2024
Efficacy and safety of prucalopride in patients with chronic idiopathic constipation stratified by age, body mass index, and renal function: a post hoc analysis of phase III and IV, randomized, placebo-controlled clinical studies
Lembo A, Staller K, Boules M, Feuerstadt P, Spalding W, Gabriel A, Youssef A, Xie Y, Terreri B, Cash B. Efficacy and safety of prucalopride in patients with chronic idiopathic constipation stratified by age, body mass index, and renal function: a post hoc analysis of phase III and IV, randomized, placebo-controlled clinical studies. Therapeutic Advances In Gastroenterology 2024, 17: 17562848241299731. PMID: 39664231, PMCID: PMC11632959, DOI: 10.1177/17562848241299731.Peer-Reviewed Original ResearchChronic idiopathic constipationBody mass indexSafety of prucalopridePlacebo-treated patientsRenal functionRenal impairmentEfficacy endpointIdiopathic constipationMass indexClinical studiesTreatment-related adverse eventsPlacebo-controlled clinical studyRenal impairment subgroupsMild renal impairmentModerate renal impairmentNormal renal functionProportion of patientsPost Hoc AnalysisUnderweight/healthy weightAdverse eventsPrucaloprideIII and IVSafety dataPatientsTreating adults
2022
Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy
Al’Aref S, Altibi A, Malkawi A, Mansour M, Baskaran L, Masri A, Rahmouni H, Abete R, Andreini D, Aquaro G, Barison A, Bogaert J, Camastra G, Carigi S, Carrabba N, Casavecchia G, Censi S, Cicala G, Conte E, De Cecco C, De Lazzari M, Di Giovine G, Di Roma M, Dobrovie M, Focardi M, Gaibazzi N, Gismondi A, Gravina M, Guglielmo M, Lanzillo C, Lombardi M, Lorenzoni V, Lozano-Torres J, Margonato D, Martini C, Marzo F, Masci P, Masi A, Memeo R, Moro C, Mushtaq S, Nese A, Palumbo A, Pavon A, Pedrotti P, Pepi M, Marra M, Pica S, Pradella S, Presicci C, Rabbat M, Raineri C, Rodriguez-Palomares J, Sbarbati S, Schoepf U, Squeri A, Sverzellati N, Symons R, Tat E, Timpani M, Todiere G, Valentini A, Varga-Szemes A, Volpe A, Fusini L, Guaricci A, Schwitter J, Pontone G. Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy. European Heart Journal - Cardiovascular Imaging 2022, 24: 472-482. PMID: 35792682, PMCID: PMC10029842, DOI: 10.1093/ehjci/jeac124.Peer-Reviewed Original ResearchConceptsRight ventricular systolic dysfunctionCardiac magnetic resonanceAll-Cause MortalityPredictor of all-cause mortalityRV ejection fractionPrognostic valueEjection fractionSystolic dysfunctionHeart failureQuantitative assessment of RV functionMean left ventricular ejection fractionAssessment of RV functionBaseline cardiac magnetic resonanceRV systolic dysfunctionRV systolic functionMedian Follow-UpNormal renal functionVentricular systolic dysfunctionVentricular ejection fractionReduced ejection fractionKaplan-Meier curvesRV functionNYHA III/IVSystolic functionRenal dysfunctionPrognosis of hospitalized patients with cirrhosis and acute kidney disease
Wong F, Garcia‐Tsao G, Reddy KR, O'Leary JG, Kamath PS, Tandon P, Lai JC, Vargas HE, Biggins SW, Fallon MB, Thuluvath PJ, Maliakkal BJ, Subramanian R, Thacker L, Bajaj JS. Prognosis of hospitalized patients with cirrhosis and acute kidney disease. Liver International 2022, 42: 896-904. PMID: 35023264, PMCID: PMC11075740, DOI: 10.1111/liv.15154.Peer-Reviewed Original ResearchConceptsAcute kidney diseaseStage 1 AKIAKD patientsPeak ScrAKI patientsCirrhotic patientsKidney diseaseSecond infectionEnd-stage liver diseaseDecompensated cirrhotic patientsHigher hospital admissionsWorse renal dysfunctionNormal renal functionGlomerular filtration rateNorth American ConsortiumBaseline SCrRenal dysfunctionPrompt treatmentRenal functionSerum creatinineHospital admissionClinical outcomesLiver diseasePredictive factorsFiltration rate
2020
Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease
Anantha-Narayanan M, Sheikh AB, Nagpal S, Jelani QU, Smolderen KG, Regan C, Ionescu C, Ochoa Chaar CI, Schneider M, Llanos-Chea F, Mena-Hurtado C. Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease. Journal Of Vascular Surgery 2020, 73: 331-340.e4. PMID: 32889074, DOI: 10.1016/j.jvs.2020.08.032.Peer-Reviewed Original ResearchConceptsCKD/end-stage renal diseaseEnd-stage renal diseaseNormal renal functionChronic kidney diseaseTarget lesion revascularizationLong-term mortalityPeripheral arterial diseaseRenal functionPAD interventionsMajor amputationRenal diseaseKidney diseaseOdds ratioNormal renal function groupIntervention typeRenal function groupCritical limb ischemiaPeripheral arterial interventionsConfidence intervalsPooled odds ratioOpen surgical approachMultivariable regression analysisCase-control matchingRandom-effects modelEvidence-based strategiesStent selection among patients with chronic kidney disease: Results from the NCDR CathPCI Registry
Feldman DA, Shroff AR, Bao H, Curtis JP, Minges KE, Ardati AK. Stent selection among patients with chronic kidney disease: Results from the NCDR CathPCI Registry. Catheterization And Cardiovascular Interventions 2020, 96: 1213-1221. PMID: 31909543, DOI: 10.1002/ccd.28698.Peer-Reviewed Original ResearchConceptsChronic kidney diseasePercutaneous coronary interventionST-elevation myocardial infarctionDES usageBare metal stentsNCDR CathPCI RegistryCathPCI RegistryRenal functionKidney diseasePCI casesElective percutaneous coronary interventionAdvanced renal dysfunctionNormal renal functionCoronary stent placementCKD stageRenal dysfunctionCoronary interventionUse of DESMyocardial infarctionStent placementSubgroup analysisStent usageMetal stentsPatientsStent selection
2019
Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome
Gordon C, Cleveland R, Baltrusaitis K, Massaro J, D'Agostino R, Liang M, Snyder B, Walters M, Li X, Braddock D, Kleinman M, Kieran M, Gordon L. Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome. Bone 2019, 125: 103-111. PMID: 31077852, PMCID: PMC6628204, DOI: 10.1016/j.bone.2019.05.008.Peer-Reviewed Original ResearchConceptsUrinary calcium/creatinine ratioCalcium/creatinine ratioExtraskeletal calcificationParathyroid hormoneClinical trialsHutchinson-Gilford progeria syndromeCreatinine ratioPhysical examinationNormal limitsPlasma magnesiumFibroblast growth factor 23Successive clinical trialsNormal renal functionCalcium carbonate supplementationGrowth factor 23Age-matched controlsEvaluable patientsRoutine supplementationSupplement discontinuationZoledronate therapyRenal functionCalcinosis cutisCalcium supplementationFactor 23Serum calcium
2018
Gadolinium-Based Contrast Agent-Related Toxicities
Pasquini L, Napolitano A, Visconti E, Longo D, Romano A, Tomà P, Espagnet M. Gadolinium-Based Contrast Agent-Related Toxicities. CNS Drugs 2018, 32: 229-240. PMID: 29508245, DOI: 10.1007/s40263-018-0500-1.Peer-Reviewed Original ResearchConceptsGadolinium-based contrast agentsGadolinium-based contrast agent administrationContrast agent administrationAgent administrationSystemic disease of unknown etiologyPre-contrast T1-weighted imagesDisease of unknown etiologyNormal renal functionContrast agent accumulationContrast agentsNephrogenic systemic fibrosisT1-weighted imagesSignal intensity changesRenal functionUnknown etiologyClinical consequencesKidney dysfunctionSystemic fibrosisAgent accumulationContrast agent distributionPathological samplesBrain accumulationPharmacokinetic propertiesPatientsPhysiological changesDentate nucleus T1 hyperintensity: is it always gadolinium all that glitters?
Pasquini L, Rossi Espagnet M, Napolitano A, Longo D, Bertaina A, Visconti E, Tomà P. Dentate nucleus T1 hyperintensity: is it always gadolinium all that glitters? La Radiologia Medica 2018, 123: 469-473. PMID: 29374857, DOI: 10.1007/s11547-017-0846-3.Peer-Reviewed Original ResearchConceptsGadolinium-based contrast agentsB-cell acute lymphoblastic leukemiaRadiological findingsLinear gadolinium-based contrast agentsMacrocyclic gadolinium-based contrast agentsPre-contrast T1-weighted imagesNormal renal functionAcute lymphoblastic leukemiaT1-weighted imagesAccurate clinical dataRenal functionHuman post-mortem studiesLymphoblastic leukemiaHyperintense signalB cellsDifferential diagnosisGadolinium accumulationVulnerable brain regionsClinical dataPost-mortem studiesPost-irradiation changesMultiple administrationsDentate nucleusGd depositionMagnetic resonance
2017
Statins and contrast-induced nephropathy: a systematic review and meta-analysis.
