Herta Chao, MD, PhD
Professor of Internal Medicine (Medical Oncology)DownloadHi-Res Photo
Cards
Appointments
Medical Oncology and Hematology
Primary
Additional Titles
Deputy Director at the VA Comprehensive Cancer Center, Section of Hematology/Oncology, VA Connecticut Healthcare System
Contact Info
Appointments
Medical Oncology and Hematology
Primary
Additional Titles
Deputy Director at the VA Comprehensive Cancer Center, Section of Hematology/Oncology, VA Connecticut Healthcare System
Contact Info
Appointments
Medical Oncology and Hematology
Primary
Additional Titles
Deputy Director at the VA Comprehensive Cancer Center, Section of Hematology/Oncology, VA Connecticut Healthcare System
Contact Info
About
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Titles
Professor of Internal Medicine (Medical Oncology)
Positions outside Yale
Deputy Director at the VA Comprehensive Cancer Center, Section of Hematology/Oncology, VA Connecticut Healthcare System
Appointments
Medical Oncology and Hematology
ProfessorPrimary
Other Departments & Organizations
- Developmental Therapeutics
- Internal Medicine
- Medical Oncology and Hematology
- MR Core
- Yale Cancer Center
- Yale Ventures
Education & Training
- Combined Residency
- Yale University, School of Medicine (2003)
- Postdoctoral Research Fellow
- Dana-Farber Cancer Institute (1999)
- Pediatric Intern
- University of Freiburg (1996)
- PhD
- Max Planck Institut, Neuroscience (1995)
- MD
- University of Goettingen, School of Medicine (1994)
Board Certifications
Hematology (Internal Medicine)
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2016
Medical Oncology
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2016
- Original Certification Date
- 2006
Pediatrics
- Certification Organization
- AB of Pediatrics
- Original Certification Date
- 2004
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2013
- Original Certification Date
- 2003
Research
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Overview
Medical Research Interests
Clinical Trial; Lung Neoplasms; Medical Oncology; Prostatic Neoplasms
ORCID
0000-0002-4827-6757
Research at a Glance
Yale Co-Authors
Frequent collaborators of Herta Chao's published research.
Publications Timeline
A big-picture view of Herta Chao's research output by year.
Research Interests
Research topics Herta Chao is interested in exploring.
Chiang-Shan Ray Li, MD, PhD
Shefali Chaudhary
Michal Rose, MD
Jaime Ide, PhD
Sheng Zhang, PhD
Barbara Ehrlich, PhD
27Publications
616Citations
Prostatic Neoplasms
Lung Neoplasms
Publications
2025
Proteome-Based Plasma Biomarkers for Cognitive Dysfunction in an Androgen Deprivation Model
Singh V, Verma S, Shankar E, Swain D, Willard B, Chao H, Li C, Lee Z, MacLennan G, Ponsky L, Gupta S. Proteome-Based Plasma Biomarkers for Cognitive Dysfunction in an Androgen Deprivation Model. Molecular Neurobiology 2025, 63: 201. PMID: 41315084, DOI: 10.1007/s12035-025-05548-3.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAndrogen deprivation therapyCognitive dysfunctionControl miceOral gavage 5 daysProstate cancer patientsAttention deficitGavage 5 daysBrain regionsCognitive functionEvaluation of biomarkersNeurotypical agingCognitive declineCognitive impactPositron emission tomographyDeprivation therapyEnzalutamide treatmentNonsteroidal antiandrogenProstate cancerNano-liquid chromatography tandem mass spectrometryNeuronal densityBehavioral changesPrimary treatmentBALB/c miceCancer patientsMouse modelImaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review
Chaudhary S, Chao H, Agarwal K, Gupta S, Li C. Imaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review. Neuroscience & Biobehavioral Reviews 2025, 176: 106270. PMID: 40578495, PMCID: PMC12239030, DOI: 10.1016/j.neubiorev.2025.106270.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFunctional brain changesBrain changesMagnetic resonance imagingCognitive declineWhite matter deficitsImaging marker of neuroinflammationFunctional brain impairmentAlzheimer's diseaseImpact of neuroinflammationDiffusion tensor imagingMarkers of neuroinflammationFunctional connectivityBrain impairmentAssessment of blood-brain barrierNeural markersBody of researchDevelopment of Alzheimer's diseaseTensor imagingBlood-brain barrierOlder adultsGray matterNeuroinflammatory processesMagnetization transfer imagingStructural imagingRelated dementiaCancer-Related Cognitive Impairment: A Practical Guide for Oncologists
Zhang Y, Kesler S, Dietrich J, Chao H. Cancer-Related Cognitive Impairment: A Practical Guide for Oncologists. JCO Oncology Practice 2025, 21: 1377-1381. PMID: 40043223, PMCID: PMC12353510, DOI: 10.1200/op-24-00953.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Age-related reduction in anxiety and neural encoding of negative emotional memory
Chaudhary S, Zhang S, Chen Y, Dominguez J, Chao H, Li C. Age-related reduction in anxiety and neural encoding of negative emotional memory. Frontiers In Aging Neuroscience 2024, 16: 1375435. PMID: 39021704, PMCID: PMC11252031, DOI: 10.3389/fnagi.2024.1375435.Peer-Reviewed Original ResearchCitationsConceptsNegative emotional memoriesSpielberger State-Trait Anxiety InventoryEmotional memoryAge-related reductionSpielberger State-Trait Anxiety Inventory scoresWhole-brain regressionNegative emotional imagesState-Trait Anxiety InventoryTrait Anxiety InventoryAge-related differencesSignal detection theoryMemory taskNeutral imagesAge-related changesEmotional imagesAnxiety InventoryMediation analysisAnxietyPost-scanCortical activityNeural encodingState scoresMemoryOlder adultsDetection theoryMP41-20 POTENTIAL BIOMARKERS FOR COGNITIVE IMPAIRMENT ASSOCIATED WITH ANDROGEN DEPRIVATION
Verma S, Singh V, Nagampalli V, Chao H, Gupta S. MP41-20 POTENTIAL BIOMARKERS FOR COGNITIVE IMPAIRMENT ASSOCIATED WITH ANDROGEN DEPRIVATION. Journal Of Urology 2024, 211: e682. DOI: 10.1097/01.ju.0001008896.93851.5b.20.Peer-Reviewed Original ResearchLigand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients
Verma S, Singh V, Nagampalli V, Ponsky L, Li C, Chao H, Gupta S. Ligand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients. Molecular Carcinogenesis 2024, 63: 1051-1063. PMID: 38482990, PMCID: PMC11096008, DOI: 10.1002/mc.23708.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAndrogen deprivation therapyN-methyl-D-aspartate receptorsGamma-aminobutyric acidLigand-gated ion channelsType 1 angiotensin II receptorGlial cellsAndrogen signaling inhibitorsProstate cancer cell culture modelHigher risk of cognitive dysfunctionProstate cancer patientsPotential biomarkersBrain-derived neurotrophic factorCognitive dysfunctionIon channelsProtein-protein interaction network analysisAngiotensin II receptorsNuclear receptor subfamily 3 group C member 1Real-time polymerase chain reaction assayBrain glial cellsCytokine-cytokine receptor interactionCancer cell culture modelsAnalysis of genesGene-disease associationsInteraction network analysisPolymerase chain reaction assayAndrogen deprivation increases frontopolar cortical thickness in prostate cancer patients: an effect of early neurodegeneration?
Chaudhary S, Roy A, Summers C, Ahles T, Li C, Chao H. Androgen deprivation increases frontopolar cortical thickness in prostate cancer patients: an effect of early neurodegeneration? American Journal Of Cancer Research 2024, 14: 3652-3664. PMID: 39113873, PMCID: PMC11301281, DOI: 10.62347/wola8904.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFrontopolar cortexCortical thicknessWorking memoryAndrogen deprivation therapyN-back performanceN-back taskProstate cancer patientsYears of educationPublished routinesNeural consequencesBrain changesBrain morphologyMediation analysisCT changesConsequences of androgen deprivation therapyMonths of androgen deprivation therapyTestosterone level changesImpact of androgen deprivation therapyCancer patientsNon-metastatic prostate cancerTestosterone levelsResponse to androgen deprivationLong duration of treatmentBrain imagingNeurodegenerative changes
2023
Sex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala
Chaudhary S, Hu S, Hu K, Dominguez J, Chao H, Li C. Sex differences in the effects of trait anxiety and age on resting-state functional connectivities of the amygdala. Journal Of Affective Disorders Reports 2023, 14: 100646. PMID: 38105798, PMCID: PMC10723810, DOI: 10.1016/j.jadr.2023.100646.Peer-Reviewed Original ResearchCitationsConceptsResting-state functional connectivityAmygdala resting-state functional connectivityTrait anxietyFunctional connectivitySex differencesInferior temporal gyrusCalcarine cortexTask-based dataNeural basisIndividual differencesEmotional traitsSupramarginal gyrusEmotional disordersTemporal gyrusNeural markersPosterior insulaAnxietyEffect of ageGyrusIndependent samplesMultiple regressionCorrelatesAmygdalaResults AnxietyCortexAge-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing
Chaudhary S, Zhang S, Zhornitsky S, Chen Y, Chao H, Li C. Age-related reduction in trait anxiety: Behavioral and neural evidence of automaticity in negative facial emotion processing. NeuroImage 2023, 276: 120207. PMID: 37263454, PMCID: PMC10330646, DOI: 10.1016/j.neuroimage.2023.120207.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFaster reaction timesNegative emotionsAge-related declineEmotional stimuliTrait anxietyAge-related reductionReaction timeEmotion regulation literatureSalient emotional stimuliPositive emotional stimuliFacial emotion processingPrefrontal cortical responsesRostral anterior cingulate cortexWhole-brain regressionAnterior cingulate activityDefault mode networkAnterior cingulate cortexEmotion regulationNeural evidenceEmotion processingDorsolateral PFCStimulus registrationDiminished anxietyPsychophysiological interactionEmotional circuitsDoes ADT Influence the Risk of Suicidal Ideation among US Veteran Prostate Cancer Patients Pre-Exposed to PTSD?
Brahmbhatt S, Chao H, Verma S, Gupta S. Does ADT Influence the Risk of Suicidal Ideation among US Veteran Prostate Cancer Patients Pre-Exposed to PTSD? Cancers 2023, 15: 2739. PMID: 37345076, PMCID: PMC10216772, DOI: 10.3390/cancers15102739.Peer-Reviewed Original ResearchAltmetric
Academic Achievements & Community Involvement
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Honors
honor VISN1 Clinical Service Line Award, Medicine Service Line
10/02/2017Regional AwardDepartment of Veterans AffairsDetailsUnited Stateshonor David S. Fischer, MD award for outstanding teaching & mentoring of fellows in Medical Oncology
06/16/2014Yale School of Medicine AwardYale School of Medicine and Yale Comprehensive Cancer CenterDetailsUnited Stateshonor AACR Career Development
04/24/2006National AwardAmerican Association for Cancer ResearchDetailsUnited Stateshonor Research Fellowship of the “Deutsche Forschungsgemeinschaft”
09/02/1998, 09/02/1997, 09/02/1996International AwardGerman Research AssociationDetailsGermanyhonor Doctoral thesis "magna cum laude"
01/30/1995International AwardUniversity of Goettingen and Max Planck InstitutDetailsGermany
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