2023
Trends in and Factors Associated With Surgical Management for Closed Clavicle Fractures
Dhodapkar M, Modrak M, Halperin S, Joo P, Luo X, Grauer J. Trends in and Factors Associated With Surgical Management for Closed Clavicle Fractures. JAAOS Global Research And Reviews 2023, 7: e23.00226. PMID: 38149938, PMCID: PMC10752468, DOI: 10.5435/jaaosglobal-d-23-00226.Peer-Reviewed Original ResearchConceptsElixhauser Comorbidity IndexSurgical managementClavicle fracturesAnatomic locationFracture diagnosisClosed clavicle fractureMinority of patientsComorbidity indexAdult patientsClinical factorsPatient ageIndependent predictorsMultivariable analysisNonsurgical managementOpen reductionNonclinical factorsFirst diagnosisInternal fixationSurgical considerationsSuch injuriesPatientsStudy periodDiagnosisInsurance coverageFracturesUveitis
Heng J, Kombo N. Uveitis. Contemporary Surgical Clerkships 2023, 105-112. DOI: 10.1007/978-3-031-27327-8_7.ChaptersSecond Primary Malignancies of the Bones and Joints: More Common than Expected in Osteosarcoma Patients
Freedman I, Dowd H, Dhodapkar M, Halperin S, Grauer J. Second Primary Malignancies of the Bones and Joints: More Common than Expected in Osteosarcoma Patients. JAAOS Global Research And Reviews 2023, 7: e22.00275. PMID: 36695170, PMCID: PMC9875998, DOI: 10.5435/jaaosglobal-d-22-00275.Peer-Reviewed Original ResearchConceptsSecond primary malignanciesStandardized incidence ratiosOsteosarcoma survivorsPrimary malignancyCommon second primary malignancyNational Cancer Institute's SurveillanceEnd Results 18 databaseCommon primary bone tumorPrimary bone tumorsPopulation-level dataIncidence ratiosOverall incidenceOsteosarcoma patientsPatient populationExcess riskBone tumorsAnatomic locationLong-term eventsOsteosarcoma casesPatientsYoung adultsTumorsSoft tissueMalignancyOsteosarcoma
2022
Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants
Jang J, Lee S, Ko K, Abe S, Rahman S, Saito E, Islam R, Sawada N, Shu X, Koh W, Sadakane A, Tsuji I, Kim J, Oze I, Nagata C, Tsugane S, Cai H, Yuan J, Gao Y, Ozasa K, Matsuyama S, Kanemura S, Shin A, Ito H, Wada K, Sugawara Y, Chen Y, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Rothman N, Zheng W, Inoue M, Kang D, Park S. Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants. Cancer Epidemiology Biomarkers & Prevention 2022, 31: 1727-1734. PMID: 35793701, PMCID: PMC9489277, DOI: 10.1158/1055-9965.epi-22-0051.Peer-Reviewed Original ResearchConceptsBody mass indexNon-cardia gastric cancerGastric cancer riskIntestinal-type gastric cancerAssociation of underweightGastric cancerCancer riskHazard ratioMass indexCox proportional hazards regression modelProportional hazards regression modelsHazards regression modelsConfidence intervalsEarly-onset gastric cancerDiffuse-type gastric cancerCardia gastric cancerGastric cancer casesObesity groupUnderweight groupBMI groupsHistologic subtypeCohort participantsCancer casesAnatomic locationShaped associationsCharacterization of More Than a Third of a Million Toy-Related Fractures
Halperin SJ, Prenner S, Moore HG, Grauer JN. Characterization of More Than a Third of a Million Toy-Related Fractures. JAAOS Global Research And Reviews 2022, 6: e22.00013. PMID: 35245277, PMCID: PMC8896474, DOI: 10.5435/jaaosglobal-d-22-00013.Peer-Reviewed Original ResearchConceptsEmergency departmentNational Electronic Injury Surveillance SystemElectronic Injury Surveillance SystemWrists/hands/fingersUS Consumer Product Safety CommissionArm/elbowToes/feetInjury Surveillance SystemUS emergency departmentsConsumer Product Safety CommissionHand/fingerToy-related injuriesYearly incidenceNeck/headAnatomic locationOrthopaedic surgeonsMale subjectsSuch fracturesPubic regionPatient safetyIncidence increasesStudy periodInjurySafety CommissionIncidence
2021
Primary sinonasal large B cell lymphoma is as histopathologically heterogeneous as systemic large B cell lymphoma but may show subtype-specific tropism for specific sinonasal anatomic sites
