2021
Association of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral Hemorrhage
Leasure AC, Kuohn LR, Vanent KN, Bevers MB, Kimberly WT, Steiner T, Mayer SA, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Association of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral Hemorrhage. Stroke 2021, 52: 1733-1740. PMID: 33682454, PMCID: PMC8085132, DOI: 10.1161/strokeaha.120.032888.Peer-Reviewed Original ResearchConceptsIL-6 levelsPerihematomal edema volumeIntracerebral hemorrhageIL-6Edema volumeFunctional outcomeICH locationICH volumeTreatment groupsSerum IL-6 levelsBaseline ICHAcute brain injuryLarge intracerebral hemorrhageSerum IL-6Predictors of outcomeSpontaneous intracerebral hemorrhageRankin ScalePoor outcomeProinflammatory cytokinesTrial populationBrain injurySecondary analysisStrong associationFast trialsOutcomes
2020
Prior antiplatelet therapy and haematoma expansion after primary intracerebral haemorrhage: an individual patient-level analysis of CLEAR III, MISTIE III and VISTA-ICH
Murthy S, Roh DJ, Chatterjee A, McBee N, Parikh NS, Merkler AE, Navi BB, Falcone GJ, Sheth KN, Awad I, Hanley D, Kamel H, Ziai WC. Prior antiplatelet therapy and haematoma expansion after primary intracerebral haemorrhage: an individual patient-level analysis of CLEAR III, MISTIE III and VISTA-ICH. Journal Of Neurology Neurosurgery & Psychiatry 2020, 92: 364-369. PMID: 33106367, PMCID: PMC8071838, DOI: 10.1136/jnnp-2020-323458.Peer-Reviewed Original ResearchPrior antiplatelet therapyAntiplatelet therapyLobar intracerebral hemorrhageIntracerebral hemorrhagePrimary intracerebral hemorrhageHaematoma expansionHaematoma volumeHaematoma locationCause mortalityIII trialsStudy cohortMajor disabilitySecondary analysisIndividual patient-level analysisPhase III trialsLarge heterogeneous cohortIndividual patient dataPatient-level analysisMISTIE IIISecondary outcomesDeep hemorrhagesPrimary outcomeICH locationMRS distributionFunctional outcomeRace/ethnicity influences outcomes in young adults with supratentorial intracerebral hemorrhage.
Miyares LC, Falcone GJ, Leasure A, Adeoye O, Shi FD, Kittner SJ, Langefeld C, Vagal A, Sheth KN, Woo D. Race/ethnicity influences outcomes in young adults with supratentorial intracerebral hemorrhage. Neurology 2020, 94: e1271-e1280. PMID: 31969467, PMCID: PMC7274930, DOI: 10.1212/wnl.0000000000008930.Peer-Reviewed Original ResearchConceptsSupratentorial intracerebral hemorrhageModified Rankin ScaleIntracerebral hemorrhageRace/ethnicityFunctional outcomeYounger patientsPoor outcomeAdmission Glasgow Coma Scale scoreEthnic/Racial VariationsGlasgow Coma Scale scoreHispanic participantsHispanic race/ethnicityAdmission blood pressureDeep ICH locationIntracerebral Hemorrhage (ERICH) studyProspective multicenter studyGood functional outcomeNon-Hispanic blacksBaseline disabilityRankin ScaleBlood pressureICH locationIntraventricular extensionMulticenter studyICH volume
2014
Risk Factors for Computed Tomography Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage Are Shared
Radmanesh F, Falcone GJ, Anderson CD, Battey TW, Ayres AM, Vashkevich A, McNamara KA, Schwab K, Romero JM, Viswanathan A, Greenberg SM, Goldstein JN, Rosand J, Brouwers HB. Risk Factors for Computed Tomography Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage Are Shared. Stroke 2014, 45: 1833-1835. PMID: 24876264, PMCID: PMC4116606, DOI: 10.1161/strokeaha.114.005276.Peer-Reviewed Original ResearchConceptsLobar intracerebral hemorrhageComputed tomography angiographyBaseline ICH volumeIntracerebral hemorrhagePrimary intracerebral hemorrhageSpot signTomography angiographyICH locationICH volumeMultivariable regressionChronic cerebral small vessel diseaseCerebral small vessel diseaseDeep intracerebral hemorrhageSmall vessel diseaseTomography angiography spot signLobar ICH patientsComputed tomography angiography spot signAvailable computed tomography angiographySpot sign presenceSymptom onsetICH patientsPoor outcomeVessel diseaseAcute manifestationsHematoma expansion
2013
Predictors of Hematoma Volume in Deep and Lobar Supratentorial Intracerebral Hemorrhage
Falcone GJ, Biffi A, Brouwers HB, Anderson CD, Battey TW, Ayres AM, Vashkevich A, Schwab K, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Rosand J. Predictors of Hematoma Volume in Deep and Lobar Supratentorial Intracerebral Hemorrhage. JAMA Neurology 2013, 70: 988-994. PMID: 23733000, PMCID: PMC3808840, DOI: 10.1001/jamaneurol.2013.98.Peer-Reviewed Original ResearchConceptsLobar intracerebral hemorrhageIntensity of anticoagulationIntracerebral hemorrhageICH volumeHematoma volumeIndependent predictorsLobar supratentorial intracerebral haemorrhageProspective cohort studyCoronary artery diseaseSupratentorial intracerebral hemorrhageMedian ICH volumePrimary ICH patientsComputed tomography scanMultivariable linear regressionAcademic medical centerIntracerebral hemorrhage volumeLobar hemorrhageAntiplatelet treatmentRadiological outcomesArtery diseaseCohort studyDeep hemorrhagesICH locationICH patientsMale sex
2012
Confounding by Indication in Retrospective Studies of Intracerebral Hemorrhage: Antiepileptic Treatment and Mortality
Battey TW, Falcone GJ, Ayres AM, Schwab K, Viswanathan A, McNamara KA, DiPucchio ZY, Greenberg SM, Sheth KN, Goldstein JN, Rosand J. Confounding by Indication in Retrospective Studies of Intracerebral Hemorrhage: Antiepileptic Treatment and Mortality. Neurocritical Care 2012, 17: 361-366. PMID: 22965324, PMCID: PMC3707622, DOI: 10.1007/s12028-012-9776-z.Peer-Reviewed Original ResearchConceptsIntroductionIntracerebral hemorrhageAED treatmentAntiepileptic drugsCohort of patientsAntiepileptic treatmentRankin scoreICH locationIntracerebral hemorrhageRetrospective studyHemorrhage locationClinicians' decisionsResultsMultivariate analysisRetrospective analysisSupratentorial regionFatal diseaseConclusionThese resultsMortalityPatientsConflicting resultsTreatmentTreatment effectsHemorrhageCohortAssociationAdequate power