2022
Association of Soluble ST2 With Functional Outcome, Perihematomal Edema, and Immune Response After Intraparenchymal Hemorrhage
Bevers M, Booraem C, Li K, Sreekrishnan A, Sastre C, Falcone G, Sheth K, Sansing L, Kimberly W. Association of Soluble ST2 With Functional Outcome, Perihematomal Edema, and Immune Response After Intraparenchymal Hemorrhage. Neurology 2022, 100: e1329-e1338. PMID: 36549913, PMCID: PMC10065211, DOI: 10.1212/wnl.0000000000206764.Peer-Reviewed Original ResearchConceptsSoluble ST2Deep intraparenchymal hemorrhageIntraparenchymal hemorrhagePerihematomal edemaImmune responseHematoma volumePoor outcomeFunctional outcomeMedian admission Glasgow Coma Scale scoreScale scoreAdmission Glasgow Coma Scale scorePeripheral innate immune responseModified Rankin Scale scoreGlasgow Coma Scale scoreHours of ictusPeripheral immune responseSecondary brain injuryRankin Scale scoreInnate immune cellsImmune cell populationsIntracerebral Hemorrhage ScoreSerial CT scansInnate immune responseHuman brain tissueSST2 levels
2021
Similar admission NIHSS may represent larger tissue-at-risk in patients with right-sided versus left-sided large vessel occlusion
Mak A, Matouk C, Avery EW, Behland J, Frey D, Madai VI, Vajkoczy P, Malhotra A, Karam A, Sanelli P, Falcone GJ, Petersen NH, Sansing L, Sheth KN, Payabvash S. Similar admission NIHSS may represent larger tissue-at-risk in patients with right-sided versus left-sided large vessel occlusion. Journal Of NeuroInterventional Surgery 2021, 14: 985-991. PMID: 34645705, DOI: 10.1136/neurintsurg-2021-017785.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionFinal infarct volumeLarger final infarct volumeWorse discharge outcomesInfarct volumeAdmission NIHSSDischarge outcomesVessel occlusionScale scoreMultivariate analysisAnterior large vessel occlusionLower admission NIHSS scoreHealth Stroke Scale scoreAdmission National InstitutesAdmission stroke severityPoor discharge outcomeStroke Scale scoreLarger infarct volumesAdmission NIHSS scoreRankin Scale scoreVoxel-wise analysisIncomplete reperfusionInfarct distributionOcclusion sideNIHSS score
2019
Differences in Admission Blood Pressure Among Causes of Intracerebral Hemorrhage
Lin J, Piran P, Lerario MP, Ong H, Gupta A, Murthy SB, Díaz I, Stieg PE, Knopman J, Falcone GJ, Sheth KN, Fink ME, Merkler AE, Kamel H. Differences in Admission Blood Pressure Among Causes of Intracerebral Hemorrhage. Stroke 2019, 51: 644-647. PMID: 31818231, PMCID: PMC9578686, DOI: 10.1161/strokeaha.119.028009.Peer-Reviewed Original ResearchConceptsAdmission systolic blood pressureSystolic blood pressureGlasgow Coma Scale scoreIntracerebral hemorrhageHypertensive intracerebral hemorrhageBlood pressureHematoma sizeScale scoreCornell Acute Stroke Academic RegistryAdmission blood pressureStructural vascular lesionsHours of hospitalizationPanel of neurologistsAdmission BPAntihypertensive agentsEmergency departmentMixed-effects linear modelVascular lesionsSBP measurementsSecondary analysisAcademic RegistryHospitalizationHemorrhagePatientsAdmission
2018
Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage
Murphy MP, Kuramatsu JB, Leasure A, Falcone GJ, Kamel H, Sansing LH, Kourkoulis C, Schwab K, Elm JJ, Gurol ME, Tran H, Greenberg SM, Viswanathan A, Anderson CD, Schwab S, Rosand J, Shi FD, Kittner SJ, Testai FD, Woo D, Langefeld CD, James ML, Koch S, Huttner HB, Biffi A, Sheth KN. Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage. Stroke 2018, 49: 2652-2658. PMID: 30355194, PMCID: PMC6211810, DOI: 10.1161/strokeaha.118.021799.Peer-Reviewed Original ResearchConceptsCardioembolic stroke riskOral anticoagulation therapyRankin Scale scoreIntracerebral hemorrhageFunctional recoveryStroke riskAnticoagulation resumptionVASc scoreRecurrent strokeAnticoagulation therapyScale scoreAnticoagulation-related intracerebral hemorrhageDecreased likelihoodSurvivors of ICHModified Rankin Scale scoreNonvalvular atrial fibrillationRecurrent intracerebral hemorrhageOral anticoagulation treatmentICH survivorsTherapy resumptionAnticoagulation treatmentCardioembolic strokeIschemic strokeAtrial fibrillationIndex event