2021
Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset
Witsch J, Falcone GJ, Leasure AC, Matouk C, Endres M, Sansing L, Woo D, Sheth KN. Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset. Neurocritical Care 2021, 35: 418-427. PMID: 33479920, PMCID: PMC8578176, DOI: 10.1007/s12028-020-01180-2.Peer-Reviewed Original ResearchConceptsLoss of consciousnessIntraventricular hemorrhageIntracerebral hemorrhageSymptom onsetICH onsetUnfavorable outcomeAdmission Glasgow Coma ScoreAdmission systolic blood pressureOnset of ICHGlasgow Coma ScoreSystolic blood pressureSpontaneous intracerebral hemorrhageAdmission serum glucoseThousand seven hundredVolumetric CT measurementsBackgroundIn patientsComa ScoreBlood pressureMedical chartsICH volumeMental statusSerum glucoseICH casesInclusion criteriaPatients
2020
Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage
Falcone GJ, Kirsch E, Acosta JN, Noche RB, Leasure A, Marini S, Chung J, Selim M, Meschia JF, Brown DL, Worrall BB, Tirschwell DL, Jagiella JM, Schmidt H, Jimenez‐Conde J, Fernandez‐Cadenas I, Lindgren A, Slowik A, Gill D, Holmes M, Phuah C, Petersen NH, Matouk CN, Gunel M, Sansing L, Bennett D, Chen Z, Sun LL, Clarke R, Walters RG, Gill TM, Biffi A, Kathiresan S, Langefeld CD, Woo D, Rosand J, Sheth KN, Anderson CD, Consortium F. Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage. Annals Of Neurology 2020, 88: 56-66. PMID: 32277781, PMCID: PMC7523882, DOI: 10.1002/ana.25740.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhagePolygenic risk scoresLDL cholesterolLower riskTotal cholesterolICH riskLow-density lipoprotein cholesterol levelsRisk of ICHLipoprotein cholesterol levelsPotential causal roleMendelian randomization analysisAnn NeurolLDL levelsCholesterol levelsICH casesObservational studySD increaseSignificant single nucleotide polymorphismsRisk scoreSignificant associationCholesterolMR analysisInverse correlationRandomization analysisSingle nucleotide polymorphisms
2019
Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity
Marini S, Crawford K, Morotti A, Lee MJ, Pezzini A, Moomaw CJ, Flaherty ML, Montaner J, Roquer J, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano-Tarraga C, Slowik A, Jagiella JM, Pera J, Urbanik A, Pichler A, Hansen BM, McCauley JL, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Testai FD, Kittner SJ, Schmidt H, Enzinger C, Deary IJ, Rannikmae K, Samarasekera N, Salman RA, Sudlow CL, Klijn CJM, van Nieuwenhuizen KM, Fernandez-Cadenas I, Delgado P, Norrving B, Lindgren A, Goldstein JN, Viswanathan A, Greenberg SM, Falcone GJ, Biffi A, Langefeld CD, Woo D, Rosand J, Anderson CD. Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity. JAMA Neurology 2019, 76: 480-491. PMID: 30726504, PMCID: PMC6459133, DOI: 10.1001/jamaneurol.2018.4519.Peer-Reviewed Original ResearchConceptsRace/ethnicityIntracerebral hemorrhageICH riskPotent genetic risk factorApolipoprotein E (APOE) ε4 alleleAPOE allele statusBurden of hypertensionPopulation-based studyPrimary intracerebral hemorrhageIntracerebral hemorrhage riskCase-control studyAssociation of APOEPropensity score analysisGenetic risk factorsWhite participantsRace/ethnic groupsHypertension burdenHemorrhage riskClinical variablesInternational Stroke Genetics ConsortiumRisk factorsSecondary causesΕ2 alleleICH casesApolipoprotein E
2014
Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage
