2024
To Face Transplant or Not Face Transplant? Evaluating the Limitations of ChatGPT's Consideration of Ethical Themes
Boroumand S, Gu E, Huelsboemer L, Stögner V, Parikh N, Kauke-Navarro M, Pomahac B. To Face Transplant or Not Face Transplant? Evaluating the Limitations of ChatGPT's Consideration of Ethical Themes. Annals Of Plastic Surgery 2024, 93: 527-529. PMID: 39331750, DOI: 10.1097/sap.0000000000004072.Peer-Reviewed Original Research
2023
Insights from immunoproteomic profiling of a rejected full-face transplant
Lee C, Wang D, Kauke-Navarro M, Russell-Goldman E, Xu S, Mucciarone K, Sohrabi S, Lian C, Pomahac B, Murphy G. Insights from immunoproteomic profiling of a rejected full-face transplant. American Journal Of Transplantation 2023, 23: 1058-1061. PMID: 37037378, DOI: 10.1016/j.ajt.2023.04.008.Peer-Reviewed Original ResearchMeSH KeywordsComposite Tissue AllograftsFacial TransplantationGraft RejectionGraft SurvivalProteomicsVascularized Composite AllotransplantationConceptsVascularized Composite AllograftsT cellsChronic rejectionCD8-positive T cellsEffector T cellsFull face transplantArteriosclerotic alterationsIntragraft arteriesVCA rejectionGraft arteryAccelerated arteriosclerosisRecipient originPunch biopsyAtherogenic responseComposite allograftsImmunoproteomic profilingDioxygenase 1Target endotheliumArteryEndotheliumProteomic profilingPathway componentsCellsRejectionAllograftsLow-dose interleukin-2 promotes immune regulation in face transplantation: A pilot study
Murakami N, Borges T, Win T, Abarzua P, Tasigiorgos S, Kollar B, Barrera V, Ho Sui S, Teague J, Bueno E, Clark R, Lian C, Murphy G, Pomahac B, Riella L. Low-dose interleukin-2 promotes immune regulation in face transplantation: A pilot study. American Journal Of Transplantation 2023, 23: 549-558. PMID: 36740193, PMCID: PMC10318113, DOI: 10.1016/j.ajt.2023.01.016.Peer-Reviewed Original ResearchMeSH KeywordsFacial TransplantationGraft RejectionHumansInterleukin-2Pilot ProjectsT-Lymphocytes, RegulatoryConceptsLow-dose IL-2 therapyIL-2 therapySkin allograftsFace transplant recipientsTransplant recipientsIL-2Immune regulationLow-dose interleukin-2 (IL-2) therapyHigher acute rejection ratesLow-dose IL-2Face transplantationAcute rejection ratesCytotoxicity-associated genesDose interleukin-2Greater suppressive functionInterleukin-2 therapyAutoimmune hemolytic anemiaRegulatory T cellsNarrow therapeutic windowLife-changing procedureImmunological monitoringTim-3Peripheral bloodImmune modulationHemolytic anemiaFacial Expression after Face Transplant: An International Face Transplant Cohort Comparison
Dorante M, Wang A, Kollar B, Perry B, Ertosun M, Lindford A, Kiukas E, Özkan Ö, Özkan Ö, Lassus P, Pomahac B. Facial Expression after Face Transplant: An International Face Transplant Cohort Comparison. Plastic & Reconstructive Surgery 2023, 152: 315e-325e. PMID: 36727808, DOI: 10.1097/prs.0000000000010242.Peer-Reviewed Original ResearchMeSH KeywordsFacial ExpressionFacial NerveFacial ParalysisFacial TransplantationFemaleHumansMaleSmilingSoftwareConceptsFT patientsHealthy controlsMotor function restorationMotor functionFace transplantFunction restorationAge-matched healthy controlsCLINICAL QUESTION/LEVELInterpositional nerve graftFull face transplantRespective healthy controlsMotor outcomeNerve coaptationFemale patientsNerve graftsPatientsPercentage restorationCohort comparisonFacial proceduresBilateral testsTransplantScore valuesFacial movements
