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Clinical Study Investigates Impact of Phosphate Metabolism on Healthy Aging

January 10, 2022
by Jane E. Dee

Phosphate is an important component of bones and keeps them strong. Genetic disorders of phosphate metabolism, have long been a research focus of Yale School of Medicine’s pediatric and adult endocrinologists. Clemens Bergwitz, MD, of the Yale Bone Center, and collaborators in the Bergwitz lab, are currently recruiting patients with X-linked hypophosphatemia (XLH) and hereditary hypophosphatemic rickets with hypercalciuria (HHRH).

The clinical study will help researchers determine whether current standard-of-care with phosphate supplementation is safe, or whether this therapy has long-term consequences for cardiovascular, vascular and renal health. Individuals who agree to participate will spend two half-days at the Yale Center for Clinical Investigation in New Haven for blood, urine, and non-invasive vascular and sonographic studies to determine the acute and long-term response to phosphate supplementation. For more information, please see the study description, or email the principle investigator, Clemens Bergwitz, MD.


Yale’s Section of Endocrinology & Metabolism works to improve the health of individuals with endocrine and metabolic diseases by advancing scientific knowledge; applying new information to patient care; and training the next generation of physicians and scientists to become leaders in the field. To learn more about their work, visit Endocrinology & Metabolism.