2024
Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions
Knoedler L, Dean J, Diatta F, Thompson N, Knoedler S, Rhys R, Sherwani K, Ettl T, Mayer S, Falkner F, Kilian K, Panayi A, Iske J, Safi A, Tullius S, Haykal S, Pomahac B, Kauke-Navarro M. Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions. Frontiers In Immunology 2024, 15: 1372862. PMID: 38650942, PMCID: PMC11033354, DOI: 10.3389/fimmu.2024.1372862.Peer-Reviewed Original ResearchConceptsRegulatory myeloid cellsSolid organ transplantationVascularized composite allotransplantationMesenchymal stromal cellsT cellsTransplant patientsCellular therapyChimeric antigen receptor T cellsTransplant surgerySide effectsIncreased risk of malignancyProgression to chronic rejectionAcute rejection ratesPerioperative treatment strategiesRegulatory T cellsPromote immune toleranceRisk of malignancySystemic side effectsRelated side effectsCell typesImprove transplant survivalCAR-TCell therapy applicationsImmunosuppressive regimensChronic rejection
2023
Insights from immunoproteomic profiling of a rejected full-face transplant
Lee C, Wang D, Kauke-Navarro M, Russell-Goldman E, Xu S, Mucciarone K, Sohrabi S, Lian C, Pomahac B, Murphy G. Insights from immunoproteomic profiling of a rejected full-face transplant. American Journal Of Transplantation 2023, 23: 1058-1061. PMID: 37037378, DOI: 10.1016/j.ajt.2023.04.008.Peer-Reviewed Original ResearchConceptsVascularized Composite AllograftsT cellsChronic rejectionCD8-positive T cellsEffector T cellsFull face transplantArteriosclerotic alterationsIntragraft arteriesVCA rejectionGraft arteryAccelerated arteriosclerosisRecipient originPunch biopsyAtherogenic responseComposite allograftsImmunoproteomic profilingDioxygenase 1Target endotheliumArteryEndotheliumProteomic profilingPathway componentsCellsRejectionAllografts
2022
mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis
Eskandari SK, Allos H, Al Dulaijan B, Melhem G, Sulkaj I, Alhaddad JB, Saad AJ, Deban C, Chu P, Choi JY, Kollar B, Pomahac B, Riella LV, Berger SP, Sanders JSF, Lieberman J, Li L, Azzi JR. mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis. Frontiers In Immunology 2022, 13: 899975. PMID: 35757726, PMCID: PMC9229986, DOI: 10.3389/fimmu.2022.899975.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsHuman regulatory T cellsHost THumanized mouse modelPro-apoptotic pathwaysSkin allotransplantationClinical efficacyImmunosuppressive potencyIntracytoplasmic expressionTransplant fieldMouse modelCellular therapyHigh expressionTarget cellsRapamycin complex 1Lysosomal granulesFunctional effectsMechanistic targetPatientsApoptosisC-JunGranzymesDrug targetsS6K
2021
Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection
Win T, Crisler W, Dyring-Andersen B, Lopdrup R, Teague J, Zhan Q, Barrera V, Sui S, Tasigiorgos S, Murakami N, Chandraker A, Tullius S, Pomahac B, Riella L, Clark R. Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection. Journal Of Clinical Investigation 2021, 131 PMID: 33667197, PMCID: PMC8262560, DOI: 10.1172/jci135166.Peer-Reviewed Original ResearchConceptsVCA rejectionTransplant rejectionT cellsTissue injuryGene expression profilingAntigen-presenting cell activationT-cell receptor sequencingSolid organ transplantsCell receptor sequencingT cell activation pathwaysAntigen-specific activationProliferative T cellsCell activation pathwaysNovo Nordisk FoundationAmerican SocietyExpression profilingFace transplant patientsTransplant patientsImmunologic pathwaysImmunoregulatory networkSkin biopsiesImmunomodulatory pathwaysLimb transplantsLundbeck FoundationTransplant ResearchHuman skin is colonized by T cells that recognize CD1a independently of lipid
Cotton R, Cheng T, Wegrecki M, Le Nours J, Orgill D, Pomahac B, Talbot S, Willis R, Altman J, de Jong A, Ogg G, Van Rhijn I, Rossjohn J, Clark R, Moody D. Human skin is colonized by T cells that recognize CD1a independently of lipid. Journal Of Clinical Investigation 2021, 131: e140706. PMID: 33393500, PMCID: PMC7773353, DOI: 10.1172/jci140706.Peer-Reviewed Original ResearchConceptsT cellsSelf-lipid antigensSkin T cellsT cell autoreactivityT cell poolT cell repertoireMajor antigenic targetAntigenic targetsCell repertoireClinical diseaseCD1aSkin diseasesCD1 proteinsAntigenTCR recognitionCell poolEffector moleculesCD1a proteinLipid ligandsSmall antigensDiseaseHuman skinCellsAutoreactivityLipids
2019
Novel immunological and clinical insights in vascularized composite allotransplantation
Kollar B, Pomahac B, Riella L. Novel immunological and clinical insights in vascularized composite allotransplantation. Current Opinion In Organ Transplantation 2019, 24: 42-48. PMID: 30531538, DOI: 10.1097/mot.0000000000000592.Peer-Reviewed Original ResearchConceptsAcute rejectionT cellsComposite allotransplantationField of VCANovel immunosuppressive approachAntibody-mediated rejectionCurrent histological classificationNovel noninvasive biomarkersQuality of lifeType of rejectionIntensity of treatmentFace transplant recipientsChronic rejectionImmunosuppressive regimensVCA patientsVCA recipientsAllograft injuryCostimulation blockadeImmunosuppressive approachesImmunosuppressive therapyTransplant recipientsImmune monitoringUpper extremityHistological classificationVCA outcomes
2014
Hand transplants and the mandate for tolerance
Koulmanda M, Pomahac B, Fan Z, Murphy G, Strom T. Hand transplants and the mandate for tolerance. Current Opinion In Organ Transplantation 2014, Publish Ahead of Print: &na;. PMID: 25373855, PMCID: PMC4352932, DOI: 10.1097/mot.0000000000000138.Peer-Reviewed Original ResearchConceptsHand transplantationIL-2Hand transplantLow-dose IL-2IL-2-based therapyBalance of immunityDrug-free toleranceRegulatory T cellsUse of immunosuppressionRecent clinical trialsLife-long immunosuppressionInduction of toleranceNonhuman primate modelShort-term treatmentDrug minimizationPosttransplant periodInflammatory processClinical trialsPrimate modelT cellsPreclinical demonstrationComposite allograftsAdverse inflammationTransplantationTransplantBiomarker evaluation of face transplant rejection: association of donor T cells with target cell injury
Lian C, Bueno E, Granter S, Laga A, Saavedra A, Lin W, Susa J, Zhan Q, Chandraker A, Tullius S, Pomahac B, Murphy G. Biomarker evaluation of face transplant rejection: association of donor T cells with target cell injury. Modern Pathology 2014, 27: 788-799. PMID: 24434898, DOI: 10.1038/modpathol.2013.249.Peer-Reviewed Original ResearchConceptsTarget cell injurySkin allograft rejectionDonor T cellsRecipient T cellsT cellsCell injuryAllograft rejectionMemory T cell subsetsAssessment of rejectionFacial transplantT cell subsetsPotential translational significanceImmune cell interactionsRejection episodesClinicopathological assessmentFollicular infundibulumHistologic evidenceSerial biopsiesTransplant rejectionEpidermal targetsDonor originImmune cellsSequential biopsiesDermal microvesselsTranslational significance