2023
Insights from immunoproteomic profiling of a rejected full-face transplant
Lee C, Wang D, Kauke-Navarro M, Russell-Goldman E, Xu S, Mucciarone K, Sohrabi S, Lian C, Pomahac B, Murphy G. Insights from immunoproteomic profiling of a rejected full-face transplant. American Journal Of Transplantation 2023, 23: 1058-1061. PMID: 37037378, DOI: 10.1016/j.ajt.2023.04.008.Peer-Reviewed Original ResearchConceptsVascularized Composite AllograftsT cellsChronic rejectionCD8-positive T cellsEffector T cellsFull face transplantArteriosclerotic alterationsIntragraft arteriesVCA rejectionGraft arteryAccelerated arteriosclerosisRecipient originPunch biopsyAtherogenic responseComposite allograftsImmunoproteomic profilingDioxygenase 1Target endotheliumArteryEndotheliumProteomic profilingPathway componentsCellsRejectionAllografts
2020
Defining chronic rejection in vascularized composite allotransplantation—The American Society of Reconstructive Transplantation and International Society of Vascularized Composite Allotransplantation chronic rejection working group: 2018 American Society of Reconstructive Transplantation meeting report and white paper Research goals in defining chronic rejection in vascularized composite allotransplantation
Kaufman C, Kanitakis J, Weissenbacher A, Brandacher G, Mehra M, Amer H, Zelger B, Zelger B, Pomahac B, McDiarmid S, Cendales L, Morelon E. Defining chronic rejection in vascularized composite allotransplantation—The American Society of Reconstructive Transplantation and International Society of Vascularized Composite Allotransplantation chronic rejection working group: 2018 American Society of Reconstructive Transplantation meeting report and white paper Research goals in defining chronic rejection in vascularized composite allotransplantation. SAGE Open Medicine 2020, 8: 2050312120940421. PMID: 32704373, PMCID: PMC7361482, DOI: 10.1177/2050312120940421.Peer-Reviewed Original ResearchChronic rejectionComposite allograftsFunctional declineReconstructive transplantationComposite allotransplantationHistologic evidenceDe novo donor-specific antibodiesAmerican SocietyNovo donor-specific antibodiesNormal allograft functionDonor-specific antibodiesInternational SocietyVascularized Composite AllotransplantationAcute rejectionAllograft functionAllograft recipientsImmunosuppressive therapyTreatment regimensRisk factorsUterine transplantationUpper extremityMeeting reportAllograftsTransplantationClinical cases
2019
Five-Year Follow-up after Face Transplantation
Tasigiorgos S, Kollar B, Turk M, Perry B, Alhefzi M, Kiwanuka H, Nizzi M, Marty F, Chandraker A, Tullius S, Riella L, Pomahac B. Five-Year Follow-up after Face Transplantation. New England Journal Of Medicine 2019, 380: 2579-2581. PMID: 31141626, DOI: 10.1056/nejmc1810468.Peer-Reviewed Original ResearchFace transplantation
Sinha I, Vyas R, Pomahac B. Face transplantation. 2019, 379-382. DOI: 10.1093/med/9780199699537.003.0045.Peer-Reviewed Original ResearchReturn of sensationSevere traumatic injuryComposite tissue allotransplantationComposite tissue transplantationFacial composite tissue allotransplantationTransplanted allograftPost transplantationLifelong immunosuppressionMotor functionTraumatic injuryTissue allotransplantationPsychiatric issuesPatientsTissue transplantationInfection riskTransplantationFace transplantationFacial formImmunosuppressionAllograftsAllotransplantationInjuryPossible rejectionMonths
2018
Living Donation of Vascularized Composite Allografts
Pomahac B, Alhefzi M, Bueno E, McDiarmid S, Levin L. Living Donation of Vascularized Composite Allografts. Plastic & Reconstructive Surgery 2018, 142: 405e-411e. PMID: 29927830, DOI: 10.1097/prs.0000000000004659.Peer-Reviewed Original ResearchConceptsComposite allotransplantationComposite allograftsOrgan procurementSolid organ transplantationVascularized Composite AllograftsKidney transplant communityCurrent guidelinesOrgan transplantationTransplant communityTransplantation SocietyClinical scenariosReconstructive strategiesAesthetic outcomeTransplantation NetworkReconstructive ladderReconstructive surgeonTransplant medicineOrgan donationAllotransplantationMedicaid ServicesEthics CommitteeAllograftsDonationSpecific recommendationsExtensive type
2017
First Lower Two-Thirds Osteomyocutaneous Facial Allograft Perfused by a Unilateral Facial Artery
Fischer S, Lee T, Krezdorn N, Alhefzi M, Kueckelhaus M, Bueno E, Pomahac B. First Lower Two-Thirds Osteomyocutaneous Facial Allograft Perfused by a Unilateral Facial Artery. Plastic & Reconstructive Surgery 2017, 139: 1175e-1183e. PMID: 28445377, DOI: 10.1097/prs.0000000000003288.Peer-Reviewed Original ResearchConceptsFacial arteryFacial allograftImmunosuppressive therapyRejection episodesAirway volumeVenous outflowCLINICAL QUESTION/LEVELDual immunosuppressive therapyFacial allotransplantationTwo-thirdsMaintenance therapyMycophenolate mofetilSteroid pulseArtery anastomosisSurgical durationFacial functionTracheostomy tubeContralateral sideVascular anastomosisSubmental arteryTransplantationArteryAllograftsVascularization patternFacial form
