Christopher Regan, MD, FACC, FSCAI, RPVI
Associate Professor of Medicine (Cardiovascular Medicine)Cards
About
Research
Publications
2024
Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach.
Regan C, Scierka L, Dardik A, Tonnessen B, Iyad Ochoa Chaar C, Ionescu C, Aboian E, Cardella J, Nassiri N, Guzman R, Attaran R, Nagpal S, Shah S, Smolderen K, Mena-Hurtado C. Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach. Vascular 2024, 17085381241246318. PMID: 38669051, DOI: 10.1177/17085381241246318.Peer-Reviewed Original ResearchDual antiplatelet therapyPeripheral arterial diseaseCYP2C19 testingCYP2C19 mutationsHeterogeneity of treatment effectsPeripheral vascular interventionsConsensus statementKnowledge questionsAntiplatelet therapyGenetic testingVascular surgeryAcademic health systemBarriers to implementationInterquartile rangeCYP2C19 genotype testingVascular diseaseInterventional cardiologyModified Delphi methodPatient's metabolic statusManagement of patientsCritical limb ischemiaPerceived barriersPeripheral vascular diseaseArterial vascular diseaseClinician perspectives
2023
Trends and impact of intravascular ultrasound and optical coherence tomography on percutaneous coronary intervention for myocardial infarction
Park D, Vemmou E, An S, Nikolakopoulos I, Regan C, Cambi B, Frampton J, Vij A, Brilakis E, Nanna M. Trends and impact of intravascular ultrasound and optical coherence tomography on percutaneous coronary intervention for myocardial infarction. IJC Heart & Vasculature 2023, 45: 101186. PMID: 36852085, PMCID: PMC9957744, DOI: 10.1016/j.ijcha.2023.101186.Peer-Reviewed Original ResearchIntravascular imaging-guided percutaneous coronary interventionImaging-guided percutaneous coronary interventionPercutaneous coronary interventionOptical coherence tomographyMyocardial infarctionIntravascular ultrasoundCoronary interventionIntravascular imagingIVUS-guided percutaneous coronary interventionCoherence tomographyNumber of PCIsNational Inpatient SampleMultivariable logistic regressionCochran-Armitage trend testIVUS useHospital mortalityClinical outcomesOCT guidanceInpatient SampleImproved outcomesLower oddsLower mortalityLogistic regressionContinuous outcomesOutcomes
2021
Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study
Jelani QU, Mena-Hurtado C, Gosch K, Mohammed M, Labrosciano C, Regan C, Scierka LE, Spertus JA, Nagpal S, Smolderen KG. Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study. PLOS ONE 2021, 16: e0256933. PMID: 34506511, PMCID: PMC8432750, DOI: 10.1371/journal.pone.0256933.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePeripheral Artery QuestionnaireSleep apneaHealth statusArtery diseaseSummary scoresDisease-specific Peripheral Artery QuestionnaireFive-year survival curvesHigh ankle-brachial indexPAQ summary scoreVascular specialty clinicsAnkle-brachial indexLog-rank testSleep apnea statusHealth status outcomesWorse health statusQuality of lifeBetter health statusCause mortalityMultivariable adjustmentPAD symptomsCoronary diseasePeripheral interventionsUS patientsMean ageSafety and efficacy outcomes of the Pioneer Plus catheter in endovascular revascularization of lower extremity chronic total occlusions
Sheikh AB, Llanos-Chea F, Jelani QU, Anantha-Narayanan M, Attaran R, Schneider M, Ionescu C, Regan C, Nagpal S, Smolderen KG, Mena-Hurtado C. Safety and efficacy outcomes of the Pioneer Plus catheter in endovascular revascularization of lower extremity chronic total occlusions. Journal Of Vascular Surgery 2021, 74: 746-755. PMID: 33592298, DOI: 10.1016/j.jvs.2021.01.045.Peer-Reviewed Original ResearchConceptsMajor adverse limb eventsAdverse limb eventsDevice-related complicationsProcedure-related complicationsProcedure-related outcomesProcedural successEfficacy outcomesPseudoaneurysm formationSafety outcomesLimb eventsLower extremity chronic total occlusionMajor adverse cardiovascular eventsChronic total occlusion interventionAccess site hematomaAcute arterial thrombosisAcute limb ischemiaAdverse cardiovascular eventsProvider-level factorsArteriovenous fistula formationHigh-volume centersChronic total occlusionMajor bleedingPreprocedural symptomsCardiovascular eventsCatheter use
