobank participantsInternational Classification of DiseasesAssociated with higher risk of ICHCross-sectional study of patientsAPOE e4 statusClassification of DiseasesApolipoprotein ENinth Revision and Tenth RevisionAssociated with higher riskIndividual-level dataMultivariate logistic regressionIntracerebral hemorrhage riskBrain arteriovenous malformationsIntracerebral hemorrhageBiobank participantsTenth Revision
2020
Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage
Biffi A, Urday S, Kubiszewski P, Gilkerson L, Sekar P, Rodriguez-Torres A, Bettin M, Charidimou A, Pasi M, Kourkoulis C, Schwab K, DiPucchio Z, Behymer T, Osborne J, Morgan M, Moomaw CJ, James ML, Greenberg SM, Viswanathan A, Gurol ME, Worrall BB, Testai FD, McCauley JL, Falcone GJ, Langefeld CD, Anderson CD, Kamel H, Woo D, Sheth KN, Rosand J. Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage. Stroke 2020, 51: 2153-2160. PMID: 32517581, PMCID: PMC7311289, DOI: 10.1161/strokeaha.120.028310.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsApolipoprotein E4Cerebral HemorrhageFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingRecurrenceConceptsCortical superficial siderosisICH recurrenceCerebral microbleedsSuperficial siderosisIntracerebral hemorrhageRecurrent ICHMRI markersOral anticoagulation therapyPotent risk factorRecurrent hemorrhagic strokeLongitudinal cohort studyLow-risk categoryLow-risk individualsΕ2/ε4ICH survivorsAnticoagulation therapyCohort studyHemorrhagic strokeProspective studyRecurrence rateΕ4 variantRisk factorsClinical impactERICH studyΕ4 allele