2023
Neighborhood Deprivation and Race Synergistically Contribute to Undiagnosed Hypertension Leading to Acute Ischemic Stroke: Results from the All of Us Research Program (P6-9.001)
Torres-Lopez V, Renedo D, Acosta J, Gill T, Sheth K, Falcone G, Rivier C. Neighborhood Deprivation and Race Synergistically Contribute to Undiagnosed Hypertension Leading to Acute Ischemic Stroke: Results from the All of Us Research Program (P6-9.001). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202154.Peer-Reviewed Original ResearchPolygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors
Acosta J, Both C, Demarais Z, Conlon C, Leasure A, Torres-Lopez V, de Havenon A, Petersen N, Gill T, Sansing L, Sheth K, Falcone G. Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors. Neurology 2023, 100: e1587-e1597. PMID: 36690452, PMCID: PMC10103110, DOI: 10.1212/wnl.0000000000206763.Peer-Reviewed Original ResearchConceptsWorse BP controlUncontrolled blood pressureDiastolic blood pressureBlood pressureStroke survivorsPolygenic risk scoresBP controlPolygenic susceptibilityMean diastolic blood pressureMean systolic blood pressureStroke Prevention TrialBlood pressure controlSystolic blood pressureResistant hypertensionVascular eventsHemorrhagic strokePrevention trialsVitamin InterventionMultivariable modelRisk scoreGenetic predispositionPressure controlLogistic regressionSurvivorsHypertension
2021
Real-Time Imaging of Aneurysmal Rupture Causing an Isolated Acute Subdural Hematoma
Hong C, Renedo D, Sujijantarat N, Koo A, Falcone GJ, Malhotra A, Petersen NH, Matouk C. Real-Time Imaging of Aneurysmal Rupture Causing an Isolated Acute Subdural Hematoma. Neurology 2021, 98: 373-374. PMID: 34937782, PMCID: PMC10508646, DOI: 10.1212/wnl.0000000000013251.Peer-Reviewed Original ResearchConceptsAcute subdural hematomaSubdural hematomaRight cranial nerve III palsyCranial nerve III palsyIsolated Acute Subdural HematomaEmergent decompressive craniectomyEmergency department evaluationDecompressive craniectomyDepartment evaluationArtery aneurysmPostoperative imagingAneurysmal ruptureHematomaMRI scannerImagingHypertensionPalsyHeadacheCraniectomyAneurysmsReal-time imagingMRIWomenPolygenic Susceptibility to Hypertension is Associated with Uncontrolled and Resistant Hypertension in Stroke Survivors (1838)
Acosta J, Both C, Szejko N, Brown S, Petersen N, Sansing L, Sheth K, Falcone G. Polygenic Susceptibility to Hypertension is Associated with Uncontrolled and Resistant Hypertension in Stroke Survivors (1838). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.1838.Peer-Reviewed Original Research
2012
Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage
Falcone GJ, Biffi A, Devan WJ, Jagiella JM, Schmidt H, Kissela B, Hansen BM, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, Ayres AM, Schwab K, Pera J, Urbanik A, Rost NS, Goldstein JN, Viswanathan A, Pichler A, Enzinger C, Norrving B, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernandez-Cadenas I, Delgado P, Broderick JP, Greenberg SM, Roquer J, Lindgren A, Slowik A, Schmidt R, Flaherty ML, Kleindorfer DO, Langefeld CD, Woo D, Rosand J. Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage. Stroke 2012, 43: 2877-2883. PMID: 22933587, PMCID: PMC3479325, DOI: 10.1161/strokeaha.112.659755.Peer-Reviewed Original ResearchConceptsRisk of ICHBlood pressure levelsIntracerebral hemorrhageGenetic risk scoreUnweighted genetic risk scoreRisk scoreProspective multicenter case-control studyMulticenter case-control studyHistory of hypertensionLobar intracerebral hemorrhageDeep intracerebral hemorrhagePotent risk factorCase-control studyLogistic regression modelsControl subjectsRisk factorsICH casesHypertensionIncrease riskCumulative burden