Yuan Lu, ScD
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Cardiovascular Medicine
Primary
Chronic Disease Epidemiology
Secondary
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Biography
Dr. Lu was trained in epidemiology and global health, with a particular focus on cardiovascular diseases. She obtained both of her ScD and MSc Degrees in Global Health and Population at the Harvard School of Public Health. She works in the intersection of cardiovascular disease prevention, clinical informatics, and digital health, using implementation science methods to resolve real-world issues. Her long-term goal is to improve care and outcomes of cardiovascular diseases by designing and implementing technology-based interventions.
She successfully completed an NHLBI K12 career development award in implementation science. During this award, she harnessed electronic health records from the Yale New Haven Health System to identify patients with persistent hypertension and designing decision support systems to improve their care. Currently, Dr. Lu serves as the Principal Investigator for an NIH R01 grant, where she leverages real-world data from five electronic health record databases encompassing over 100 million US adults. The goal of this endeavor is to generate real-world evidence that informs decisions regarding hypertension treatment escalation.
In addition to her domestic contributions, Dr. Lu has engaged in groundbreaking collaborative projects between Yale University and the Chinese National Center for Cardiovascular Diseases in Beijing. These include the Millions Persons Project that assembles remarkable population health and biomedical resources from 5 million individuals across China. Moreover, she has collaborated with the NCD Risk Factor Collaboration (NCD-RisC) on global analyses examining the impact of risk factors on the worldwide burden of cardiovascular diseases.
She has authored over 200 peer-reviewed publications, including first and senior author articles in leading journals such as The Lancet, JAMA, BMJ, Circulation, and JACC, and her work has been cited more than 50,000 times. Dr. Lu is the recipient of the 2022 John H. Laragh Research Award of the American Journal of Hypertension for her contribution to the field of hypertension. She is a Fellow of the American Heart Association and the American College of Cardiology, and currently serves as an Executive Associate Editor at JACC.
Last Updated on May 15, 2026.
Appointments
Cardiovascular Medicine
Associate Professor on TermPrimaryBiomedical Informatics & Data Science
Associate Professor on TermSecondaryChronic Disease Epidemiology
Assistant ProfessorSecondary
Other Departments & Organizations
- Biomedical Informatics & Data Science
- Cardiovascular Medicine
- Center for Outcomes Research & Evaluation (CORE)
- Chronic Disease Epidemiology
- Internal Medicine
- Janeway Society
- Preventive Cardiovascular Health Program at Yale
- Yale Obesity Research Center (Y-Weight)
- Yale UNRAVEL Study
Education & Training
- ScD
- Harvard School of Public Health, Global Health and Population (2015)
Research
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Overview
Medical Research Interests
Cardiovascular Diseases; Chronic Disease
Public Health Interests
Epidemiology Methods; Global Health; Implementation Science; Obesity
ORCID
0000-0001-5264-2169- View Lab Website
Yale/YNHH Center for Outcomes Research and Evaluation (CORE)
Research at a Glance
Yale Co-Authors
Frequent collaborators of Yuan Lu's published research.
Publications Timeline
A big-picture view of Yuan Lu's research output by year.
Research Interests
Research topics Yuan Lu is interested in exploring.