2022
Longitudinal Recovery of Speech Motor Function Following Facial Transplantation: A Prospective Observational Study
Perry B, Eshghi M, Stipancic K, Richburg B, Ventresca H, Pomahac B, Green J. Longitudinal Recovery of Speech Motor Function Following Facial Transplantation: A Prospective Observational Study. The Laryngoscope 2022, 132: 2359-2367. PMID: 35218215, PMCID: PMC9402794, DOI: 10.1002/lary.30068.Peer-Reviewed Original ResearchConceptsFunctional speechSpeech intelligibilitySpeech recoveryLip strengthSpeech motor functionSpeech outcomesSentence intelligibility testMotor speech functionKinematic measuresProspective observational studyFacial transplantationRange of movementIntelligibility testIntelligibility improvementJaw rangeLongitudinal recoveryMotor functionObservational studyClinical measuresEarly recoveryJaw functionExtent of recoverySpeech functionSpeech improvementPatients
2021
Visual Release Hallucinations After Facial Allotransplantation
Gibbons L, Gitlin D, Erkkinen M, Kolodziej M, Pomahac B, McComiskey K, Shah S. Visual Release Hallucinations After Facial Allotransplantation. Harvard Review Of Psychiatry 2021, 29: 327-334. PMID: 34033593, DOI: 10.1097/hrp.0000000000000296.Peer-Reviewed Original ResearchImmunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection
Win T, Crisler W, Dyring-Andersen B, Lopdrup R, Teague J, Zhan Q, Barrera V, Sui S, Tasigiorgos S, Murakami N, Chandraker A, Tullius S, Pomahac B, Riella L, Clark R. Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection. Journal Of Clinical Investigation 2021, 131 PMID: 33667197, PMCID: PMC8262560, DOI: 10.1172/jci135166.Peer-Reviewed Original ResearchConceptsVCA rejectionTransplant rejectionT cellsTissue injuryGene expression profilingAntigen-presenting cell activationT-cell receptor sequencingSolid organ transplantsCell receptor sequencingT cell activation pathwaysAntigen-specific activationProliferative T cellsCell activation pathwaysNovo Nordisk FoundationAmerican SocietyExpression profilingFace transplant patientsTransplant patientsImmunologic pathwaysImmunoregulatory networkSkin biopsiesImmunomodulatory pathwaysLimb transplantsLundbeck FoundationTransplant Research
2020
Indications for and Outcomes of Endoscopic Sinus Surgery and Other Rhinologic Surgery After Facial Transplant
Haug V, Yamasaki A, Fullerton Z, Maxfield A, Pomahac B, Bergmark R, Annino D. Indications for and Outcomes of Endoscopic Sinus Surgery and Other Rhinologic Surgery After Facial Transplant. JAMA Otolaryngology - Head & Neck Surgery 2020, 146: 669-671. PMID: 32525516, PMCID: PMC7290693, DOI: 10.1001/jamaoto.2020.0774.Peer-Reviewed Original ResearchCirculating Donor-derived Cell-free DNA as a Biomarker in Vascularized Composite Allotransplantation?
