2024
White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults
de Havenon A, Gottesman R, Willamson J, Rost N, Sharma R, Li V, Littig L, Stulberg E, Falcone G, Prabhakaran S, Schneider A, Sheth K, Pajewski N, Brickman A. White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults. Alzheimer's & Dementia 2024, 20: 6810-6819. PMID: 39229896, PMCID: PMC11485393, DOI: 10.1002/alz.14126.Peer-Reviewed Original ResearchRisk of cognitive impairmentYears of follow-upCognitive impairmentExposure categoriesHigh-risk categoryWhite matter hyperintensitySystolic Blood Pressure Intervention TrialRates of cognitive impairmentSPRINT-MIND trialDementia preventionFollow-upLow-risk categoryMIND trialAdditional risk factorsDevelopment of cognitive impairmentIntervention trialsHypertensive adultsHazard ratioRisk factorsHigh riskLow riskVascular healthTertileRiskImpairment
2014
Interrelationship of superficial siderosis and microbleeds in cerebral amyloid angiopathy
Shoamanesh A, Martinez-Ramirez S, Oliveira-Filho J, Reijmer Y, Falcone GJ, Ayres A, Schwab K, Goldstein JN, Rosand J, Gurol ME, Viswanathan A, Greenberg SM. Interrelationship of superficial siderosis and microbleeds in cerebral amyloid angiopathy. Neurology 2014, 83: 1838-1843. PMID: 25320098, PMCID: PMC4240429, DOI: 10.1212/wnl.0000000000000984.Peer-Reviewed Original ResearchConceptsCortical superficial siderosisCerebral amyloid angiopathyCMB countCerebral microbleedsSuperficial siderosisAmyloid angiopathyΕ4 allele frequencyCross-sectional analysisCSS presenceAPOE genotypeAPOE ε4MRI scansAngiopathyMicrobleedsSiderosisCountSeverityGenetic associationLongitudinal research studyCS relativeDistinct patternsAllele frequenciesSubjectsIndividualsTertile