Woo D, Falcone GJ, Devan WJ, Brown WM, Biffi A, Howard TD, Anderson CD, Brouwers HB, Valant V, Battey TW, Radmanesh F, Raffeld MR, Baedorf-Kassis S, Deka R, Woo JG, Martin LJ, Haverbusch M, Moomaw CJ, Sun G, Broderick JP, Flaherty ML, Martini SR, Kleindorfer DO, Kissela B, Comeau ME, Jagiella JM, Schmidt H, Freudenberger P, Pichler A, Enzinger C, Hansen BM, Norrving B, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, Roquer J, Kraft P, Ayres AM, Schwab K, McCauley JL, Pera J, Urbanik A, Rost NS, Goldstein JN, Viswanathan A, Stögerer EM, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernandez-Cadenas I, Delgado P, Malik R, Dichgans M, Greenberg SM, Rothwell PM, Lindgren A, Slowik A, Schmidt R, Langefeld CD, Rosand J, Consortium T. Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage. American Journal Of Human Genetics 2014, 94: 511-521. PMID: 24656865, PMCID: PMC3980413, DOI: 10.1016/j.ajhg.2014.02.012.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageControl cohortCase cohortRisk of ICHUnderlying vascular pathologyLobar intracerebral hemorrhageNonlobar intracerebral hemorrhageRandom digit dialingRuptured blood vesselsReplication of signalsStroke subtypesAcute treatmentWorse prognosisControl subjectsAmbulatory clinicsICH casesMeta-analyzed dataVascular pathologyDiscovery cohortCase subjectsSusceptibility lociCohortICH subtypesBlood vesselsNonlobar
2013
Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage
Woo D, Deka R, Falcone GJ, Flaherty ML, Haverbusch M, Martini SR, Greenberg SM, Ayres AM, Sauerbeck L, Kissela BM, Kleindorfer DO, Moomaw CJ, Anderson CD, Broderick JP, Rosand J, Langefeld CD, Woo JG. Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage. Stroke 2013, 44: 3013-3017. PMID: 24008570, PMCID: PMC3873717, DOI: 10.1161/strokeaha.113.001304.Peer-Reviewed Original ResearchConceptsRisk of ICHLobar intracerebral hemorrhageStatin useIntracerebral hemorrhageReplication cohortICH casesAssociation of hypercholesterolemiaHemorrhagic Stroke studyNonlobar intracerebral hemorrhageCase-control studyApolipoprotein E genotypeFisher's exact testEnvironmental risk factorsBreslow-Day testHemorrhagic strokeStroke StudyRisk factorsClinical changesE4 genotypeAPOE polymorphismE genotypeApolipoprotein EDiscovery cohortHigh riskLower riskWarfarin and Statins are Associated with Hematoma Volume in Primary Infratentorial Intracerebral Hemorrhage
Falcone GJ, Brouwers HB, Biffi A, Anderson CD, Battey TW, Ayres AM, Vashkevich A, Schwab KM, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Rosand J. Warfarin and Statins are Associated with Hematoma Volume in Primary Infratentorial Intracerebral Hemorrhage. Neurocritical Care 2013, 21: 192-199. PMID: 23839705, PMCID: PMC4107188, DOI: 10.1007/s12028-013-9839-9.Peer-Reviewed Original ResearchConceptsInfratentorial intracerebral hemorrhageIntracerebral hemorrhageICH volumeSurgical evacuationHematoma volumeBrainstem ICHSingle-center studySupratentorial intracerebral hemorrhageWarfarin treatmentStatin treatmentEmergency departmentICH casesRetrospective analysisCT scanLogistic regressionWarfarinICH subjectsLimited dataHemorrhageStatinsFurther studiesComputer-assisted methodTreatmentInverse relationLinear regression
2012
Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage
Falcone GJ, Biffi A, Devan WJ, Jagiella JM, Schmidt H, Kissela B, Hansen BM, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, Ayres AM, Schwab K, Pera J, Urbanik A, Rost NS, Goldstein JN, Viswanathan A, Pichler A, Enzinger C, Norrving B, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernandez-Cadenas I, Delgado P, Broderick JP, Greenberg SM, Roquer J, Lindgren A, Slowik A, Schmidt R, Flaherty ML, Kleindorfer DO, Langefeld CD, Woo D, Rosand J. Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage. Stroke 2012, 43: 2877-2883. PMID: 22933587, PMCID: PMC3479325, DOI: 10.1161/strokeaha.112.659755.Peer-Reviewed Original ResearchConceptsRisk of ICHBlood pressure levelsIntracerebral hemorrhageGenetic risk scoreUnweighted genetic risk scoreRisk scoreProspective multicenter case-control studyMulticenter case-control studyHistory of hypertensionLobar intracerebral hemorrhageDeep intracerebral hemorrhagePotent risk factorCase-control studyLogistic regression modelsControl subjectsRisk factorsICH casesHypertensionIncrease riskCumulative burden