Haug V, Kuang Y, Tasigiorgos S, Kollar B, Mogili A, Jänne P, Talbot S, Paweletz C, Pomahac B. Circulating Donor-derived Cell-free DNA as a Biomarker in Vascularized Composite Allotransplantation? Transplantation 2020, 104: e79-e80. PMID: 31596743, DOI: 10.1097/tp.0000000000003000.Peer-Reviewed Original ResearchRecognizing Emotional Expression as an Outcome Measure After Face Transplant
Dorante M, Kollar B, Obed D, Haug V, Fischer S, Pomahac B. Recognizing Emotional Expression as an Outcome Measure After Face Transplant. JAMA Network Open 2020, 3: e1919247. PMID: 31940037, PMCID: PMC6991259, DOI: 10.1001/jamanetworkopen.2019.19247.Peer-Reviewed Original Research
2019
The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation
Haug V, Kollar B, Obed D, Kiwanuka H, Turk M, Wo L, Tasigiorgos S, Kueckelhaus M, Riella L, Pomahac B. The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation. Facial Plastic Surgery & Aesthetic Medicine 2019, 21: 278-285. PMID: 30998810, PMCID: PMC6646986, DOI: 10.1001/jamafacial.2019.0076.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiopsyDiagnosis, DifferentialErythemaExanthemaFacial TransplantationFemaleFollow-Up StudiesGraft RejectionHumansImmunosuppressive AgentsMaleMiddle AgedConceptsAcute rejectionSubtherapeutic tacrolimus levelsClinical signsRejection episodesImmunosuppressive therapySubclinical rejectionTacrolimus levelsMedical recordsOdds ratioFacial transplantationDiagnostic valueSignificant associationSingle-center cohort studyLate rejection episodesProtocol skin biopsiesSecond posttransplant yearSymptoms of rejectionTacrolimus blood levelsSecond postoperative yearReliable clinical signFull facial transplantationPostoperative yearPosttransplant yearYears posttransplantationAllograft rejectionFive-Year Follow-up after Face Transplantation
Tasigiorgos S, Kollar B, Turk M, Perry B, Alhefzi M, Kiwanuka H, Nizzi M, Marty F, Chandraker A, Tullius S, Riella L, Pomahac B. Five-Year Follow-up after Face Transplantation. New England Journal Of Medicine 2019, 380: 2579-2581. PMID: 31141626, DOI: 10.1056/nejmc1810468.Peer-Reviewed Original ResearchMeSH KeywordsAdultFaceFacial TransplantationFollow-Up StudiesGraft RejectionHumansImmunosuppression TherapyInfectionsMiddle AgedPostoperative Complications
2018
Chronic rejection of human face allografts
Krezdorn N, Lian C, Wells M, Wo L, Tasigiorgos S, Xu S, Borges T, Frierson R, Stanek E, Riella L, Pomahac B, Murphy G. Chronic rejection of human face allografts. American Journal Of Transplantation 2018, 19: 1168-1177. PMID: 30312535, PMCID: PMC6433509, DOI: 10.1111/ajt.15143.Peer-Reviewed Original ResearchMeSH KeywordsAdultChronic DiseaseComposite Tissue AllograftsFacial TransplantationFemaleGene Expression ProfilingGraft RejectionHumansImmunosuppressive AgentsMaleMiddle AgedConceptsChronic rejectionComposite allograftsAutoimmune cutaneous disordersImmune-mediated changesLymphocyte-mediated cytotoxicityC-fosSevere facial disfigurementType IAcute rejectionSurveillance biopsiesIatrogenic immunosuppressionVascular ectasiaFollicular pluggingSystemic sclerosisHistopathologic evidenceClinical manifestationsPreventative therapyCutaneous disordersGraft durabilityFace allograftNasal mucosaPathologic changesPathologic alterationsEpidermal thinningSclerotic zoneIncreased levels of circulating MMP3 correlate with severe rejection in face transplantation
Kollar B, Shubin A, Borges T, Tasigiorgos S, Win T, Lian C, Dillon S, Gu X, Wyrobnik I, Murphy G, Pomahac B, Libermann T, Riella L. Increased levels of circulating MMP3 correlate with severe rejection in face transplantation. Scientific Reports 2018, 8: 14915. PMID: 30297859, PMCID: PMC6175842, DOI: 10.1038/s41598-018-33272-7.Peer-Reviewed Original ResearchConceptsSevere rejectionFace transplantationLarge independent patient cohortsAcute rejection episodesAnti-rejection treatmentFirst postoperative yearLongitudinal serum samplesNon-invasive candidate biomarkersViable treatment optionSOMAscan proteomics platformIndependent patient cohortsFace transplant recipientsRejection episodesPostoperative yearTransplant recipientsDevastating injuriesMMP3 levelsTransplant rejectionHistological gradePatient cohortTreatment optionsSurrogate markerMMP3 proteinCandidate biomarkersTransplantationPediatric face transplantation
Dorante M, Tasigiorgos S, Pomahac B. Pediatric face transplantation. Current Opinion In Organ Transplantation 2018, 23: 598-604. PMID: 30080696, DOI: 10.1097/mot.0000000000000572.Peer-Reviewed Original ResearchConceptsFace transplantationPediatric hand transplantationImmunosuppression burdenRejection episodesDonor allograftsPatient demographicsPediatric patientsAppropriate patientsHand transplantationHand transplantTransplantationPediatric colleaguesPatientsYoung populationFace transplantSurgical innovationTransplantOutcomesSoftware‐based video analysis of functional outcomes of face transplantation
Fischer S, Diehm Y, Dorante M, Kotsougiani D, Kueckelhaus M, Alhefzi M, Bueno E, Pomahac B. Software‐based video analysis of functional outcomes of face transplantation. Microsurgery 2018, 39: 53-61. PMID: 30159931, DOI: 10.1002/micr.30360.Peer-Reviewed Original ResearchConceptsFace transplantationNormal populationAssessment of outcomesDifferent time pointsFunctional outcomeFacial movementsPatient's abilitySame patientTransplantationMouth openingOutcome assessmentPatientsValuable assessment toolOpen mouthEye closureTime pointsRetrospective assessmentMonthsLip purseFacial transplantationAssessment toolSound evidenceOutcomesNoseEyebrowsTrismus in Face Transplantation Following Ballistic Trauma
Krezdorn N, Alhefzi M, Perry B, Aycart M, Tasigiorgos S, Bueno E, Green J, Pribaz J, Pomahac B, Caterson E. Trismus in Face Transplantation Following Ballistic Trauma. Journal Of Craniofacial Surgery 2018, 29: 843-847. PMID: 29381613, DOI: 10.1097/scs.0000000000004271.Peer-Reviewed Original ResearchMeSH KeywordsAdultFaceFacial TransplantationHumansMalePlastic Surgery ProceduresPostoperative ComplicationsRange of Motion, ArticularTrismusWounds, GunshotConceptsFace transplant recipientsTemporomandibular jointFace transplantationTransplant recipientsFunctional outcomeBallistic traumaMouth openingImpaired mouth openingOral food intakeImmediate postoperative periodBallistic injuriesRange of motionPartial face transplantationCovert injuriesIntraoperative releasePersistent trismusTotal condylectomyYear posttransplantPostoperative periodPostoperative planningPostoperative treatmentPrimary injuryIntraoperative evaluationSevere scarringMedical recordsQuality of Life and Psychosocial Functioning 2 Years Following Facial Transplantation
Oser M, Nizzi M, Zinser J, Turk M, Epstein R, Bueno E, Gitlin D, Pomahac B. Quality of Life and Psychosocial Functioning 2 Years Following Facial Transplantation. Journal Of The Academy Of Consultation-Liaison Psychiatry 2018, 59: 591-600. PMID: 29861176, DOI: 10.1016/j.psym.2018.04.005.Peer-Reviewed Original ResearchConceptsPhysical health QoLDepressive symptomsHealth statusPhysical health-related QoLFace transplantationOverall depressive symptomsHealth-related QoLMental health QOLSubthreshold depressive symptomsSevere facial disfigurementFacial transplantationQuality of lifeImmunosuppression inductionMonths posttransplantationDepressive episodePhysical QoLHigh health statusPatientsTransplantationQoLPsychosocial functioningLife outcomesCeiling effectsFacial disfigurementSymptomsFacial restoration by transplantation
Kollar B, Pomahac B. Facial restoration by transplantation. The Surgeon 2018, 16: 245-249. PMID: 29490887, DOI: 10.1016/j.surge.2018.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultFacial InjuriesFacial TransplantationFemaleHumansMaleMiddle AgedPlastic Surgery ProceduresConceptsWorld War I.World War IIModern plastic surgerySir Harold GilliesPeter Bent Brigham HospitalWar IIFace transplantationFirst successful kidney transplantationJoseph MurraySuccessful kidney transplantationNobel PrizeWorldFacial restorationKidney transplantationTransplant cohortUnique patientsWomen's HospitalSkin graftsOrgan transplantationTransplantationHospitalPlastic surgeonsPlastic surgerySoldiersBattlefieldFace transplantation—current status and future developments
Tasigiorgos S, Kollar B, Krezdorn N, Bueno E, Tullius S, Pomahac B. Face transplantation—current status and future developments. Transplant International 2018, 31: 677-688. PMID: 29421860, DOI: 10.1111/tri.13130.Peer-Reviewed Original Research