Briasoulis A, Pala M, Telila T, Merid O, Akintoye E, Vogiatzi G, Oikonomou E, Tousoulis D. Statins and contrast-induced nephropathy: a systematic review and meta-analysis. Current Pharmaceutical Design 2017, 23: 7141-7148. PMID: 28914202, DOI: 10.2174/1381612823666170913170527.Peer-Reviewed Original ResearchContrast-induced nephropathySerum creatininePrevention of CINSystematic reviewAdequate intravenous hydrationMain prevention strategyTarget vessel occlusionAcute kidney injuryHospital myocardial infarctionLow-risk patientsNormal renal functionSerum creatinine clearanceEarly adverse eventsHigh-risk populationNoninvasive coronary angiographyCIN incidenceCIN variesIntravenous hydrationKidney injuryAdverse eventsCreatinine clearanceRenal functionStatin administrationContrast loadCoronary angiographySignal intensity at unenhanced T1-weighted magnetic resonance in the globus pallidus and dentate nucleus after serial administrations of a macrocyclic gadolinium-based contrast agent in children
Rossi Espagnet M, Bernardi B, Pasquini L, Figà-Talamanca L, Tomà P, Napolitano A. Signal intensity at unenhanced T1-weighted magnetic resonance in the globus pallidus and dentate nucleus after serial administrations of a macrocyclic gadolinium-based contrast agent in children. Pediatric Radiology 2017, 47: 1345-1352. PMID: 28526896, DOI: 10.1007/s00247-017-3874-1.Peer-Reviewed Original ResearchConceptsMacrocyclic gadolinium-based contrast agentsGadolinium-based contrast agentsSignal intensity ratioGadolinium-based contrast agent administrationPediatric brainGlobus pallidus-to-thalamusUnenhanced T1-weighted MR imagesDentate nucleusUnenhanced T1-weighted magnetic resonanceAdministration of macrocyclic gadolinium-based contrast agentsEffects of multiple administrationsMR signal intensity ratioGlobus pallidusUnenhanced T1-weighted imagesSignal intensity ratio differencesNormal renal functionDentate nucleus-to-ponsT1-weighted MR imagesSignal intensityT1-weighted imagesSignal intensity changesT1-weighted magnetic resonanceContrast agentsDentate nucleus-to-pons signal intensity ratioRenal function
2016
Renal involvement in patients with mucolipidosis IIIalpha/beta: Causal relation or co‐occurrence?
Tüysüz B, Ercan-Sencicek AG, Canpolat N, Koparır A, Yılmaz S, Kılıçaslan I, Gülez B, Bilguvar K, Günel M. Renal involvement in patients with mucolipidosis IIIalpha/beta: Causal relation or co‐occurrence? American Journal Of Medical Genetics Part A 2016, 170: 1187-1195. PMID: 26749367, DOI: 10.1002/ajmg.a.37543.Peer-Reviewed Original ResearchConceptsRenal involvementFlexion contractureNormal renal functionCause of proteinuriaNephrotic range proteinuriaFocal segmental glomerulosclerosisRare lysosomal storage disorderHereditary kidney diseaseGlomerular visceral epithelial cellsNovel homozygous missense mutationVisceral epithelial cellsWhole-exome sequencingLysosomal storage disorderRenal functionBiopsy findingsRenal biopsyKidney diseaseSegmental glomerulosclerosisFamily historyChildhood onsetGNPTAB geneHealthy siblingsHomozygous missense mutationLarge jointsMild short stature
2014
Plasma Lipoprotein(a) Levels Are Associated with Mild Renal Impairment in Type 2 Diabetics Independent of Albuminuria
Lin J, Reilly MP, Terembula K, Wilson FP. Plasma Lipoprotein(a) Levels Are Associated with Mild Renal Impairment in Type 2 Diabetics Independent of Albuminuria. PLOS ONE 2014, 9: e114397. PMID: 25490096, PMCID: PMC4260843, DOI: 10.1371/journal.pone.0114397.Peer-Reviewed Original ResearchConceptsPenn Diabetes Heart StudyGFR impairmentT2DM patientsRisk factorsModifiable CV risk factorsSingle-center observational cohortAtherogenic lipid profileCV risk factorsMild renal impairmentIndependent risk factorNormal renal functionWorse kidney functionType 2 diabeticsCKD-EPI equationDiabetes Heart StudyCross-sectional analysisLogistic regression modelsClinical CVDMild CKDCV diseaseRenal impairmentObservational cohortRenal functionCV preventionDiabetic counterpartsHospitalized Hemorrhagic Stroke Patients with Renal Insufficiency: Clinical Characteristics, Care Patterns, and Outcomes