2020
Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease
Anantha-Narayanan M, Sheikh AB, Nagpal S, Jelani QU, Smolderen KG, Regan C, Ionescu C, Ochoa Chaar CI, Schneider M, Llanos-Chea F, Mena-Hurtado C. Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease. Journal Of Vascular Surgery 2020, 73: 331-340.e4. PMID: 32889074, DOI: 10.1016/j.jvs.2020.08.032.Peer-Reviewed Original ResearchConceptsCKD/end-stage renal diseaseEnd-stage renal diseaseNormal renal functionChronic kidney diseaseTarget lesion revascularizationLong-term mortalityPeripheral arterial diseaseRenal functionPAD interventionsMajor amputationRenal diseaseKidney diseaseOdds ratioNormal renal function groupIntervention typeRenal function groupCritical limb ischemiaPeripheral arterial interventionsConfidence intervalsPooled odds ratioOpen surgical approachMultivariable regression analysisCase-control matchingRandom-effects modelEvidence-based strategiesSafety and efficacy of paclitaxel drug-coated balloon in femoropopliteal in-stent restenosis
Anantha-Narayanan M, Love K, Nagpal S, Sheikh AB, Regan CJ, Mena-Hurtado C. Safety and efficacy of paclitaxel drug-coated balloon in femoropopliteal in-stent restenosis. Expert Review Of Medical Devices 2020, 17: 533-539. PMID: 32525406, DOI: 10.1080/17434440.2020.1770593.Peer-Reviewed Original ResearchConceptsDrug-coated balloonsPlain old balloon angioplastyPeripheral arterial diseaseFP-ISRFP diseaseStent restenosisEfficacy of DCBUse of DCBPaclitaxel drug-coated balloonFirst-line therapyRecurrence of symptomsSelf-expanding nitinol stentsHigher patency rateLong-term safetyLesion revascularizationEndovascular therapyISR rateRandomized studyArterial diseaseBalloon angioplastyFemoropopliteal segmentPatency ratesCommon siteTerm safetyNitinol stentsUtility of Intravascular Ultrasound in Peripheral Vascular Interventions: Systematic Review and Meta-Analysis
Sheikh AB, Anantha-Narayanan M, Smolderen KG, Jelani QU, Nagpal S, Schneider M, Llanos F, Ionescu C, Regan C, Attaran R, Altin SE, Mena-Hurtado C. Utility of Intravascular Ultrasound in Peripheral Vascular Interventions: Systematic Review and Meta-Analysis. Vascular And Endovascular Surgery 2020, 54: 413-422. PMID: 32338163, DOI: 10.1177/1538574420920998.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsPeriprocedural adverse eventsVascular complicationsAdverse eventsIntravascular ultrasoundPrimary patencyCause mortalityTechnical successMyocardial infarctionObservational studyVascular interventionsEnd pointSimilar patency ratesSimilar primary patencyPrimary end pointRate of reinterventionSecondary end pointsPeripheral arterial diseaseImproved clinical outcomesIVUS groupAmputation rateArterial diseaseClinical outcomesPatency ratesLower risk
2019
Drug‐coated balloon versus plain old balloon angioplasty in femoropopliteal disease: An updated meta‐analysis of randomized controlled trials
Anantha‐Narayanan M, Shah SM, Jelani Q, Garcia S, Ionescu C, Regan C, Mena‐Hurtado C. Drug‐coated balloon versus plain old balloon angioplasty in femoropopliteal disease: An updated meta‐analysis of randomized controlled trials. Catheterization And Cardiovascular Interventions 2019, 94: 139-148. PMID: 30838719, DOI: 10.1002/ccd.28176.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmputation, SurgicalAngioplasty, BalloonCardiovascular AgentsCoated Materials, BiocompatibleEquipment DesignFemaleFemoral ArteryHumansLimb SalvageMalePeripheral Arterial DiseasePopliteal ArteryRandomized Controlled Trials as TopicRisk FactorsTreatment OutcomeVascular Access DevicesVascular PatencyConceptsTarget vessel revascularizationPeripheral arterial diseaseFemoropopliteal diseaseBalloon angioplastyRate of TVRDrug-coated balloon angioplastyPlain old balloon angioplastyAvailable RCT dataDevice-related mortalityImproved vessel patencyPrimary safety endpointMainstay of therapyCochrane's Q statisticLate lumen lossDrug-coated balloonsRandom-effects modelQ statisticMajor amputationSafety endpointVessel revascularizationDCB groupPopliteal arteryArterial diseaseUse of DCBLumen lossPATTERNS AND PREDICTORS OF REFERRAL FOR INVASIVE MANAGEMENT OF PERIPHERAL ARTERIAL DISEASE IN THE UNITED STATES: INSIGHTS FROM THE PORTRAIT REGISTRY