Harlan Krumholz, MD, SM
Erica Spatz, MD, MHS
Mitsuaki Sawano, MD, PhD
César Caraballo Cordovez, MD
Rohan Khera, MD, MS
Shiwani Mahajan, MBBS, MHS
158Publications
42,846Citations
Cardiovascular Diseases
Chronic Disease
Publications
2026
Geographic variation in eligibility and uptake of GLP-1 receptor agonists for obesity in US adults
Jian X, Kang B, Zhang B, Tang H, Xu H, Chen Y, Lu Y. Geographic variation in eligibility and uptake of GLP-1 receptor agonists for obesity in US adults. American Journal Of Preventive Cardiology 2026, 29: 101653. DOI: 10.1016/j.ajpc.2026.101653.Peer-Reviewed Original ResearchAltmetricAssociation of Reproductive Factors with Acute Myocardial Infarction in Young Women: A VIRGO and NHANES case-control study
Dong W, Yang H, Sawano M, Li S, Xu X, Murugiah K, Krumholz H, Lu Y. Association of Reproductive Factors with Acute Myocardial Infarction in Young Women: A VIRGO and NHANES case-control study. American Journal Of Preventive Cardiology 2026, 101700. DOI: 10.1016/j.ajpc.2026.101700.Peer-Reviewed Original ResearchAltmetricConceptsAcute myocardial infarction subtypeAssociations of reproductive factorsReproductive factorsAcute myocardial infarctionCase-control studyTraditional risk factorsMenopausal statusYoung womenAssociated with lower oddsAssociated with higher oddsBirth control pillsFemale hormone useConditional logistic regressionRisk factorsMyocardial infarctionControl pillsLower oddsHigher oddsEarly menarcheStratified analysisHormone useOdds ratioPrevention strategiesSocioeconomic variablesOlder womenCardiovascular Health Promotion and Disease Prevention in China Calling for New-Era Strategies
Li X, Lv J, Pan A, Lu Y, Cai J, Li J, Lu J, Lu X, Wang Z, Zhang H, Tian Y, Lin C, Wu Y, Chen Z, Hu S. Cardiovascular Health Promotion and Disease Prevention in China Calling for New-Era Strategies. JACC Asia 2026 PMID: 42246896, DOI: 10.1016/j.jacasi.2026.03.033.Peer-Reviewed Original ResearchConceptsHealth Promotion and Disease PreventionPrimary health care systemPrimary care providersSecondary prevention medicationsHealth care systemPrevention of cardiovascular diseasePublic health servicesCardiovascular diseaseHealthy China InitiativeSupportive social environmentLifestyle adherenceHealth promotionCare providersHealthy behaviorsHealth servicesHealthy lifestyleCare coverageCare systemPreventive medicationsSecular trendsDisease preventionVulnerable populationsVulnerable groupsSurveillance systemLifestylePhenome-wide analysis of downstream health outcomes following second-line antidiabetic agent prescriptions in All of Us
Salvatore M, Zhang B, Tang H, Lu Y, Zhang D, Zhou T, Lu Y, Amaro A, D. Ritchie M, Chen Y. Phenome-wide analysis of downstream health outcomes following second-line antidiabetic agent prescriptions in All of Us. Nature Communications 2026 PMID: 42185271, DOI: 10.1038/s41467-026-72947-y.Peer-Reviewed Original ResearchAltmetricConceptsSodium-glucose cotransporter-2 inhibitorsDipeptidyl peptidase-4 inhibitorsType 2 diabetesGLP-1 RA prescriptionGLP-1Glucagon-like peptide-1 receptor agonistsPeptide-1 receptor agonistsPhenome-wide analysisCotransporter-2 inhibitorsGLP-1 RAsPeptidase-4 inhibitorsMean survival time analysisCox proportional hazards modelsIntention-to-treatProportional hazards modelRetrospective cohort designPhenome-wideGenitourinary infectionsReceptor agonistsSodium-glucoseMetabolic outcomesElectronic health record dataWeight managementPhenome-wide association studyHazards modelRising Hypertension Mortality Rates Are Independent of Coding Drift
Arun A, Yang H, Lu Y, Krumholz H. Rising Hypertension Mortality Rates Are Independent of Coding Drift. Hypertension 2026, 83: e26694. PMID: 42160499, PMCID: PMC13192289, DOI: 10.1161/hypertensionaha.126.26694.Peer-Reviewed Original ResearchAltmetricPatterns and Trends of Glucose‐Lowering Therapy in Alzheimer's Disease and Related Dementias
Tang H, Zhang B, Lu Y, Lu Y, Amaro A, Lu Y, Wolk D, Chen Y. Patterns and Trends of Glucose‐Lowering Therapy in Alzheimer's Disease and Related Dementias. Diabetes Obesity And Metabolism 2026 PMID: 42119996, DOI: 10.1111/dom.70817.Peer-Reviewed Original ResearchAltmetricSingle-Pill Combination Therapy for Hypertension Persistent Underuse in the United States, 2015-2025