2016
Treatment of Rejection in Vascularized Composite Allotransplantation
Alhefzi M, Aycart M, Bueno E, Kiwanuka H, Krezdorn N, Pomahac B, Tullius S. Treatment of Rejection in Vascularized Composite Allotransplantation. Current Transplantation Reports 2016, 3: 404-409. DOI: 10.1007/s40472-016-0128-3.Peer-Reviewed Original ResearchVascularized Composite AllotransplantationAcute rejectionChronic rejectionComposite allotransplantationTreatment of rejectionConventional reconstructive techniquesCommon complicationReconstructive techniquesEsthetic outcomeTherapeutic strategiesImportant modalityAllotransplantationRecent reportsTreatmentRejectionAllograftsComplicationsPreventionGuillain–Barré syndrome associated with resistant cytomegalovirus infection after face transplantation
Alhefzi M, Aycart M, Bueno E, Kueckelhaus M, Fischer S, Snook R, Sharfuddin A, Hadad I, Malla P, Amato A, Pomahac B, Marty F. Guillain–Barré syndrome associated with resistant cytomegalovirus infection after face transplantation. Transplant Infectious Disease 2016, 18: 288-292. PMID: 26910286, DOI: 10.1111/tid.12516.Peer-Reviewed Original ResearchConceptsGuillain-Barré syndromeLower extremity paresthesiasResistant cytomegalovirus infectionLower extremity weaknessSensorimotor axonal polyneuropathyExtremity weaknessIntravenous immunoglobulinAxonal polyneuropathyCMV infectionCytomegalovirus infectionExtremity paresthesiasImmune controlAxonal formTransplantationFacial allograftFace transplantationElectrophysiological evidenceMonthsSyndromeInfectionParesthesiaPolyneuropathyAllograftsRecurrenceCMV
2015
Transformation of Face Transplants: Volumetric and Morphologic Graft Changes Resemble Aging After Facial Allotransplantation
Kueckelhaus M, Turk M, Kumamaru K, Wo L, Bueno E, Lian C, Alhefzi M, Aycart M, Fischer S, De Girolami U, Murphy G, Rybicki F, Pomahac B. Transformation of Face Transplants: Volumetric and Morphologic Graft Changes Resemble Aging After Facial Allotransplantation. American Journal Of Transplantation 2015, 16: 968-978. PMID: 26639618, DOI: 10.1111/ajt.13544.Peer-Reviewed Original ResearchConceptsLong-term outcomesFacial allograftFacial allotransplantationSuperior long-term outcomesShort-term resultsRisk-benefit assessmentSoft tissue volumeSignificant volume lossTransplant recipientsVolume lossDiagnostic evaluationDonor selectionMuscle biopsyHistological evaluationComputed tomographyBone atrophyAllograftsFuture clinical routineNormal anatomyRecipient tissuesAllotransplantationClinical routineMorphometric changesSoft tissueMuscle fibers
2012
Facial Composite Tissue Allograft
Pomahac B, Pribaz J. Facial Composite Tissue Allograft. Journal Of Craniofacial Surgery 2012, 23: 265-267. PMID: 22337422, DOI: 10.1097/scs.0b013e318241b8b8.Peer-Reviewed Original ResearchConceptsSuperficial temporal vesselsTemporal vesselsPeripheral facial nerve branchesComposite tissue allograftsFacial nerve branchesExternal auditory canalHair-bearing scalpComplete sensoryOcular ischemiaOropharyngeal dysfunctionNerve branchesAuditory canalFacial nerveDifficult dissectionTissue allograftsNerve connectionsPreauricular areaCarotid anastomosisMuscle insertionFacial vesselsFacial allograftFunctional problemsSoft tissueDissectionAllografts
2011
Three Patients with Full Facial Transplantation
Pomahac B, Pribaz J, Eriksson E, Bueno E, Diaz-Siso J, Rybicki F, Annino D, Orgill D, Caterson E, Caterson S, Carty M, Chun Y, Sampson C, Janis J, Alam D, Saavedra A, Molnar J, Edrich T, Marty F, Tullius S. Three Patients with Full Facial Transplantation. New England Journal Of Medicine 2011, 366: 715-722. PMID: 22204672, DOI: 10.1056/nejmoa1111432.Peer-Reviewed Original ResearchConceptsFull face transplantFull facial transplantationFacial transplantationAcute rejectionPostoperative complicationsSensory nervesSevere deformityFunctional restorationPatientsSingle episodeFacial allograftTransplantationFacial appearanceConventional reconstructionComplicationsAllograftsNerveGlucocorticoidsTransplantDeformityCoaptationMonths
2009
The Skin Allograft Revisited: A Potentially Permanent Wound Coverage Option in the Critically Ill Patient
Pomahac B, Garcia J, Lazar A, Tilney N, Orgill D. The Skin Allograft Revisited: A Potentially Permanent Wound Coverage Option in the Critically Ill Patient. Plastic & Reconstructive Surgery 2009, 123: 1755-1758. PMID: 19483575, DOI: 10.1097/prs.0b013e3181a65b1b.Peer-Reviewed Original Research