Edward Kaftan, PhD
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Cards
Appointments
Medical Oncology
Primary
Titles
Associate Director, Research Affairs, Yale Cancer Center
Contact Info
Appointments
Medical Oncology
Primary
Titles
Associate Director, Research Affairs, Yale Cancer Center
Contact Info
Appointments
Medical Oncology
Primary
Titles
Associate Director, Research Affairs, Yale Cancer Center
Contact Info
About
Titles
Senior Research Scientist
Associate Director, Research Affairs, Yale Cancer CenterAppointments
Medical Oncology
Senior Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- Yale University (1997)
- PhD
- University of Connecticut (1996)
- BS
- Renselaer Polytechnic Institute, Biology (1989)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Edward Kaftan's published research.
Publications Timeline
A big-picture view of Edward Kaftan's research output by year.
Roy S. Herbst, MD, PhD
David Rimm, MD, PhD
Kurt Schalper, MD, PhD
Anna Wurtz
Anne Chiang, MD, PhD
Barbara Ehrlich, PhD
10Publications
157Citations
Publications
2017
Measurement of PD-1, TIM-3 and LAG-3 protein in non-small cell lung carcinomas (NSCLCs) with acquired resistance to PD-1 axis blockers.
Datar I, Mani N, Henick B, Wurtz A, Kaftan E, Herbst R, Rimm D, Gettinger S, Politi K, Schalper K. Measurement of PD-1, TIM-3 and LAG-3 protein in non-small cell lung carcinomas (NSCLCs) with acquired resistance to PD-1 axis blockers. Journal Of Clinical Oncology 2017, 35: e14611-e14611. DOI: 10.1200/jco.2017.35.15_suppl.e14611.Peer-Reviewed Original ResearchCitationsConceptsNon-small cell lung carcinomaTim-3PD-1LAG-3T cellsInhibitory receptorsAdvanced non-small cell lung carcinomaPD-1 axis blockadeHigh TIM-3Immune suppressive pathwaysImmune inhibitory receptorsCell lung carcinomaMembranous staining patternPre-treatment samplesWhole tissue sectionsWhole tumor areaClinical responseMost patientsAxis blockadeLow levelsLung carcinomaT lymphocytesMultiplex immunofluorescenceHigh levelsSuppressive pathwaysP3.02c-070 Combination Immunotherapy with MEK Inhibitor for Treatment of Kras-Mutant Lung Cancer in Animal Model Topic: IT Biomarkers
Lee J, Zhang Y, Choi J, Sharma R, Park H, Kaftan E, Papadimitrakopoulou V, Herbst R, Koo J. P3.02c-070 Combination Immunotherapy with MEK Inhibitor for Treatment of Kras-Mutant Lung Cancer in Animal Model Topic: IT Biomarkers. Journal Of Thoracic Oncology 2017, 12: s1319. DOI: 10.1016/j.jtho.2016.11.1865.Peer-Reviewed Original ResearchCitations
2016
Objective measurement and significance of PD-L1, B7-H3, B7-H4 and TILs in small cell lung cancer (SCLC).
Schalper K, Carvajal-Hausdorf D, McLaughlin J, Altan M, Chiang A, Velcheti V, Kaftan E, Zhang J, Lu L, Rimm D, Han B, Lu H, Zhao H, Herbst R. Objective measurement and significance of PD-L1, B7-H3, B7-H4 and TILs in small cell lung cancer (SCLC). Journal Of Clinical Oncology 2016, 34: 8566-8566. DOI: 10.1200/jco.2016.34.15_suppl.8566.Peer-Reviewed Original ResearchCitations
2010
Purinergic receptor-mediated morphological changes in microglia are transient and independent from inflammatory cytokine release.
McIlvain HB, Ma L, Ludwig B, Manners MT, Martone RL, Dunlop J, Kaftan EJ, Kennedy JD, Whiteside GT. Purinergic receptor-mediated morphological changes in microglia are transient and independent from inflammatory cytokine release. European Journal Of Pharmacology 2010, 643: 202-10. PMID: 20621081, DOI: 10.1016/j.ejphar.2010.06.046.Peer-Reviewed Original ResearchDevelopment of a FLIPR assay for the simultaneous identification of MrgD agonists and antagonists from a single screen.
Ajit SK, Pausch MH, Kennedy JD, Kaftan EJ. Development of a FLIPR assay for the simultaneous identification of MrgD agonists and antagonists from a single screen. Journal Of Biomedicine & Biotechnology 2010, 2010 PMID: 20936132, PMCID: PMC2947157, DOI: 10.1155/2010/326020.Peer-Reviewed Original Research
1997
Inositol 1,4,5-Trisphosphate (InsP3) and Calcium Interact to Increase the Dynamic Range of InsP3 Receptor-dependent Calcium Signaling
Kaftan E, Ehrlich B, Watras J. Inositol 1,4,5-Trisphosphate (InsP3) and Calcium Interact to Increase the Dynamic Range of InsP3 Receptor-dependent Calcium Signaling. The Journal Of General Physiology 1997, 110: 529-538. PMID: 9348325, PMCID: PMC2229389, DOI: 10.1085/jgp.110.5.529.Peer-Reviewed Original ResearchCitations
1990
A mitochondrial protein fraction catalyzing transport of the K+ analog T1+.
Diwan JJ, Paliwal R, Kaftan E, Bawa R. A mitochondrial protein fraction catalyzing transport of the K+ analog T1+. FEBS Letters 1990, 273: 215-8. PMID: 1699808.Peer-Reviewed Original Research
Others
- Bowlby, M. R. and Kaftan, E.J. (2009) Sodium channel blockers for the treatment of chronic pain. In Structure, Function and Modulation of Neuronal Voltage-gated Ion Channels. Valentin Gribkoff and Leonard Kaczmarek , Editors.Peer-Reviewed Original Research
- Diwan, J.J., Haley, T., Kaftan, E., Joshi, S., and Sanadi, D. (1988) Isolation of a 53kDa protein from mitochondria which may have a role mediating K+ transport. EBEC Short Reports 5: 207.Peer-Reviewed Original Research
- Diwan, J.J., Paliwal, R., Kaftan, E., Costa, G., Joshi, S. (1991) A monovalent cation transport catalyst from rat liver mitochondria. Trends in Bioenergetics and Biomembranes 1:165-170.Peer-Reviewed Original Research
Academic Achievements and Community Involvement
honor Post-Doctoral Award (Competitive renewal, July 2000-June 2001)
National AwardLalor FoundationDetails07/01/2000United Stateshonor Postdoctoral Award (April 1999-March 2000)
National AwardLalor FoundationDetails01/01/1999United Stateshonor Institutional Post-Doctoral National Research Service Award
National AwardNational Institutes of Health/NICHDDetails01/01/1999United Stateshonor Graduate Fellowship Award (1991-1996)
Yale University AwardUniversity of ConnecticutDetails01/01/1991United States
Links & Media
News
- July 27, 2022
New Appointments & Promotions Within Department of Internal Medicine
- September 08, 2021
Edward Kaftan Named Associate Cancer Center Director for Research Affairs at Yale Cancer Center
- February 04, 2021
Edward Kaftan Named Assistant Cancer Center Director for Translational Science at Yale Cancer Center
- July 08, 2020
Yale Cancer Center Awarded NIH SPORE Renewal for Lung Cancer Research