Jelani Q, Shah S, Yuanyuan T, Spertus J, Smolderen K, Aronow H, Paredes M, Attaran R, Regan C, Mena-Hurtado C. PATTERNS AND PREDICTORS OF REFERRAL FOR INVASIVE MANAGEMENT OF PERIPHERAL ARTERIAL DISEASE IN THE UNITED STATES: INSIGHTS FROM THE PORTRAIT REGISTRY. Journal Of The American College Of Cardiology 2019, 73: 2044. DOI: 10.1016/s0735-1097(19)32650-6.Peer-Reviewed Original ResearchReview of the Current Basic Science Strategies to Treat Critical Limb Ischemia
Haghighat L, Ionescu CN, Regan CJ, Altin SE, Attaran RR, Mena-Hurtado CI. Review of the Current Basic Science Strategies to Treat Critical Limb Ischemia. Vascular And Endovascular Surgery 2019, 53: 316-324. PMID: 30808262, DOI: 10.1177/1538574419831489.Peer-Reviewed Original ResearchConceptsCritical limb ischemiaLimb ischemiaDevelopment of CLIMolecular therapyPoor surgical candidatesImpairment of angiogenesisSurgical candidatesMicrovascular changesNovel imaging modalityTreatment optionsMorbid diseaseTranslational medicine studiesTherapyMedicine studiesImaging modalitiesIschemiaDiseasePatientsPathophysiologyArteriogenesisImpairmentTrials
Academic Achievements & Community Involvement
Clinical Care
Overview
Christopher Regan, MD, is an interventional cardiologist, a specialist who uses minimally invasive catheter-based procedures to treat coronary artery disease and peripheral vascular disease—the narrowing or blocking of the arteries usually caused by cholesterol and fatty deposits.
Dr. Regan says he chose his field when he was in training and seeing patients with severe chest pain. “There was an interventional cardiologist who would do his work, and within an hour the patient would be thanking him and shaking his hand,” he says.
Almost 20 years later, some cases still require open heart surgery, but catheterization is providing an easier alternative in more situations. “No incision is needed for these procedures. We go through the skin and just use needles and tubes to fix the problem,” Dr. Regan says. He inserts a flexible tube, or catheter, through the skin and into the artery to guide in a small balloon to push the artery open. Then, he places a tube called a stent to keep it open.
Catheterization itself is changing, says Dr. Regan, who is also a researcher investigating ways to improve the devices he uses. While the procedure traditionally involves inserting a catheter in through the femoral artery in the groin area, smaller, specially designed tubes are making it possible to start more procedures in the radial artery from the wrist area. “That’s a fantastic advance because the patient doesn’t have to lay flat for a four- to six-hour period to allow the artery in the leg to heal,” he says. “The risk of bleeding and damage to the artery is reduced because the artery is so small that you would see even a small amount of blood right away, and you can just put some pressure on it.”
He especially enjoys his work when he walks a patient through a procedure and watches as the patient starts to understand it. “It brings a lot of comfort to them, and I can see that,” he says. “They may still be nervous, but I can see the change in them in the office visit. Also, these are procedures that only require moderate sedation, so patients are awake enough that I can tell them what's going on during the procedure. Then, I go over everything with them afterwards. And that's very gratifying.”
Clinical Specialties
Fact Sheets
Bundle Branch Block
Learn More on Yale MedicineCoronary Atherosclerosis Treatments
Learn More on Yale MedicineCoronary Artery Disease (CAD)
Learn More on Yale MedicineImplantable Cardioverter Defibrillator
Learn More on Yale Medicine
Board Certifications
Interventional Cardiology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2015
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2014