Desai M, Sethi T, Yenamandra A, Morgan D, Thompson M, Reddy N, Kovach A. Primary sinonasal large B cell lymphoma is as histopathologically heterogeneous as systemic large B cell lymphoma but may show subtype-specific tropism for specific sinonasal anatomic sites. Journal Of Hematopathology 2021, 14: 269-275. DOI: 10.1007/s12308-021-00473-5.Peer-Reviewed Original ResearchLarge B-cell lymphomaB-cell lymphomaHigh-grade B-cell lymphomaCell lymphomaSinonasal tractDLBCL-NOSAnatomic sitesAnatomic locationExtranodal NK/T-cell lymphomaNK/T-cell lymphomaGerminal center B-cell phenotypeMaxillary sinus tumorsT-cell lymphomaB-cell phenotypeClassification of lymphomasNon-GCB tumorsStage IIEFemale patientsSinus tumorLymphoma characteristicsSitu hybridization studiesWHO criteriaNasopharyngeal diseaseWHO classificationVariable presentationBlind spots on CT imaging of the head: Insights from 5 years of report addenda at a single institution
Tu LH, Bokhari SAJ. Blind spots on CT imaging of the head: Insights from 5 years of report addenda at a single institution. Clinical Imaging 2021, 76: 189-194. PMID: 33957385, DOI: 10.1016/j.clinimag.2021.04.026.Peer-Reviewed Original ResearchConceptsCT headSingle institutionCT imagingCross-sectional studyExtracranial soft tissuesType of pathologyCarotid terminusDistal MCAAnatomic subsiteJugular bulbBrain parenchymaVascular lesionsCommon siteConsecutive reportsAnatomic locationParotid glandCSF spaceFrontal scalpOccipital boneOsseous structuresSoft tissue
2020
Orthopaedic Injuries Associated With Cell Phone Use Resulting in Emergency Department Visits: A 20-Year Analysis
Moore HG, Halperin SJ, Berson ER, Burroughs PJ, Paskhover B, Grauer JN. Orthopaedic Injuries Associated With Cell Phone Use Resulting in Emergency Department Visits: A 20-Year Analysis. Journal Of The American Academy Of Orthopaedic Surgeons 2020, 29: 571-579. PMID: 32947349, DOI: 10.5435/jaaos-d-20-00639.Peer-Reviewed Original ResearchConceptsOrthopedic injuriesED visitsAge groupsElectronic Injury Surveillance SystemSprains/strainsInjury Surveillance SystemStandard deviation ageProportion of injuriesEmergency Department DatabasesType of injuryPublic health educationDeviation ageEmergency departmentInjury typeDepartment databaseSuch injuriesInclusion criteriaAnatomic locationHealth educationInjuryCell phone useMarked increaseCommon typeBody partsPhone usePredicting outcomes following second intent healing of periocular surgical defects
Kibbi N, Khan Y, Leffell DJ, Christensen SR, Suozzi KC. Predicting outcomes following second intent healing of periocular surgical defects. Archives Of Dermatological Research 2020, 313: 483-489. PMID: 32833078, DOI: 10.1007/s00403-020-02122-w.Peer-Reviewed Original ResearchConceptsMohs micrographic surgeryMedial canthusSingle academic surgical centerAcademic surgical centerConclusionsThis retrospective studyMedial canthal lesionAverage defect diameterMethodsRetrospective analysisTumor characteristicsPeriocular tumorsRetrospective studyPoor outcomePeriocular lesionsSurgical centersMicrographic surgeryWorse outcomesAnatomic locationAimThe purposeScar outcomeLarge lesionsUpper eyelidEyelid marginLid marginSurgical defectsLower eyelidThyroid tissue outside the thyroid gland: Differential diagnosis and associated diagnostic challenges
Barbieri A, Prasad ML, Gilani SM. Thyroid tissue outside the thyroid gland: Differential diagnosis and associated diagnostic challenges. Annals Of Diagnostic Pathology 2020, 48: 151584. PMID: 32871503, DOI: 10.1016/j.anndiagpath.2020.151584.Peer-Reviewed Original ResearchConceptsDifferential diagnostic considerationsThyroid tissueThyroid glandLymph nodesDiagnostic challengeDifferential diagnosisDiagnostic considerationsLateral neck lymph nodesNeck lymph nodesRoutine daily practiceThyroglossal duct cystLocation of lesionsMalignant differential diagnosisDuct cystDefinitive diagnosisLingual thyroidAnatomic locationClinical settingThyroid folliclesDaily practiceDiagnosisParasitic nodulesGlandTissueHistologicTumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage
Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Muca E, Vollmar AKR, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage. Metabolites 2020, 10: 257. PMID: 32575361, PMCID: PMC7345993, DOI: 10.3390/metabo10060257.Peer-Reviewed Original ResearchColorectal cancerAnatomic locationTissue-specific biomarkersOrthogonal partial least squares discriminant analysisBlood samplesMetabolite biomarkersTumor tissueRight-sided colon cancerPatient blood samplesCRC patientsStudy cohortScreening regimensIndependent cohortUntargeted metabolomics analysisStage IColon cancerDisease influenceMetabolic consequencesDiscriminatory biomarkersNormal colonMetabolic signaturesPre-validation phaseBiomarker studiesBiomarkersCancerIntravascular Imaging for Venous Interventions
Brar V, Dhawan R, Secemsky E, Altin S, Klein A, Hyder O, Goldsweig A. Intravascular Imaging for Venous Interventions. Current Cardiovascular Imaging Reports 2020, 13: 19. DOI: 10.1007/s12410-020-09539-x.Peer-Reviewed Original ResearchIntravascular ultrasoundVenous interventionsVena cavaInferior vena cava filter placementVena cava filter placementTransjugular intrahepatic portosystemic shunt (TIPS) creationTransjugular liver biopsyCava filter placementIntravascular imagingInferior vena cavaSuperior vena cavaCross-sectional imagingPortosystemic Shunt CreationOptical coherence tomographyHigh-resolution cross-sectional imagingEndovenous interventionLiver biopsyVenous assessmentVenous pathologyFilter placementAnatomic locationShunt creationClinical landscapeCoherence tomographyDiagnostic studiesSex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype
Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. Scientific Reports 2020, 10: 4905. PMID: 32184446, PMCID: PMC7078199, DOI: 10.1038/s41598-020-61851-0.Peer-Reviewed Original ResearchConceptsRight-sided colon cancerColorectal cancerCRC patientsColon cancer metabolismPoor clinical outcomePatient colon tumorsAsparagine synthetase expressionNovel subphenotypesClinical outcomesAmino acid uptakePoor survivalLower incidenceAnatomic locationHigh incidenceTherapeutic targetColon cancerCancer Genomic AtlasClinical importanceColon tumorsTumor progressionAberrant metabolismNormal tissuesPatientsSubphenotypesAcid uptake
2019
Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness
Kibbi N, Zhang Y, Leffell DJ, Christensen SR. Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness. Journal Of The American Academy Of Dermatology 2019, 82: 1124-1130. PMID: 31712171, DOI: 10.1016/j.jaad.2019.10.079.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAminolevulinic AcidAnalysis of VarianceBiopsy, NeedleCarcinoma in SituCarcinoma, Squamous CellCohort StudiesDisease-Free SurvivalFemaleHumansImmunohistochemistryLogistic ModelsMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingPhotochemotherapyPrognosisRetrospective StudiesSkin NeoplasmsSurvival AnalysisTreatment OutcomeTumor BurdenConceptsCutaneous squamous cell carcinomaALA incubation timeSquamous cell carcinomaTumor diameterALA-PDTSubsequent recurrenceCell carcinomaAnatomic locationInitial complete response ratePhotodynamic therapyCases of SCCISMultivariate analysis factorsComplete response rateMedical record reviewEffectiveness of PDTPatient demographicsClinical responseMedian timeRetrospective reviewRecord reviewRetrospective studyTreatment detailsSingle institutionEffective treatmentResponse rateCharacteristics and anatomic distribution of early vs late stroke after cardiac surgery
Ivascu NS, Khan FM, Rahouma M, Hameed I, Abouarab A, Segal AZ, Gaudino MFL, Girardi LN. Characteristics and anatomic distribution of early vs late stroke after cardiac surgery. Journal Of Cardiac Surgery 2019, 34: 684-689. PMID: 31212394, DOI: 10.1111/jocs.14121.Peer-Reviewed Original ResearchConceptsLate strokeOperative mortalityCardiac surgeryEarly strokePerioperative strokeOpen cardiac surgeryTime of presentationOpen heart surgeryImpact of strokeWeill Cornell MedicinePerioperative variablesAdult patientsAnterior circulationEmbolic eventsSecondary outcomesCardiopulmonary bypassLikely etiologyAnatomic distributionHeart surgeryRisk factorsAnatomic locationHigh incidencePatientsSurgeryStroke
2018
Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker
Marino AC, Yang GJ, Tyrtova E, Wu K, Zaveri HP, Farooque P, Spencer DD, Bandt SK. Resting state connectivity in neocortical epilepsy: The epilepsy network as a patient-specific biomarker. Clinical Neurophysiology 2018, 130: 280-288. PMID: 30605890, DOI: 10.1016/j.clinph.2018.11.016.Peer-Reviewed Original ResearchConceptsLocalization related epilepsyEpilepsy networkSeizure onset locationSingle-patient levelCorrelated network activityPatient-specific biomarkersRelated epilepsyConnectivity patternsNeocortical epilepsyPatient levelSeizure onsetInterictal periodAnatomic locationPatientsPossible biomarkersState connectivityCortical regionsSingle-subject levelTopographic distributionCohortNetwork disorderBrain networksEpilepsyNetwork activityBiomarkers
2016
EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer
Beck TN, Georgopoulos R, Shagisultanova EI, Sarcu D, Handorf EA, Dubyk C, Lango MN, Ridge JA, Astsaturov I, Serebriiskii IG, Burtness BA, Mehra R, Golemis EA. EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer. Molecular Cancer Therapeutics 2016, 15: 2486-2497. PMID: 27507850, PMCID: PMC5522587, DOI: 10.1158/1535-7163.mct-16-0243.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6ErbB ReceptorsFemaleHead and Neck NeoplasmsHumansImmunohistochemistryKaplan-Meier EstimateMaleMiddle AgedModels, BiologicalNeoplasm StagingPapillomaviridaePapillomavirus InfectionsPhosphorylationPrognosisProtein Kinase InhibitorsReceptor, ErbB-2Retinoblastoma Binding ProteinsUbiquitin-Protein LigasesConceptsEpidermal growth factor receptorRetinoblastoma 1Neck squamous cell carcinomaExpression of EGFRSquamous cell carcinomaCDK4/6 inhibitor palbociclibSignificant survival differenceResponse predictive biomarkersHPV-negative HNSCCHigh epidermal growth factor receptorStratification of casesImportant therapeutic targetSynergistic inhibitory effectGrowth factor receptorCell cycle modulatorsCell carcinomaDisease stageInhibitor palbociclibHuman papillomavirusSurvival differencesHNSCC samplesTherapeutic decisionsHNSCC cellsAnatomic locationDrug combinationsRestless Legs Syndrome: Current Concepts about Disease Pathophysiology
Koo B, Bagai K, Walters A. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor And Other Hyperkinetic Movements 2016, 6: 401. DOI: 10.5334/tohm.322.Peer-Reviewed Original ResearchRestless legs syndromeBrain areasLegs syndromeSerotonergic systemCingulate cortexIron deficiencyStructural brain abnormalitiesPost-central gyrusWidespread brain areasSensory brain areasEnglish language papersRLS patientsSensorimotor disorderBrain abnormalitiesAnatomic locationDisease pathophysiologySecondary responseBrain regionsPathophysiologyConsistent findingLanguage papersCurrent conceptsOpioidsGlutamatergicDopaminergicRestless Legs Syndrome: Current Concepts about Disease Pathophysiology
Koo BB, Bagai K, Walters AS. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor And Other Hyperkinetic Movements 2016, 6: 401. PMID: 27536462, PMCID: PMC4961894, DOI: 10.7916/d83j3d2g.Peer-Reviewed Original ResearchRestless legs syndromeBrain areasLegs syndromeSerotonergic systemCingulate cortexIron deficiencyStructural brain abnormalitiesPost-central gyrusWidespread brain areasSensory brain areasEnglish language papersRLS patientsSensorimotor disorderBrain abnormalitiesAnatomic locationDisease pathophysiologySecondary responseBrain regionsPathophysiologyConsistent findingLanguage papersCurrent conceptsOpioidsGlutamatergicDopaminergic
2015
Pathologic leadpoint is uncommon in ileo-colic intussusception regardless of age
Rubinstein JC, Liu L, Caty MG, Christison-Lagay ER. Pathologic leadpoint is uncommon in ileo-colic intussusception regardless of age. Journal Of Pediatric Surgery 2015, 50: 1665-1667. PMID: 25858099, DOI: 10.1016/j.jpedsurg.2015.03.048.Peer-Reviewed Original ResearchConceptsIleo-colic intussusceptionBasis of ageOlder childrenAnatomic locationSmall bowel-small bowel intussusceptionNon-operative managementCases of intussusceptionBarium enema reductionOlder age groupsBowel intussusceptionOperative interventionCase seriesRetrospective reviewEnema reductionSubgroup analysisTreatment successIncreased frequencyIntussusceptionActual incidenceAge groupsAnecdotal experienceLeadpointAgePatientsChildren
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