John Hwa, MD, PhD, FRACP
Professor of Medicine (Cardiology)Cards
About
Research
Overview
The Hwa Laboratory research interests focuses on platelet metabolic reprogramming under stress conditions (e.g. hyperglycemia, oxidative stress) leading to thrombosis and critical intercellular communication with such cells as endothelial cells, vascular smooth muscle cells, and T-cells. Platelets play key roles in the regulation of vascular stress response, including hemostasis, immunoregulation, initiation of repair, and cessation of the repair process. Defective platelets thus contributes to vascular pathology including thromboinflammation, intimal hyperplasia, aneurysm formation, and immune dysregulation.
Our current studies can be broadly divided into the following major areas.
1) Platelet metabolic reprogramming in response to stress and aging
2) Platelet communication to other cells in health and disease
3) The Yale cardiovascular tissue repository collaborative effort
Medical Subject Headings (MeSH)
Academic Achievements & Community Involvement
News & Links
Media
- Confocal and electron microscopy demonstrating whole platelet uptake by a vascular smooth muscle cell
- Coronary angiogram, DNA sequence, and structural homology data for an R212C patient
News
- September 30, 2024
Pepper Center Awards Drive Aging and Dementia Studies
- August 08, 2024Source: Everyday Health
Artificial Sweetener Erythritol (Truvia) May Raise Heart Attack Risk
- May 19, 2024Source: The Guardian
‘It was smart to marry the competition’: meet the ‘power couples’ who work together
- April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions