Robert Safirstein, MD
Professor Emeritus of Medicine (Nephrology)Cards
About
Research
Publications
2025
Acute kidney injury markers in pediatric pancreatitis: Differentiating disease states and assessing severity
Garlapally V, Guo X, Hornung L, Delgado K, Cruz‐Monserrate Z, Safirstein R, Gorelick F, Desir G, Goldstein S, Abu‐El‐Haija M. Acute kidney injury markers in pediatric pancreatitis: Differentiating disease states and assessing severity. Journal Of Pediatric Gastroenterology And Nutrition 2025 PMID: 41384696, DOI: 10.1002/jpn3.70285.Peer-Reviewed Original ResearchAcute kidney injuryChronic pancreatitisAcute pancreatitisMild APUrinary NGALCystatin CEnzyme-linked immunosorbent assayAP patientsKIM-1Kidney functionAcute kidney injury markersPlasma KIM-1AP subjectsKidney injury markersPlasma cystatin CGlomerular filtration rateDifferentiate disease statesModerate/severe APPediatric pancreatitisPediatric APAP severityPediatric patientsPlasma creatinineKidney injuryInjury markersRenalase Activates Mitochondrial Leak Metabolism to Repair Mitochondrial Damage and Promote Cell Survival
Guo X, Chen R, Shugrue C, Chen T, M'Saad O, Tian Y, Gorelick F, Bewersdorf J, Safirstein R, Jonas E, Desir G. Renalase Activates Mitochondrial Leak Metabolism to Repair Mitochondrial Damage and Promote Cell Survival. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025n295szsg. DOI: 10.1681/asn.2025n295szsg.Peer-Reviewed Original ResearchMacrophages Derived from Renalase (RNLS) and Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 1 (Apobec1) Knockout Mice Fail to Rescue Cisplatin (CP)-Induced AKI
Guo X, Xu L, Velazquez H, Chen T, Safirstein R, Desir G. Macrophages Derived from Renalase (RNLS) and Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 1 (Apobec1) Knockout Mice Fail to Rescue Cisplatin (CP)-Induced AKI. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.20259z5cjmew. DOI: 10.1681/asn.20259z5cjmew.Peer-Reviewed Original ResearchRenalase, HIV viremia, and all-cause mortality in people with and without HIV
Chang J, So-Armah K, Guo X, Kundu S, Safirstein R, Marconi V, Freiberg M, Brown S, Justice A, Desir G. Renalase, HIV viremia, and all-cause mortality in people with and without HIV. AIDS 2025, 39: 1490-1494. DOI: 10.1097/qad.0000000000004195.Peer-Reviewed Original Research
2024
Macrophage Infusion Rescues Cisplatin (CP)-Induced AKI
Guo X, Xu L, Velazquez H, Chen T, Safirstein R, Desir G. Macrophage Infusion Rescues Cisplatin (CP)-Induced AKI. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024psy855fx. DOI: 10.1681/asn.2024psy855fx.Peer-Reviewed Original ResearchCOMBINED EFFECTS OF CHILD AND ADULT ELEVATED BLOOD PRESSURE ON ADULT SUBCLINICAL KIDNEY DAMAGE AND ALBUMINURIA: A 36-YEAR PROSPECTIVE COHORT STUDY
Wang Y, Jia H, Du M, Sun Y, Wang D, Hu G, Man Z, Chu C, Desir G, Safirstein R, Zheng X, Mu J. COMBINED EFFECTS OF CHILD AND ADULT ELEVATED BLOOD PRESSURE ON ADULT SUBCLINICAL KIDNEY DAMAGE AND ALBUMINURIA: A 36-YEAR PROSPECTIVE COHORT STUDY. Journal Of Hypertension 2024, 42: e204. DOI: 10.1097/01.hjh.0001021508.55729.ea.Peer-Reviewed Original ResearchPersistently elevated BPUrinary albumin-to-creatinine ratioAlbumin-to-creatinine ratioElevated BPSubclinical kidney damageIncreased riskBlood pressureAdult BPCreatinine ratioElevated urinary albumin-to-creatinine ratioEffects of childrenParticipants aged 6Self-reported useKidney damageRisk of chronic kidney diseaseAssociated with increased riskAssociated with increased risk of chronic kidney diseaseChildhood elevated BPNational Health Commission of the People's Republic of ChinaRisk of albuminuriaElevated blood pressureChronic kidney diseaseChildhood to adulthoodCohort studyLongitudinal cohort
2023
APOBEC-1 deletion enhances cisplatin-induced acute kidney injury
Guo X, Blanc V, Davidson N, Velazquez H, Chen T, Moledina D, Moeckel G, Safirstein R, Desir G. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Scientific Reports 2023, 13: 22255. PMID: 38097707, PMCID: PMC10721635, DOI: 10.1038/s41598-023-49575-3.Peer-Reviewed Original ResearchmRNA Editing via the Apobec1 Gene Promotes Recovery from AKI
Guo X, Velazquez H, Xu L, Cheng Z, Chen T, Tian Y, Bewersdorf J, Blanc V, Davidson N, Safirstein R, Desir G. mRNA Editing via the Apobec1 Gene Promotes Recovery from AKI. Journal Of The American Society Of Nephrology 2023, 34: 451-451. DOI: 10.1681/asn.20233411s1451b.Peer-Reviewed Original ResearchRenalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms
Guo X, Chen R, Chen T, Safirstein R, Jonas E, Desir G. Renalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms. Journal Of The American Society Of Nephrology 2023, 34: 117-117. DOI: 10.1681/asn.20233411s1117b.Peer-Reviewed Original Research
2022
Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI
Guo X, Xu L, Velazquez H, Chen T, Blanc V, Davidson N, Moeckel G, Safirstein R, Desir G. Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI. Journal Of The American Society Of Nephrology 2022, 33: 359-360. DOI: 10.1681/asn.20223311s1359e.Peer-Reviewed Original Research