Choi K, Kim C, Spatz E, Krumholz H, Lu Y. Single-Pill Combination Therapy for Hypertension Persistent Underuse in the United States, 2015-2025. Journal Of The American College Of Cardiology 2026 PMID: 42089854, DOI: 10.1016/j.jacc.2026.03.088.Peer-Reviewed Original ResearchAltmetricBlood Pressure Measurement at a Turning Point From Technique to Transformation
Lu Y. Blood Pressure Measurement at a Turning Point From Technique to Transformation. Journal Of The American College Of Cardiology 2026, 87: 2543-2545. PMID: 42126154, DOI: 10.1016/j.jacc.2026.02.5098.Peer-Reviewed Original ResearchRisk Without Recognition Anticipating the Rise of SMuRF-Less Myocardial Infarction
Lu Y, Yang H. Risk Without Recognition Anticipating the Rise of SMuRF-Less Myocardial Infarction. JACC Asia 2026, 6: 926-928. PMID: 41999372, PMCID: PMC13244095, DOI: 10.1016/j.jacasi.2026.02.022.Commentaries, Editorials and LettersCardiometabolic Profiles of Oral and Subcutaneous Glucagon‐Like Peptide‐1 Receptor Mono‐Agonists in Adults With Overweight or Obesity: A Systematic Review and Network Meta‐Analysis
Lu Y, Chen J, Guo Y, Ding H, Liu Y, Van Name M, Sharifi M, Lu Y, Chen Y. Cardiometabolic Profiles of Oral and Subcutaneous Glucagon‐Like Peptide‐1 Receptor Mono‐Agonists in Adults With Overweight or Obesity: A Systematic Review and Network Meta‐Analysis. Diabetes Obesity And Metabolism 2026, 28: 5761-5766. PMID: 41992023, PMCID: PMC13243969, DOI: 10.1111/dom.70742.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdministration, OralAdultDiabetes Mellitus, Type 2Fluorine CompoundsGlucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsGlycated HemoglobinHumansHypoglycemic AgentsInjections, SubcutaneousLiraglutideObesityOverweightOxadiazolesRandomized Controlled Trials as TopicWeight LossConceptsNetwork Meta-AnalysisRandomized Controlled TrialsGlucagon-like peptide-1Cardiometabolic profileMono-agonistsNon-T2DMeta-analysisSystolic blood pressureType 2 diabetesOral semaglutideCardiometabolic improvementsWaist circumferenceEfficacy indexOral formulationLDL-CCardiometabolic endpointsPrimary outcomeSecondary outcomesBlood pressurePeptide-1Controlled TrialsSemaglutideObesitySystematic reviewT2D
Academic Achievements & Community Involvement
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Activities
activity National Institutes of Health (NIH)
06/01/2023 - PresentPeer Review Groups and Grant Study SectionsRevieweractivity JACC
02/01/2024 - PresentJournal ServiceAssociate Editoractivity American Heart Association
07/01/2021 - PresentProfessional OrganizationsFellowactivity JACC
07/01/2024 - PresentJournal ServiceAssociate Editoractivity American College of Cardiology
03/01/2025 - PresentProfessional OrganizationsFellow
Honors
honor Fellow
03/01/2025National AwardAmerican College of CardiologyDetailsUnited Stateshonor Office of Health Equity Research Award for Yale Research Excellence, Finalist
02/23/2024Yale School of Medicine AwardOffice of Health Equity Research, Yale School of MedicineDetailsUnited Stateshonor Office of Health Equity Research Award for Yale Research Excellence
02/01/2023Yale University AwardOffice of Health Equity Research, Yale School of MedicineDetailsUnited Stateshonor The John Laragh Research Award
07/29/2022National AwardAmerican Journal of HypertensionDetailsUnited Stateshonor Batten Fellowship Award
07/01/2022Regional AwardSentara FoundationDetailsUnited States
Teaching & Mentoring
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Mentoring
Chungsoo Kim, PharmD/PhD
Postdoc2024 - PresentIvan Wu
Postgrad associate2024 - PresentAdith Arun
Medical student2024 - PresentXin Xin
Graduate student2023 - 2024
News
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News
- June 03, 2026
AHA Award Supports Lu’s Research on GLP-1 Medications and CKM
- April 28, 2026
Choosing Safer Diabetes Medications for Older Adults
- February 26, 2026Source: Healio - Cardiology Today (with Yuan Lu)
Traditional Chinese mind-body practice improves blood pressure
- July 14, 2025Source: Cardiologytoday
Delays in Hypertension Diagnosis May Hold Up Treatment, Increase CVD Risk
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Yale Center for Outcomes Research and Evaluation
Academic Office
195 Church Street, Fl 5th
New Haven, CT 06510