Ovbiagele B, Schwamm L, Smith E, Grau-Sepulveda M, Saver J, Bhatt D, Hernandez A, Peterson E, Fonarow G. Hospitalized Hemorrhagic Stroke Patients with Renal Insufficiency: Clinical Characteristics, Care Patterns, and Outcomes. Journal Of Stroke And Cerebrovascular Diseases 2014, 23: 2265-2273. PMID: 25158677, DOI: 10.1016/j.jstrokecerebrovasdis.2014.04.016.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseNormal renal functionICH patientsClinical characteristicsRenal functionKidney diseaseCare patternsDeep venous thrombosis prophylaxisGuidelines-Stroke programGWTG-Stroke programVenous thrombosis prophylaxisThird of patientsGlomerular filtration rateHemorrhagic stroke patientsNormal kidney functionIntracerebral hemorrhage patientsSmoking cessation interventionHospital mortalityThrombosis prophylaxisHospital outcomesRenal dysfunctionRenal insufficiencyInpatient mortalityClinical outcomesComorbid conditions
2013
Clinicopathologic Changes in Children with Immunoglobulin A Nephritis and Henoch-Schönlein Purpura Nephritis after Cyclosporine A and Angiotensin-converting Enzyme Inhibitor Treatment
Lee J, Kim Y, Shin J, Yim H, Park J. Clinicopathologic Changes in Children with Immunoglobulin A Nephritis and Henoch-Schönlein Purpura Nephritis after Cyclosporine A and Angiotensin-converting Enzyme Inhibitor Treatment. Childhood Kidney Diseases 2013, 17: 92-100. DOI: 10.3339/jkspn.2013.17.2.92.Peer-Reviewed Original ResearchHenoch-Schonlein purpura nephritisClass II diseaseCsA treatmentII diseaseTubular atrophyPurpura nephritisHSPN groupMesangial immunoglobulin A depositsCyclosporin AProgression to end-stage renal failureAngiotensin-converting enzyme inhibitor treatmentMaintained normal renal functionEnd-stage renal failureCortical tubular atrophyTreated with CsA.Effect of cyclosporin AFollow-up biopsiesNormal renal functionRemission of proteinuriaDose of CsACortical interstitial fibrosisNo significant complicationsDegree of proteinuriaImmunoglobulin A depositionImmunoglobulin A nephritis
2012
Quality of Care and Outcomes Among Patients With Acute Myocardial Infarction by Level of Kidney Function at Admission: Report From the Get With The Guidelines Coronary Artery Disease Program
Vasaiwala S, Cannon C, Fonarow G, Peacock W, Laskey W, Schwamm L, Liang L, Hernandez A, Peterson E, Rosas S, Bhatt D, Committee and Investigators G. Quality of Care and Outcomes Among Patients With Acute Myocardial Infarction by Level of Kidney Function at Admission: Report From the Get With The Guidelines Coronary Artery Disease Program. Clinical Cardiology 2012, 35: 541-547. PMID: 22744797, PMCID: PMC6652568, DOI: 10.1002/clc.22021.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionGuidelines-Coronary Artery Disease programChronic renal insufficiencyRenal insufficiencyGlomerular filtration rateRenal functionInpatient careAMI patientsKidney failureMyocardial infarctionDisease programsAMI performance measuresGuideline-recommended therapiesMild renal insufficiencyModerate renal insufficiencySevere renal dysfunctionNormal renal functionSevere renal insufficiencyAmerican Heart AssociationMultivariable regression analysisQuality of careHospital mortalityRenal dysfunctionPatient characteristicsAdjusted mortality
2011
Phase I study of the effects of renal impairment on the pharmacokinetics and safety of satraplatin in patients with refractory solid tumors
Galsky M, Camacho L, Chiorean E, Mulkerin D, Hong D, Oh W, Bajorin D. Phase I study of the effects of renal impairment on the pharmacokinetics and safety of satraplatin in patients with refractory solid tumors. Annals Of Oncology 2011, 23: 1037-1044. PMID: 21828377, DOI: 10.1093/annonc/mdr358.Peer-Reviewed Original ResearchConceptsRenal impairmentRenal functionSolid tumorsModerate to severe renal impairmentDay 1Dose-limiting toxic effectsEffect of renal impairmentDegree of renal impairmentRefractory to standard therapyLevel of renal functionRenal function groupMild renal impairmentRefractory solid tumorsSevere renal impairmentNormal renal functionPhase I studyCohort of patientsDose deescalationPlasma platinumStandard therapyToxic effectsUltrafiltrable platinumAdverse eventsPlatinum analogsGroup 1Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study
