2010
Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor
Cardenas I, Means RE, Aldo P, Koga K, Lang SM, Booth C, Manzur A, Oyarzun E, Romero R, Mor G. Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor. The Journal Of Immunology 2010, 185: 1248-1257. PMID: 20554966, PMCID: PMC3041595, DOI: 10.4049/jimmunol.1000289.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial InfectionsCell LineCells, CulturedCytokinesFemaleFetal DiseasesFetusHost-Pathogen InteractionsHumansImmunohistochemistryInflammationMaternal-Fetal ExchangeMiceMice, Inbred C57BLMice, KnockoutNIH 3T3 CellsObstetric Labor, PrematurePlacentaPlacenta DiseasesPregnancyPregnancy Complications, InfectiousRhadinovirusToll-Like Receptor 3Virus DiseasesConceptsViral infectionPreterm laborBacterial productsFetal inflammatory responseMaternal immune systemFetal transmissionFetal inflammationNonpregnant populationOrgan damagePregnant womenPregnant mothersPlacental unitInflammatory responseImmunological roleAnimal modelsImmune systemInfectionPlacentaMicrobial infectionsFetusesDevelopmental deficienciesMothersDetrimental effectsPandemicInflammation
2007
Fetal nucleated red blood cells in a rat model of intrauterine growth restriction induced by hypoxia and nitric oxide synthase inhibition
Ravishankar V, Buhimschi CS, Booth CJ, Bhandari V, Norwitz E, Copel J, Buhimschi IA. Fetal nucleated red blood cells in a rat model of intrauterine growth restriction induced by hypoxia and nitric oxide synthase inhibition. American Journal Of Obstetrics And Gynecology 2007, 196: 482.e1-482.e8. PMID: 17466713, DOI: 10.1016/j.ajog.2006.12.020.Peer-Reviewed Original ResearchConceptsIntrauterine growth restrictionNucleated red blood cellsNitric oxide inhibitionFetal nucleated red blood cellsChronic hypoxiaL-NAMEErythropoietin levelsOxide inhibitionRed blood cellsFetal circulationGrowth restrictionFetal bloodHematocrit levelsNumber of NRBCsNitro-L-arginine methyl esterChronic nitric oxide inhibitionMaternal acid-base statusNitric oxide synthase inhibitionBlood cellsMaternal arterial blood gasesOxide synthase inhibitionArterial blood gasesSaline solutionAdult Sprague-DawleyElevated erythropoietin levels