Slide 8

Changes in neuronal excitability or activity with memory or attention paradigms occurs rapidly - within 100 msec or so. Similarily, the activity of layer 5 neurons also exhibits rapid changes in activity in the transition from the DOWN to UP state and visa versa. Note also the relatively steady level of activity maintained in the extracellular (A) and intracellular (B). C. Overlap of several UP states illustrating that the general shape of the synaptic activity is highly repeatable between trials.