Thilinie D Bandaranayake, MBBS, FIDSA
Cards
About
Research
Publications
2024
Experience with expanded use of oritavancin in a tertiary hospital: indications, tolerability and outcomes
Bandaranayake T, Radcliffe C, Cvercko M, Golden M, Hao R. Experience with expanded use of oritavancin in a tertiary hospital: indications, tolerability and outcomes. JAC-Antimicrobial Resistance 2024, 6: dlae174. PMID: 39493938, PMCID: PMC11524893, DOI: 10.1093/jacamr/dlae174.Peer-Reviewed Original ResearchDose of oritavancinInfective endocarditisTreatment of acute bacterial skinBacterial infectionsLipoglycopeptide antibacterial agentTertiary care medical centreAcute bacterial skinGram-positive bacterial infectionsInvasive bacterial infectionsTreatment failure rateNinety-five adult patientsSoft tissue infectionsProsthetic joint infectionGram-positive organismsBacterial skinDrug discontinuationTissue infectionsRetrospective studyAdult patientsClinical outcomesAdverse eventsOritavancinOff-labelJoint infectionTreat infectionsSevere Clinical Outcomes Due to Human Adenoviral Respiratory Infections in Hospitalized Immunocompetent Adults
Legakis L, Nguyen D, Bandaranayake T. Severe Clinical Outcomes Due to Human Adenoviral Respiratory Infections in Hospitalized Immunocompetent Adults. Infectious Diseases In Clinical Practice 2024, 32: e1412. DOI: 10.1097/ipc.0000000000001412.Peer-Reviewed Original ResearchSevere adenoviral infectionAdenoviral infectionImmunocompetent patientsClinical outcomesSmoking historyPulmonary diseaseRisk factorsSevere diseaseAdenoviral respiratory infectionUpper respiratory tract infectionRespiratory viral panelAbsence of feverAdult immunocompetent patientsExtracorporeal membrane oxygenationRespiratory tract infectionsSevere clinical outcomesChronic obstructive pulmonary diseasePresence of coinfectionObstructive pulmonary diseasePotential risk factorsCritical careImmunocompetent adultsImmunocompromised patientsImmunocompetent hostsTract infections
2022
Mucocutaneous Leishmaniasis in a Pregnant Immigrant
Briggs N, Wei BM, Ahuja C, Baker C, Palacios C, Lee E, O’Grady N, Singanamala S, Singh K, Bandaranayake TD, Cohen JM, Damsky W, Davis MW, Mejia R, Nelson CA, Topal JE, Azar MM. Mucocutaneous Leishmaniasis in a Pregnant Immigrant. Open Forum Infectious Diseases 2022, 9: ofac360. PMID: 35928503, PMCID: PMC9345408, DOI: 10.1093/ofid/ofac360.Peer-Reviewed Original ResearchHazzard's Geriatric Medicine and Gerontology, 8e: Immunology and Inflammation.
Shaw AC, Bandaranayake TD. Immunology and Inflammation. In: Halter JB, Ouslander JG, Studenski S, High KP, Asthana S, Supiano MA, Ritchie CS, Schmader K. eds. Hazzard's Geriatric Medicine and Gerontology, 8e. McGraw-Hill Education; 2022. Accessed February 05, 2024. https://accessmedicine.mhmedical.com/content.aspx?bookid=3201§ionid=266644604Chapters
2020
Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults
Avey S, Mohanty S, Chawla DG, Meng H, Bandaranayake T, Ueda I, Zapata HJ, Park K, Blevins TP, Tsang S, Belshe RB, Kaech SM, Shaw AC, Kleinstein SH. Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults. The Journal Of Immunology 2020, 204: 1661-1673. PMID: 32060136, PMCID: PMC7755271, DOI: 10.4049/jimmunol.1900922.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAgingAntibodies, ViralCohort StudiesFemaleGene Expression ProfilingHemagglutination Inhibition TestsHumansImmunogenicity, VaccineInfluenza A virusInfluenza VaccinesInfluenza, HumanMaleNK Cell Lectin-Like Receptor Subfamily BOligonucleotide Array Sequence AnalysisSeasonsTranscriptomeVaccinationVaccines, InactivatedYoung AdultConceptsVaccine-induced Ab responsesOlder adultsInfluenza vaccinationDays postvaccinationInfluenza vaccineAb responsesMore effective influenza vaccinesImportant public health toolInactivated influenza vaccinationSeasonal influenza vaccineVaccine-induced immunityEffective influenza vaccinesMolecular signaturesEffects of immunosenescencePublic health toolImmune signaturesVaccination seasonVaccine responsesVaccine compositionSubset of individualsAge groupsHealth toolsSingle age groupAdultsPostvaccination
2018
Fatal cryptococcal meningitis in an AIDS patient complicated with immune reconstitution syndrome refractory to prolonged amphotericin B treatment
Bandaranayake TD, Ogbuagu OE, Mahajan A, Vortmeyer AO, Villanueva MS. Fatal cryptococcal meningitis in an AIDS patient complicated with immune reconstitution syndrome refractory to prolonged amphotericin B treatment. International Journal Of STD & AIDS 2018, 29: 1250-1254. PMID: 29749873, DOI: 10.1177/0956462418773219.Peer-Reviewed Case Reports and Technical NotesConceptsCentral nervous system diseaseNervous system diseasesCryptococcal meningitisSystem diseasesSevere central nervous system diseaseFatal cryptococcal meningitisLiposomal amphotericin BAmphotericin B treatmentImmune recoveryPatient refractoryAntiretroviral therapyTherapeutic challengeTreatment failureAIDS patientsCystic lesionsFatal casesTreatment approachesMeningitisAmphotericin BC. neoformansMultiple coursesCryptococcus neoformansPatientsB treatmentDisease
2016
Host Resistance and Immune Aging
Bandaranayake T, Shaw AC. Host Resistance and Immune Aging. Clinics In Geriatric Medicine 2016, 32: 415-432. PMID: 27394014, PMCID: PMC6986475, DOI: 10.1016/j.cger.2016.02.007.Peer-Reviewed Original ResearchConceptsImmune systemImpaired innate immune responseToll-like receptor functionEarly pro-inflammatory responseNeutrophil extracellular trap formationT cell compartmentB cell subsetsPro-inflammatory responseExtracellular trap formationInnate immune responseInnate immune systemAdaptive immune systemHuman immune systemBasal inflammationCytomegalovirus infectionImmune agingCell subsetsImmunologic challengeImmune responseT-lineageReceptor functionOlder adultsFunction altersCell compartmentAgeImmunology and Aging.
1. A.C. Shaw and T.D. Bandaranayake. Immunology and Aging. In: Halter, J., Ouslander, J., Studenski, S., High, K., Asthana, S., Ritchie, C., Supiano, M. eds. Hazzard's Geriatric Medicine and Gerontology, Seventh Edition. McGraw-Hill, 2016.Books
2015
Prototheca wickerhamii algaemia: an emerging infection in solid organ transplant recipients
Bandaranayake TD, Mondolfi A, Peaper DR, Malinis MF. Prototheca wickerhamii algaemia: an emerging infection in solid organ transplant recipients. Transplant Infectious Disease 2015, 17: 599-604. PMID: 26040253, DOI: 10.1111/tid.12407.Peer-Reviewed Case Reports and Technical NotesConceptsSolid organ transplant recipientsOrgan transplant recipientsTransplant recipientsRenal transplant recipientsDisseminated diseaseCutaneous lesionsFatal casesEarly diagnosisRecipientsPrevious casesImpact outcomesPrototheca wickerhamiiDiseaseHuman diseasesP. wickerhamiiLesionsVoriconazoleInfectionDiagnosisFlight mass spectrometryMatrix-assisted laser desorption ionization time
Academic Achievements & Community Involvement
Teaching & Mentoring
Teaching
Didactic MD 1075: Attacks and Defenses
Supervising FacultyLecture Setting11/1/2021 - PresentForGraduate8 Average Instructional Hours Per YearAttacks and Defenses introduces principles of immunity, tissue injury and repair and medical microbiology. These principles are integrated with the clinical fields of clinical immunology and allergy, infectious diseases, dermatology and rheumatology. Students are introduced to the prevention, diagnosis, and management of infectious, allergic, autoimmune and immune deficiency related diseases. Selected examples of immune based neoplastic therapy especially with respect to melanoma. Medical microbiology and infectious disease are taught during the entire course. Principles of immunobiology are taught concurrently with clinical immunology, followed by rheumatology and then dermatology. Understanding disease in underserved and diverse populations is a critical component of the course.
Clinical Care
Overview
Thilinie Bandaranayake, MBBS, is a infectious disease specialist who treats a variety of conditions, including infections in the bloodstream, soft tissue, and joints, as well as hospital-acquired conditions including pneumonia.
“I am fascinated by how these tiny micro-organisms that you can’t even see can cause devastating illness and outcomes,” says Dr. Bandaranayake. There are times when she is learning something new almost every day, often consulting with other types of specialists since infectious diseases can affect multiple organs. “Sometimes you don’t know what you’re treating and you go into the patient’s history and you find things—like an experience they had while traveling—that help you diagnose,” she says. “The problem could be bacterial, fungal, viral, parasitic—it could be anything. If you identify a condition and treat it properly, it can make a world of difference.”
Some infectious diseases are challenging, but the majority are treatable, Dr. Bandaranayake says. “Sometimes you see a patient in the intensive care unit and they are really sick, maybe intubated. Then you see them again in the outpatient clinic, walking, talking, looking totally different. Seeing a patient lead a normal life after a serious infection is very rewarding,” she says.
Dr. Bandaranayake is also a researcher with an interest in the immune system and how age affects immune responses to such diseases as measles, adenovirus, and cytomegalovirus (a common virus that a healthy immune system can usually fight off). She is also involved in clinical trials to develop better treatments for HIV.
Clinical Specialties
Fact Sheets
MRSA and Drug-Resistant Microbes
Learn More on Yale MedicinePediatric Sepsis
Learn More on Yale MedicineAvoiding Infectious Diseases
Learn More on Yale MedicinePreventing Infections in the NICU
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Board Certifications
Infectious Disease
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2018
- Original Certification Date
- 2015
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2018
- Original Certification Date
- 2013
Yale Medicine News
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- September 16, 2019
2019 Department of Internal Medicine Faculty Appointments and Promotions
- November 08, 2015
Yale Medical Group welcomes its newest physicians