Leal T, Remick S, Takimoto C, Ramanathan R, Davies A, Egorin M, Hamilton A, LoRusso P, Shibata S, Lenz H, Mier J, Sarantopoulos J, Mani S, Wright J, Ivy S, Neuwirth R, von Moltke L, Venkatakrishnan K, Mulkerin D. Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study. Cancer Chemotherapy And Pharmacology 2011, 68: 1439-1447. PMID: 21479634, PMCID: PMC3481841, DOI: 10.1007/s00280-011-1637-5.Peer-Reviewed Original ResearchConceptsSevere renal dysfunctionNormal renal functionRenal dysfunctionAdult cancer patientsRenal functionDialysis patientsDose escalationCancer patientsPatient populationNational Cancer Institute Organ Dysfunction Working Group StudyDose of bortezomibImpaired renal functionGeneral patient populationIntravenous bortezomibRenal impairmentCreatinine clearanceModerate dysfunctionMild dysfunctionSevere dysfunctionDose reductionPharmacologic dataPatientsDay 1DysfunctionBortezomibRole of renalase in the regulation of blood pressure and the renal dopamine system
Desir GV. Role of renalase in the regulation of blood pressure and the renal dopamine system. Current Opinion In Nephrology & Hypertension 2011, 20: 31-36. PMID: 21099685, DOI: 10.1097/mnh.0b013e3283412721.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseDahl salt-sensitive ratsRenal dopamine systemSalt-sensitive ratsRenalase deficiencyBlood pressureKidney diseaseRenalase levelsResistant hypertensionRecombinant renalaseDopamine systemProximal tubular sodium transportStable coronary artery diseaseComparable blood pressurePlasma renalase levelsRole of renalaseMechanisms of hypertensionNormal renal functionTubular sodium transportCoronary artery diseaseElevation of plasmaPotent antihypertensive agentSevere cardiac hypertrophyKnockout mouse modelRenalase expression
2010
Renal Dysfunction Is the Most Important Independent Predictor of Mortality in Cirrhotic Patients With Spontaneous Bacterial Peritonitis
Tandon P, Garcia–Tsao G. Renal Dysfunction Is the Most Important Independent Predictor of Mortality in Cirrhotic Patients With Spontaneous Bacterial Peritonitis. Clinical Gastroenterology And Hepatology 2010, 9: 260-265. PMID: 21145427, PMCID: PMC3713475, DOI: 10.1016/j.cgh.2010.11.038.Peer-Reviewed Original ResearchConceptsRenal dysfunctionCirrhotic patientsBacterial peritonitisAscitic fluid cell countHigh-risk patientsMain prognostic factorsNormal renal functionSpontaneous bacterial peritonitisHigh-risk groupImportant independent predictorBlood urea nitrogenGood quality studiesSBP resolutionVasoconstrictor therapyMELD scoreAdult patientsRenal functionIndependent predictorsMedian agePrognostic factorsRisk stratificationCommon infectionsImmunosuppressive factorsPrognostic valuePrognostic studiesSuccessful Transplantation of a Split Crossed Fused Ectopic Kidney into a Patient with End‐Stage Renal Disease
Mekeel KL, Daley SM, Andrews PE, Moss AA, Heilman RL, Mazur MJ, Chakkera HA, Hamawi K, Mulligan DC, Reddy K. Successful Transplantation of a Split Crossed Fused Ectopic Kidney into a Patient with End‐Stage Renal Disease. Journal Of Transplantation 2010, 2010: 383972. PMID: 20368777, PMCID: PMC2846343, DOI: 10.1155/2010/383972.Peer-Reviewed Original ResearchFused ectopic kidneyEctopic kidneySimultaneous kidney-pancreas transplantDeceased donor kidney transplantEnd-stage renal diseaseCongenital renal anomaliesKidney-pancreas transplantNormal renal functionDonor kidney transplantsPancreas transplantsKidney transplantRenal functionRenal diseaseParenchymal transectionRenal anomaliesSuccessful transplantationImmediate functionWaiting listTransplantPotential transplantsExcellent functionKidneyPotential donorsPatientsTransplantation
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