2018
Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose
Ye Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C. Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose. Physics In Medicine And Biology 2018, 63: 175015. PMID: 30095083, PMCID: PMC6158045, DOI: 10.1088/1361-6560/aad97f.Peer-Reviewed Original ResearchConceptsPopulation-based input functionStandardized uptake valueImage-derived input functionLung nodulesClinical trialsTime-activity curvesLow-dose computed tomography (LDCT) screeningLung cancer mortality ratesIndeterminate lung nodulesComputed Tomography ScreeningF-FDG PETCancer mortality ratesStatic PET acquisitionVirtual clinical trialsScan durationTomography screeningFDG injectionPET scansMortality rateUptake valueAccurate diagnosisMalignant lung nodulesROC analysisPatient dataMalignant nodules
2013
Enhancing clinical utility of respiratory-gated PET/CT using patient respiratory trace classification
Bowen S, Pierce L, Alessio A, Liu C, Kinahan P. Enhancing clinical utility of respiratory-gated PET/CT using patient respiratory trace classification. 2011 IEEE Nuclear Science Symposium Conference Record 2013, 2881-2885. DOI: 10.1109/nssmic.2012.6551657.Peer-Reviewed Original ResearchLesion locationDiagnostic CTMaximum standardized uptake valueUpper lung lesionSelection of patientsPatient selection guidelinesStandardized uptake valueLiver cancer patientsPET/CTPET/CT examsLower lungPatient groupCancer patientsLung lesionsPET parametersClinical utilityLiver lesionsResponse assessmentPatientsPET imagesUptake valueCT examsLinear associationAbdominal displacementCT