Taylor Intihar, MS
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Research Assistant 1, HSS
Biography
Taylor completed her undergraduate degree at the University of Minnesota and her Master's in Biology at the University of Saint Joseph. Before joining the Knauert lab in 2019, Taylor was part of a University of Minnesota lab that focused on the molecular pathways involved in Huntington’s disease. In her spare time, Taylor enjoys distance running, DIY projects, and spending time with her two cats.
Education & Training
- MS
- University of St. Joseph, Biology (2022)
- BA
- University of Minnesota, Physiology (2019)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Taylor Intihar's published research.
Publications Timeline
A big-picture view of Taylor Intihar's research output by year.
Melissa Knauert, MD, PhD
Henry Yaggi, MD, MPH
Nancy Schmieder Redeker, RN, MSN, PhD, FAHA, FAAN
Shyoko Honiden, MD, MS
13Publications
87Citations
Publications
2024
Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study
Powierza C, Doyle M, Wasden K, Intihar T, Korwin A, Honiden S, Knauert M. Early goal enteral nutrition associated with decreased in-hospital death in mechanically ventilated critically ill adults: a retrospective cohort study. BMJ Open Respiratory Research 2024, 11: e001962. PMID: 38749534, PMCID: PMC11097881, DOI: 10.1136/bmjresp-2023-001962.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsEarly enteral nutritionIn-hospital deathCritically ill adultsRetrospective cohort studyDays of intubationEnteral nutritionIll adultsAdult patientsCohort studyAssociated with decreased in-hospital deathsMechanically ventilated critically ill adultsGoal enteral nutritionIncreased hospital dischargeInitiation of ENCritically ill adult patientsMechanically ventilated adult patientsIncidence of in-hospital deathMedical intensive care unitAssociated with significant improvementsIll adult patientsDose of ENIntensive care unitClinical outcomesImprove mortalityPrimary outcome
2023
0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICU
Lukas M, Doyle M, Intihar T, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0841 Feasibility of Actigraphy during a Daytime Bright Pilot Study in the Medical ICU. Sleep 2023, 46: a370-a371. DOI: 10.1093/sleep/zsad077.0841.Peer-Reviewed Original ResearchConceptsRest-activity patternsCircadian quotientMICU patientsPilot studyCosinor analysisStudy days 1Illness severity scoresCritical illnessMedical ICUMethods PatientsOngoing RCTsMean ageSeverity scorePatient outcomesActigraphy recordingsPatientsDay 1Patient careCircadian disruptionResults ThirteenActigraphyTotal recordingCircadian alignmentCircadian misalignmentMesor0842 Feasibility of daytime bright light exposure and urinary 6-sulfatoxymelatonin profiling in the medical ICU: A pilot study
Intihar T, Doyle M, Lukas M, Wright K, Redeker N, Pisani M, Yaggi H, Knauert M. 0842 Feasibility of daytime bright light exposure and urinary 6-sulfatoxymelatonin profiling in the medical ICU: A pilot study. Sleep 2023, 46: a371-a371. DOI: 10.1093/sleep/zsad077.0842.Peer-Reviewed Original ResearchConceptsMedical intensive care unitMICU patientsDaytime bright light exposureStudy days 1Intensive care unitIllness severity scoresBright light exposureWarrants further investigationCircadian outcomesMedical ICUCritical illnessIll patientsOngoing RCTsCare unitCircadian timingMean ageMelatonin useCircadian phaseSeverity scorePilot trialSufficient urinePatientsStudy daysBright lightDay 10846 Prevalence of Obstructive Sleep Apnea Among Medical ICU Patients
Ehrenberg M, Kongpakpaisarn K, Intihar T, Doyle M, Knauert M. 0846 Prevalence of Obstructive Sleep Apnea Among Medical ICU Patients. Sleep 2023, 46: a373-a373. DOI: 10.1093/sleep/zsad077.0846.Peer-Reviewed Original ResearchConceptsPre-existing OSAObstructive sleep apneaHigh clinical suspicionMICU patientsOSA diagnosisClinical suspicionSleep apneaMedical intensive care unit patientsSeverity of OSAIntensive care unit patientsAcute respiratory failureMedical ICU patientsProspective observational studyCare unit patientsPast medical historyAPACHE II severityBody mass indexElectronic medical recordsRespiratory failureChart reviewClinical characteristicsICU populationOSA patientsPatient demographicsUnit patientsTumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease
Mansky R, Greguske E, Yu D, Zarate N, Intihar T, Tsai W, Brown T, Thayer M, Kumar K, Gomez-Pastor R. Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease. Cell Reports 2023, 42: 112198. PMID: 36867535, PMCID: PMC10128052, DOI: 10.1016/j.celrep.2023.112198.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMajor transcription factorTumor suppressor p53Huntington's diseaseHtt aggregationTranscription factorsE3 ligase MDM2Protein degradationSuppressor p53Reciprocal regulationMutant HttP53 stabilizationMolecular differencesCell proliferationHSF1Neurodegenerative diseasesP53Most cancersNeurodegenerationP53 deletionTranscriptionDegradationDeletionAbundanceHTT
2022
INFLUENCE OF DEMOGRAPHIC FACTORS ON RESEARCH PARTICIPATION
SAMOJEDNY V, INTIHAR T, KNAUERT M. INFLUENCE OF DEMOGRAPHIC FACTORS ON RESEARCH PARTICIPATION. CHEST Journal 2022, 162: a1479. DOI: 10.1016/j.chest.2022.08.1246.Peer-Reviewed Original Research0583 Tolerance and feasibility of daytime bright light in medical intensive care unit patients
Intihar T, Samojedny V, Korwin A, Knauert M. 0583 Tolerance and feasibility of daytime bright light in medical intensive care unit patients. Sleep 2022, 45: a256-a257. DOI: 10.1093/sleep/zsac079.580.Peer-Reviewed Original ResearchConceptsMICU patientsCritical illnessMedical ICUControl trialChronic Health Evaluation II scoreMedical intensive care unit patientsIntensive care unit patientsMean patient ageCare unit patientsSeverity of illnessBright light exposureRandomized control trialOngoing randomized control trialAcute PhysiologyII scoreUsual carePatient ageUnit patientsIll patientsBright-light interventionSixteen patientsPoor outcomeClinical investigationBright lightPatients
2021
Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density
Zarate N, Intihar T, Yu D, Sawyer J, Tsai W, Syed M, Carlson L, Gomez-Pastor R. Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density. International Journal Of Molecular Sciences 2021, 22: 13113. PMID: 34884918, PMCID: PMC8657899, DOI: 10.3390/ijms222313113.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHeat shock transcription factor 1PSD-95 levelsPSD-95 expressionPSD-95Huntington's diseaseShock transcription factor 1Synaptic protein levelsFactor 1Heat shock factor 1Direct regulatory relationshipIonotropic glutamate receptorsAge-dependent mannerShock factor 1Protein homeostasisWT miceAcute reductionSynaptic dysfunctionGene regulationTranscription factor 1Synaptic densityProtein essentialSynaptic punctaGlutamate receptorsBehavioral deficitsExcitatory synapsesLIGHT SPECTRA: AN IMPORTANT CONSIDERATION FOR CIRCADIAN ALIGNMENT IN THE MEDICAL ICU
Wasden K, Intihar T, Knauert M. LIGHT SPECTRA: AN IMPORTANT CONSIDERATION FOR CIRCADIAN ALIGNMENT IN THE MEDICAL ICU. CHEST Journal 2021, 160: a2425. DOI: 10.1016/j.chest.2021.07.2096.Peer-Reviewed Original ResearchLIGHT PATTERNS OF THE MEDICAL ICU: ARE WE DISRUPTING CIRCADIAN RHYTHMS?
Intihar T, Wasden K, Knauert M. LIGHT PATTERNS OF THE MEDICAL ICU: ARE WE DISRUPTING CIRCADIAN RHYTHMS? CHEST Journal 2021, 160: a2424. DOI: 10.1016/j.chest.2021.07.2095.Peer-Reviewed Original Research
Academic Achievements and Community Involvement
honor Third place winner of the 2021 American College of Chest Physicians Top 5 Poster Awards
Regional AwardLight patterns of the medical intensive care unit: are we disrupting circadian rhythms?Details11/16/2021United Statesactivity Light patterns of the medical intensive care unit: are we disrupting circadian rhythms?
Poster PresentationLight patterns of the medical intensive care unit: are we disrupting circadian rhythms?Details01/01/2021 - PresentVirtual Poster PresentationSponsored by 2021 American College of Chest Physicians Annual Meetingactivity Intermittent feeding in mechanically ventilated medical intensive care unit patients: preliminary outcomes.
Oral PresentationIntermittent feeding in mechanically ventilated medical intensive care unit patients: preliminary outcomes.Details01/01/2021 - PresentVirtual Oral PresentationSponsored by University of Saint Joseph Annual Research Symposiumhonor University of Minnesota College of Liberal Arts National Conference of Undergraduate Research Travel Award
Other AwardDetails01/01/2019United Stateshonor University of Minnesota Undergraduate Research Travel Award
Other AwardDetails01/01/2019United States